A Note on the Rapid Assay of 17-Ketogenic Steroids in Urine

Gibson, Glenn; Norymberski, J. K.

doi:10.1136/ard.13.1.59

Cited by 46 publications

(8 citation statements)

References 2 publications

(1 reference statement)

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“…Serum-vitamin-B12 estimations were performed by microbiological assay using Euglena gracilis Z strain as the test organism (Ross et al, 1957). Urinary 17-ketogenic-steroids were estimated by the method of Gibson and Norymberski (1954). A 24-hour collection of urine was made from 8 a.m. on the first day to 8 a.m. on the second day.…”

Section: Methodsmentioning

confidence: 99%

Hyperpigmentation of Skin

Baker¹,

Ignatius²,

Johnson³

et al. 1963

BMJ

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Section: Methodsmentioning

confidence: 99%

Hyperpigmentation of Skin

Baker¹,

Ignatius²,

Johnson³

et al. 1963

BMJ

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“…In addition, a number of routine urinary hormone assays were carried out on these patients as further aids to the diagnosis of the syndrome. 17-Ketosteroids were determined by the method of Gibson and Norymberski (1954), and 17-ketogenic steroids by minor modifications of the method of Norymberski et al (1953).…”

mentioning

confidence: 99%

Defective Biosynthesis of Ovarian Steroids in the Stein-Leventhal Syndrome

Short¹,

London²

1961

BMJ

117

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“…This period was followed in the cases of the four men by a second control period of 6-10 days. Estimations of urinary 17-KS and 17-ketogenic steroids (17-KGS) were carried out by the method of Gibson & Norymberski [1954] on each 24 hr specimen from cases 2 to 5. In case 1, only 17-KS were determined.…”

Section: Experimental Methodsmentioning

confidence: 99%

The SUPPRESSION OF ADRENOCORTICAL SECRETION WITH 17α-Ethyl-19-Nortestosterone

Brooks¹,

Prunty²

1957

Journal of Endocrinology

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Administration of 17\g=a\-ethyl-19-nortestosterone(50-100 mg/day) to four men with peptic ulcers caused a reduction in the excretion of 17-ketosteroids and 17-ketogenic steroids. All the major urinary 17-ketosteroids were decreased by this treatment, but 11\g=b\-hydroxyandrosterone appeared to be least affected.Single injections of androst-4-ene-3:17-dione were given to one patient both before and during the period of ethyl-nortestosterone treatment. Recovery of the metabolites of androstenedione in the 48 hr following injection was virtually the same in the pretreatment and treatment periods. This was interpreted to mean that alteration of the metabolism of this adrenal steroid was not the basis of the suppression of ketosteroid excretion.It is therefore concluded that 17\g=a\-ethyl-19-nortestosterone can cause suppression of adreno\x=req-\ cortical secretion.Ingle & Mason [1938] first demonstrated atrophy of the adrenal cortices of rats into which pellets of cortisone had been implanted. Since then many workers have found a depression of urinary 17-ketosteroid (17-KS) excretion in human individuals to whom cortisone has been administered. Recently a number of synthetic compounds, which possess some physiological properties similar to those of cortisone, have been shown to depress urinary 17-KS excretion. These include prednisone, prednisolone and their 9«-fluoro derivatives.There have also been reports of an adrenal-depressing action exerted by steroids more distantly related to the corticoids. Hoagland [1944] reported that pregnenolone injected intramuscularly in doses of 50-150 mg/day caused depression of urinary 17-KS. Partridge, Boling, De Wind, Margen & Kinsell [1953] found that androstenediol (1 g/day) caused a reduction of the 17-Carroll [1945] reported that administration of methyltestosterone caused a decrease in the urinary excretion of 17-KS of seven patients. One of those patients was a man with congenital absence of functioning testicular tissue and the remaining six were women. They also found a suggestive, but not conclusive, decrease in the 17-KS of two male patients with Addison's disease. Bartter, Forbes, Jefferies, Carroll & Albright [1949] established that methyltestosterone and testosterone propionate produced a fall in 17-KS and '11 oxysteroids' in certain females with Cushing's syndrome.The purpose of this paper is to describe some effects of 17 -ethyl-19-nortestosterone

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A Note on the Rapid Assay of 17-Ketogenic Steroids in Urine

Cited by 46 publications

References 2 publications

Hyperpigmentation of Skin

Hyperpigmentation of Skin

Defective Biosynthesis of Ovarian Steroids in the Stein-Leventhal Syndrome

The SUPPRESSION OF ADRENOCORTICAL SECRETION WITH 17α-Ethyl-19-Nortestosterone

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