Self-assembled glycyrrhetinic acid derivatives for functional applications: a review

Abstract

Glycyrrhetinic acid (GA), a famous natural product, has attracted much more attention because of its remarkable biological activity, natural sweetness, and good biocompatibility. In the past few years, a considerable...

A review of typical biological activities of glycyrrhetinic acid and its derivatives

“…Moreover, 18β-GA derivatives that self-assemble, including gels, micelles, nanoparticles, and liposomes, hold potential for application in food additives and intelligent drug delivery due to availability, biocompatibility, and controllable degradability. 154 Additionally, while the mainstream research direction focuses on the aforementioned topics, shifting the focus to other biologically active research areas such as anti-diabetes, anti-coagulation, and neuroprotection, could prove worthwhile, as the studies in these areas are still relatively scarce. This could further broaden the development prospects of 18β-GA derivatives and increase their role in various fields.…”

Glycyrrhizic acid aggregates seen from a synthetic surfactant perspective

“…Intelligent biomaterials, structural framework using the chiral skeleton, (soft-liquid, rigid structure), drug delivery system. 12 Good use to replace the synthetic low molecular weight hydrogelators. 8 Due to the pH dependence, the pH solution should be monitored when GA is used as an This journal is © the Societies 2024 emulsifier or solubilizer in practical fields.…”

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

“…Glycyrrhetinic acid, also known as 18‐β‐glycyrrhetinic acid, is the primary active compound derived from the medicinal herb Glycyrrhizae 198 . This compound exhibits a broad spectrum of anticancer activities in various experimental systems, including hepatocellular carcinoma, gastric cancer, breast cancer, lung cancer, leukaemia and thyroid cancer 199–203 . The cytotoxic and anti‐tumour properties of glycyrrhetinic acid can be attributed to the triterpene functional groups (COOH and OH) present in its molecular structure 204 …”

“…198 This compound exhibits a broad spectrum of anticancer activities in various experimental systems, including hepatocellular carcinoma, gastric cancer, breast cancer, lung cancer, leukaemia and thyroid cancer. [199][200][201][202][203] The cytotoxic and anti-tumour properties of glycyrrhetinic acid can be attributed to the triterpene functional groups (COOH and OH) present in its molecular structure. 204 Glycyrrhetinic acid shows promise as a drug delivery vehicle for hepatocellular carcinoma treatment by utilizing receptor-mediated endocytosis, effectively addressing its low lipophilicity and poor bioavailability.…”