A novel 18β-glycyrrhetinic acid derivative supramolecular self-assembly hydrogel with antibacterial activity

Abstract

Hydrogels are kinds of soft materials with 3D network structure, which play important roles in medical materials, such as contact lenses, surgical implants, wound dressings, artificial skin, drug release carriers, suture coatings, especially antibacterial materials that could solve problems of microbial infections. There are many studies on 18b-glycyrrhetinic acid (GA) derivatives hydrogel, but few on application in antibacterial materials. GA-O-20, one of GA derivatives, showed marvelous antibacterial property compared with its parent compound GA. Therefore, it was adopted as basic functional material to prepare supramolecular self-assembly hydrogels in the mixture solvent of water and ethanol. This hydrogel exhibits outstanding thermodynamic stability; the gel melting temperature (T gel ) is high to 96.6 ± 0.48 °C. Besides, it presented exceptional antibacterial that its minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) value are 6.25 and 12.5 lM, respectively, which was possibility caused by its sustained self-released property. This supramolecular self-assembly hydrogel may have enormous potentials in the application of antibacterial materials and drug delivery, which can be helpful to expand the application of GA derivatives.

Injectable Carrier-Free Hydrogel Dressing with Anti-Multidrug-Resistant Staphylococcus aureus and Anti-Inflammatory Capabilities for Accelerated Wound Healing

“…48,49 Furthermore, due to its unique threedimensional structure, multifunctional groups, multichiral centers, good biocompatibility, and biological activity, it is generally used as a building block for the construction of supramolecular hydrogel systems. 50 However, the antibacterial hydrogels designed with glycyrrhetinic acid derivatives are rarely applicated. Therefore, using GA as the mother nucleus to construct supramolecular antibacterial materials with both self-assembly and antibacterial properties has higher development and utilization value.…”

“…They have been extensively studied as antibacterial agents due to their broad-spectrum antibacterial activity and unique antibacterial mechanism. − Glycyrrhetinic acid (GA) is a typical representative of pentacyclic triterpenes, since it has various physiological activities such as anticancer, antivirus, antibacterial, and anti-inflammatory . Among them, its anti-MRSA and anti-inflammatory effects have attracted increasing attention over time, which is expected to become a new research field. , Furthermore, due to its unique three-dimensional structure, multifunctional groups, multichiral centers, good biocompatibility, and biological activity, it is generally used as a building block for the construction of supramolecular hydrogel systems . However, the antibacterial hydrogels designed with glycyrrhetinic acid derivatives are rarely applicated.…”

Self-assembled glycyrrhetinic acid derivatives for functional applications: a review

“…Numerous studies have attempted to understand that GA and its derivatives have the tendency to self-assemble into different macrostructures, such as gels, 32,35,36 micelles, 31,37 liposomes, 38,39 nanoparticles, [40][41][42] and so on. At the same time, compounds with varied structural differences demonstrate their skills in a variety of domains.…”

“…Looking back on GA articles over the past few years, several review articles have summarized and related to some of the treatment of liver cancer aspects of self-assembled targeting nanosystems, 4,48,49 the pharmacological activity of GA, 32,50 and GL nanofibril applications in multiphase food systems. 51 There is still a gap with regard to self-assembled GA derivatives for describing their applications comprehensively, including for drug delivery systems, 52 stimulus-responsive polymers, 35,47,[53][54][55] liquid propellants, 56 catalytic carrier materials, 27,44 flexible sensors, 57 and food-grade foams.…”

Novel Natural Glycyrrhetinic Acid-Derived Super Metal Gel and Its Highly Selective Dyes Removal

“…Taking full advantage of natural products in biomedical applications is a current hot topic [ 5 , 6 ]. It has been reported that glycyrrhetinic acid derivatives could be used as basis functional materials for supramolecular hydrogels and that they exhibited excellent bioactivity [ 7 ]. In our former work, we found that one of the natural glycyrrhetinic acid derivatives, GA-O-09, could form hydrogels and exhibit excellent antibacterial activity [ 8 , 9 ].…”