We report on three cases of diastrophic dysplasia in second trimester fetuses and discuss the differential diagnosis and clinical, radiologic, and histopathologic findings. Manifestations of typical diastrophic dysplasia in infants and older patients include abnormal pinnae, scoliosis, and joint contractures; these were absent in the fetuses, in keeping with the tendency for the clinical and radiologic aspects of this disease to become more severe with age. The histopathologic characteristics of the cartilage appear to be similar in the fetus and older patient, and therefore may be useful in differentiating diastrophic dysplasia from other osteochondrodysplasias in the second trimester.
SYNOPSIS In 21 patients with megaloblastic anaemia associated with the tropical malabsorption syndrome serum vitamin B12 levels have been measured serially before and during parenteral folic acid therapy.In 11 patients there was a significant rise in serum B12 levels, reaching a peak three to 17 days after starting the folic acid. In three of these cases, absorption of labelled B12 was the same before and after the administration of folic acid. In two cases there was a fall in serum B12 levels and in seven there was no change. In one case small amounts of folic acid produced no change in serum B12 levels, whereas larger doses produced a prompt but transient rise.
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