A novel alkaline phosphatase activity sensing strategy combining enhanced peroxidase-mimetic feature of sulfuration-engineered CoOx with electrostatic aggregation

Song, Hongwei; Niu, Xiangheng; Ye, Kun; Wang, Linjie; Xu, Yuhu; Peng, Yinxian

doi:10.1007/s00216-020-02815-1

Cited by 10 publications

(1 citation statement)

References 66 publications

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“…To detect phosphatases, Peng et al proposed a novel sensing method for alkaline phosphatase (ALP) activity based on the modified POD-mimetic catalysis of sulfideengineered CoOx and hexametaphosphate ion (HMPi)-mediated electrostatic aggregation. [137] The CoOx composite oxidizes TMB to oxTMB. Moreover, the negatively charged HMPi undergoes rapid electrostatic assembly with the positively charged oxTMB, resulting in the latter aggregating and producing discoloration.…”

Section: Enzymesmentioning

confidence: 99%

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Li,

Cai,

Jiang

et al. 2023

Advanced Materials

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Nanozymes, next‐generation enzyme‐mimicking nanomaterials, have entered an era of rational design; among them, Co‐based nanozymes have emerged as captivating players over times. Co‐based nanozymes were developed and have garnered significant attention over the past five years. Their extraordinary properties, including regulatable enzymatic activity, stability, and multifunctionality stemming from magnetic properties, photothermal conversion effects, cavitation effects, and relaxation efficiency, have made Co‐based nanozymes a rising star. This review presents the first comprehensive profiling of the Co‐based nanozymes in the chemistry, biology, and environmental sciences. The review begins by scrutinizing the various synthetic methods employed for Co‐based nanozyme fabrication, such as template and sol‐gel methods, highlighting their distinctive merits from a chemical standpoint. Furthermore, we provide a detailed exploration of their wide‐ranging applications in biosensing and biomedical therapeutics, as well as their contributions to environmental monitoring and remediation. Notably, drawing inspiration from state‐of‐the‐art techniques such as omics, a comprehensive analysis of Co‐based nanozymes is undertaken, employing analogous statistical methodologies to provide valuable guidance. To conclude, we present a comprehensive outlook on the challenges and prospects for Co‐based nanozymes, spanning from microscopic physicochemical mechanisms to macroscopic clinical translational applications.This article is protected by copyright. All rights reserved

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Section: Enzymesmentioning

confidence: 99%

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Li,

Cai,

Jiang

et al. 2023

Advanced Materials

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Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Tian,

Li,

Tang

et al. 2024

Adv Healthcare Materials

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As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared to protein‐based enzymes, nanozymes exhibit attractive characteristics of low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them with wide use from biochemical sensing and environmental remediation to medical theranostics. Especially in biomedical diagnosis, the feature of catalytic signal amplification provided by nanozymes makes them function as emerging labels for the detection of biomarkers and diseases, with rapid developments observed in recent years. To provide a comprehensive overview of recent progress made in this dynamic field, here an overview of biomedical diagnosis enabled by nanozymes is provided. This review first summarizes the synthesis of nanozyme materials and then discusses the main strategies applied to enhance their catalytic activity and specificity. Subsequently, representative utilization of nanozymes combined with biological elements in disease diagnosis is reviewed, including the detection of biomarkers related to metabolic, cardiovascular, nervous, and digestive diseases as well as cancers. Finally, some development trends in nanozyme‐enabled biomedical diagnosis are highlighted, and corresponding challenges are also pointed out, aiming to inspire future efforts to further advance this promising field.

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Electrochemical detection of alkaline phosphatase activity through enzyme-catalyzed reaction using aminoferrocene as an electroactive probe

et al. 2021

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A novel alkaline phosphatase activity sensing strategy combining enhanced peroxidase-mimetic feature of sulfuration-engineered CoOx with electrostatic aggregation

Cited by 10 publications

References 66 publications

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Electrochemical detection of alkaline phosphatase activity through enzyme-catalyzed reaction using aminoferrocene as an electroactive probe

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