A novel alginate/gelatin sponge combined with curcumin-loaded electrospun fibers for postoperative rapid hemostasis and prevention of tumor recurrence

Chen, Kai; Pan, Hao; Yan, Zhifang; Li, Yunjian; Ji, Dongxu; Yun, Kaiqing; Su, Yupei; Liu, Dandan; Pan, Weisan

doi:10.1016/j.ijbiomac.2021.05.074

Cited by 45 publications

(28 citation statements)

References 53 publications

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“…The characteristic peaks of these two materials are apparent and consistent with the results of other related studies. [ 44 ] The characteristic peaks of SP appeared at 3396, 2929, 1641, 1546, 1401, 1052, and 671 cm −1 . The band at 3396 cm −1 referred to the stretching vibration of the amide A.…”

Section: Resultsmentioning

confidence: 99%

Alginate/Gelatin‐Based Hydrogel with Soy Protein/Peptide Powder for 3D Printing Tissue‐Engineering Scaffolds to Promote Angiogenesis

Liu

Dong

et al. 2022

Macromolecular Bioscience

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In recent years, 3D bioprinting has attracted broad research interest in biomedical engineering and clinical applications. However, there are two issues need to be solved urgently at present, the development of ink is the first pressing thing for 3D printing tissue engineering scaffold, other thing is the promotion of angiogenesis in the scaffold. Therefore, a gelatin/sodium alginate‐based hydrogel with protein‐rich is developed here, which is prepared by gelatin, sodium alginate, and soy protein/soy peptide powder. The prepared inks exhibit excellent shear‐thinning behavior, which contribute to extrusion‐based printing; also shown good crosslinking ability by calcium chloride. The macroporous composite scaffolds are printed by 3D printing using the developed ink and the physicochemical properties of the scaffolds are evaluated. Moreover, the cytocompatibility of printed scaffold is characterized by using human umbilical vein epidermal cells, results show that the scaffolds with soy protein and soy peptide powder can promote cell attach, spread, migration, and proliferation. The further research of chicken embryo allantoic membrane assay and animal experiment are carried, and results present that the scaffold can promote the growth of neo‐vessels in the scaffold, which means the developed ink with soy protein and soy peptide powder has great potential for angiogenesis.

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Section: Resultsmentioning

confidence: 99%

Alginate/Gelatin‐Based Hydrogel with Soy Protein/Peptide Powder for 3D Printing Tissue‐Engineering Scaffolds to Promote Angiogenesis

Liu

Dong

et al. 2022

Macromolecular Bioscience

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“…Generally, the material with the stronger physical absorption capacity has the better hemostatic effect, such as highabsorbency gelatin sponge. 44 Therefore, the water/blood performance has become one of the factors in the study of hemostatic mechanism of hemostatic materials. 45 Water absorption is an essential physical property of fast hemostatic materials.…”

Section: Resultsmentioning

confidence: 99%

“…In this way, the hemostatic material achieves rapid hemostasis. Generally, the material with the stronger physical absorption capacity has the better hemostatic effect, such as high-absorbency gelatin sponge . Therefore, the water/blood performance has become one of the factors in the study of hemostatic mechanism of hemostatic materials .…”

Section: Resultsmentioning

confidence: 99%

Highly Absorbent Silk Fibroin Protein Xerogel

Cheng

Tao

et al. 2021

ACS Biomater. Sci. Eng.

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Highly absorbent polymers have a wide range of applications in biomaterials, agriculture, physiological products of daily uses, and others. Silk fibroin, as a natural biomaterial with excellent biocompatibility and tunable mechanical properties, shows good prospects in the field of biomedicine applications. However, the dried fibroin hydrogel has very low absorbency. In this work, silk fibroin protein is used as the carrier, riboflavin as the photosensitizer, and accordingly, the hydrogel is prepared by free radical cross-linking under ultraviolet light. The fibroin in the hydrogel contains mainly the random coil structure. The covalent bond cross-linking hinders the crystallization of the silk fibroin, thereby an amorphous silk fibroin hydrogel is obtained. After drying, this xerogel can absorb water 90 times more than its own mass and assimilates a good amount of water within a minute. In vitro and in vivo rabbit ear hemostasis experiments show that this fabricated xerogel has good hemostatic properties. Therefore, this xerogel exhibits good promise for rapid hemostasis of wounds and absorbing other body exudates.

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“…The hemostatic effectuality of gelatin is complemented when combined with other suitable hemostatic materials, such as alginate, collagen, graphene oxide, transglutaminase, and many more. Chen et al, have synthesized an alginate/gelatin sponge integrated with curcumin-loaded electrospun fibers (CFAGS) in an attempt to prevent post-operative bleeding and tumor recurrence [57]. The alginate/gelatin sponge was seen to control the release of curcumin, which accumulates at the surgical site and inhibits the local tumor recurrence.…”

Section: Collagen/gelatinmentioning

confidence: 99%

“…The sponge showed better results compared to the commercially available gelatin-based hemostasis sponges. Furthermore, it was devised to be non-toxic and did not trigger any harmful reactions in the body's tissues and internal organs [57]. By the same token, Chu et al, have developed a microbial transglutaminase crosslinked thrombinloaded gelatin hydrogel, which acted as a hemostatic sealant in liver trauma inflicted on rat models [58].…”

Section: Collagen/gelatinmentioning

confidence: 99%

Polymeric Materials for Hemostatic Wound Healing

et al. 2021

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Hemorrhage is one of the greatest threats to life on the battlefield, accounting for 50% of total deaths. Nearly 86% of combat deaths occur within the first 30 min after wounding. While external wound injuries can be treated mostly using visual inspection, abdominal or internal hemorrhages are more challenging to treat with regular hemostatic dressings because of deep wounds and points of injury that cannot be located properly. The need to treat trauma wounds from limbs, abdomen, liver, stomach, colon, spleen, arterial, venous, and/or parenchymal hemorrhage accompanied by severe bleeding requires an immediate solution that the first responders can apply to reduce rapid exsanguinations from external wounds, including in military operations. This necessitates the development of a unique, easy-to-use, FDA-approved hemostatic treatment that can deliver the agent in less than 30 s and stop bleeding within the first 1 to 2 min at the point of injury without application of manual pressure on the wounded area.

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A novel alginate/gelatin sponge combined with curcumin-loaded electrospun fibers for postoperative rapid hemostasis and prevention of tumor recurrence

Cited by 45 publications

References 53 publications

Alginate/Gelatin‐Based Hydrogel with Soy Protein/Peptide Powder for 3D Printing Tissue‐Engineering Scaffolds to Promote Angiogenesis

Alginate/Gelatin‐Based Hydrogel with Soy Protein/Peptide Powder for 3D Printing Tissue‐Engineering Scaffolds to Promote Angiogenesis

Highly Absorbent Silk Fibroin Protein Xerogel

Polymeric Materials for Hemostatic Wound Healing

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