A novel amperometric biosensor based on ZnO:Co nanoclusters for biosensing glucose

Zhao, Zhigang; Chen, X.J.; Tay, Beng Kang; Chen, J.S.; Han, Zhaojun; Khor, K.A.

doi:10.1016/j.bios.2007.03.014

Cited by 166 publications

(65 citation statements)

References 24 publications

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“…Thereby, ZnO nanoparticles can help to accommodate GOD through strong electrostatic forces and a good shelf life. In addition, ZnO possess good electrical conductivity, which enhances the direct electron transfer between the active site of GOD to the sensitive layer suitable for electrochemical sensing [15,16]. In this context, the use of core-shell nanocomposites to fabricate biosensors is one of the current moving approaches because metal oxide viz.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a tunable glucose biosensor based on zinc oxide/chitosan-graft-poly(vinyl alcohol) core-shell nanocomposite

Shukla

Deshpande

Shukla

et al. 2012

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A potentiometrically tuned-glucose biosensor was fabricated using core-shell nanocomposite based on zinc oxide encapsulated chitosan-graft-poly(vinyl alcohol) (ZnO/CHIT-g-PVAL). The glucose oxidase (GOD) was immobilized onto ZnO/CHIT-g-PVAL coated indium-tin oxide (ITO) glass substrate. The electrostatic interaction between GOD and ZnO based core-shell nanocomposite provided the resulting tuned enzyme electrode (GOD/ZnO/CHIT-g-PVAL) with a high level of enzyme immobilization and excellent lifetime stability. The response studies were carried out as a function of GOD concentration with potentiometric measurement. The GOD/ZnO/CHIT-g-PVAL/ITO bioelectrode has showed a linear potential response to the glucose concentration ranging from 2 μM to 1.2 mM. The glucose biosensor exhibited a sensitivity of >0.04 V/M with a response time within three sec.

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Section: Introductionmentioning

confidence: 99%

Fabrication of a tunable glucose biosensor based on zinc oxide/chitosan-graft-poly(vinyl alcohol) core-shell nanocomposite

Shukla

Deshpande

Shukla

et al. 2012

Talanta

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“…Porous ZnO: Co nanoclusters with an average particle size of 5 nm were synthesized by nanocluster-beam deposition. They were incorporated into a glucose sensor via Nafion-assisted cross-linking [63]. The ZnO: Co nanostructure had a high number of active sites, and high electrocatalytic activity.…”

Section: Science China Materialsmentioning

confidence: 99%

ZnO nanostructures in enzyme biosensors

et al. 2015

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Biosensing has developed tremendously since it was demonstrated by Leland C. Clark Jr. in 1962. ZnO nanomaterials are attractive candidates for fabricating biosensors, because of their diverse range of nanostructures, high electron mobility, chemical stability, electrochemical activity, high isoelectric points which promote enzyme adsorption, biocompatibility, and piezoelectric properties. This review covers ZnO nanostructures applied in enzyme biosensors, in the light of electrochemical transduction and field effect transduction. Different assembly processes and immobilization methods have been used to load enzymes into various ZnO nanostructures, providing enzymes with favorable micro-environments and enhancing their sensing performance. We briefly describe recent trends in ZnO syntheses, and the analytical performance of the fabricated biosensors, summarize the advantages of using ZnO nanostructures in biosensors, and conclude with future challenges and prospects.

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“…Moreover, this glucose sensor showed long term stability with the incorporation of the inorganic zinc oxide nanowire. Zhao et al, (2007) proposed new strategy for co-adsoprtion of GOx onto porous Co doped ZnO nanoclusters with an averaged particle size of 5 nm to construct a novel amperometric glucose sensing. Electrochemical characterization of the developed ZnO-based nanoclusters electrode shows nanoporous network structure, making them differ from undoped ZnO nanostructures and other low dimensional nanostructures.…”

Section: Glucose Biosensorsmentioning

confidence: 99%