A novel alginate from Sargassum seaweed promotes diabetic wound healing by regulating oxidative stress and angiogenesis

Lu, Xuxiu; Qin, Ling; Guo, Meng; Geng, Jiajia; Dong, Songtao; Wang, Kai; Hong, Xu; Qu, Changfeng; Miao, Jun; Liu, Ming

doi:10.1016/j.carbpol.2022.119437

Cited by 24 publications

(8 citation statements)

References 52 publications

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“…Regarding to NPs having regulation on Nrf2 antioxidant pathway from algae, structural features of them from Laminaria japonica ( 97 , 98 ), Enteromorpha prolifera ( 24 , 31 ), Sargassum fusiforme ( 99 ), Sargassum kjellmanianum ( 17 ), and Hizikia fusiforme ( 44 ) have been characterized. Their M w values ranged from 4.929 to 250 kDa ( 24 , 97 ).…”

Section: Structural Features Of Nps Having Regulation On Nrf2 Antioxi...mentioning

confidence: 99%

“…Their M w values ranged from 4.929 to 250 kDa ( 24 , 97 ). They were made up of Fuc, Man, Rha, Ara, Gal, Glc, Xyl, GlcA, GalA, ManA, and guluronic acid (GulA) ( 17 , 44 , 99 ). Comparatively, Fuc and Rha were two monosaccharide types widely detected in the polysaccharides ( 31 , 44 , 97 , 99 ).…”

Section: Structural Features Of Nps Having Regulation On Nrf2 Antioxi...mentioning

confidence: 99%

“…Polysaccharides from natural resources (NPs) have been reported to play key roles in regulating excessive oxidative stress ( 13 ). In the past few decades, regulations of NPs on Nrf2 antioxidant pathway have been extensively studied in their health-promoting effects, such as liver protection ( 14 ), antioxidant ( 15 ), gastrointestinal protection ( 16 ), anti-diabetic ( 17 ), anti-aging ( 18 ), cardioprotection ( 19 ), lung protection ( 20 ), kidney protection ( 21 ), neuroprotection ( 22 ), anti-inflammation ( 23 ), immunomodulation ( 24 ), anti-depression ( 25 ), anti-cancer ( 26 ), improving reproductive function ( 27 ), anti-radiation ( 28 ), and anti-atherosclerosis ( 29 ). However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes.…”

Section: Introductionmentioning

confidence: 99%

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Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Luo

Shen

et al. 2023

Front. Nutr.

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Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important endogenous antioxidant pathway, which plays crucial roles in maintaining human health as its protection against oxidative stress. Accumulating evidence suggested that Nrf2 antioxidant pathway might be one of key regulatory targets for the health-promoting effects of NPs. However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes. Therefore, in this article, structural features of NPs having regulation on Nrf2 antioxidant pathway are overviewed. Moreover, regulatory effects of NPs on this pathway for health-promoting effects are summarized. Furthermore, structure-activity relationship of NPs for health-promoting effects by regulating the pathway is preliminarily discussed. Otherwise, the prospects on future work for regulation of NPs on this pathway are proposed. This review is beneficial to well-understanding of underlying mechanisms for health-promoting effects of NPs from the view angle of Nrf2 antioxidant pathway, and provides a theoretical basis for the development and utilization of NPs in promoting human health.

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Section: Structural Features Of Nps Having Regulation On Nrf2 Antioxi...mentioning

confidence: 99%

Section: Structural Features Of Nps Having Regulation On Nrf2 Antioxi...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Luo

Shen

et al. 2023

Front. Nutr.

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“…Natural products have gained huge popularity as a source of new bioactive ingredients for drug development, leading to rapid growth in biomedical research. As natural biomaterials, collagen [ 84 , 85 ], gelatin [ 86 ], chitosan [ 87 ], hyaluronic acid [ 88 , 89 ], and alginates [ 90 ] have shown promising results for skin wound healing. Recently, Gaspar-Pintiliescu et al presented the main characteristics and properties of natural biomaterials, the advantages and disadvantages of commercial wound dressings, and the mechanisms involved in wound healing [ 91 ].…”

Section: Natural-based Products For Wound Healingmentioning

confidence: 99%

The Discovery and Development of Natural-Based Biomaterials with Demonstrated Wound Healing Properties: A Reliable Approach in Clinical Trials

et al. 2022

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Current research across the globe still focuses strongly on naturally derived biomaterials in various fields, particularly wound care. There is a need for more effective therapies that will address the physiological deficiencies underlying chronic wound treatment. The use of moist bioactive scaffolds has significantly increased healing rates compared to local and traditional treatments. However, failure to heal or prolonging the wound healing process results in increased financial and social stress imposed on health institutions, caregivers, patients, and their families. The urgent need to identify practical, safe, and cost-effective wound healing scaffolding from nature-based biomaterials that can be introduced into clinical practice is unequivocal. Naturally derived products have long been used in wound healing; however, clinical trial evaluations of these therapies are still in their infancy. Additionally, further well-designed clinical trials are necessary to confirm the efficacy and safety of nature-based biomaterials in treating wounds. Thus, the focus of this review is to describe the current insight, the latest discoveries in selected nature-based wound healing implant products, the possible action mechanisms, and an approach to clinical studies. We explore several tested products undergoing clinical trials as a novel approach to counteract the debilitating effects of impaired wound healing.

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“…The abundance of stabilization elements such as carotenoids in marine resources [ 29 ], bioactive compounds such as catechins [ 41 ], and seaweed phenolic antioxidants [ 42 ] are significant indications for potential uses of seaweed in anti-ageing products. Brown seaweeds are sources of alginate-based compositions available for protective applications [ 43 , 44 , 45 ]. The variety of preparation procedures starting from macroalgae [ 46 , 47 , 48 , 49 ] is an open door for the usage of alginates as efficient protectors against oxidation in polymer composites [ 28 , 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

Stabilization Activity of Kelp Extract in Ethylene–Propylene Rubber as Safe Packaging Material

Zaharescu¹

2023

Polymers

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This paper presents the stabilization effects of the solid extract of kelp (Ascophyllum nodosum) on an engineering elastomer, ethylene–propylene copolymer (EPR), which may be used as packaging material. Progressive increase in additive loadings (0.5, 1, and 2 phr) increases the oxidation induction time for thermally aged rubber at 190 °C from 10 min to 30 min for pristine material and modified polymer by adding 2 phr protection powder. When the studied polymer is γ-irradiated at 50 and 100 kGy, the onset oxidation temperatures increase as a result of blocking the oxidation reactivity of free radicals. The stabilization effect occurs through the activity of alginic acid, which is one of the main active components associated with alginates. The accelerated degradation caused by γ-exposure advances more slowly when the kelp extract is present. The OOT value for the oxidation of EPR samples increases from 130 °C to 165 °C after the γ-irradiation of pristine and modified (2 phr of kelp powder) EPR, respectively. The altered oxidation state of EPR samples by the action of γ-rays in saline serum is faster in neat polymer than in stabilized material. When the probes are placed in physiological serum and irradiated at 25 kGy, the OOT value for neat EPR (145 °C) is much lower than the homologous value for the polymer samples protected by kelp extract (153 °C for the concentration of 0.5 phr, 166 °C for the concentration of 1 phr, and 185 °C for the concentration of 2 phr).

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A novel alginate from Sargassum seaweed promotes diabetic wound healing by regulating oxidative stress and angiogenesis

Cited by 24 publications

References 52 publications

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

The Discovery and Development of Natural-Based Biomaterials with Demonstrated Wound Healing Properties: A Reliable Approach in Clinical Trials

Stabilization Activity of Kelp Extract in Ethylene–Propylene Rubber as Safe Packaging Material

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