“…We observed that the mean time to complete the task was significantly longer compared with age-matched and sex-matched normative data from healthy volunteers. 38 In previous studies, action tremor resulted in difficulties performing fine motor tasks (such as writing) and activities requiring gross motor coordination (such as attempting to hold and purposefully manipulate objects like a cup). 36 The name of this disease, as already known, cannot fully justify its anatomic origin.…”
Background: Spinocerebellar ataxia type 12 (SCA12) is a rare form of an autosomal-dominant ataxic disorder associated with an expansion of CAG repeat length. Here, we present a large case series of patients with SCA12 and describe a wide range of typical and rare symptoms. Methods: Twenty-one consecutive patients with genetically proven SCA12 underwent detailed neurological examination. We assessed clinical characteristics using validated rating scales for evaluating motor features in SCA. Nonmotor symptoms and quality of life were assessed using appropriate, validated scales. Correlations of CAG repeat length with both severity score and age of onset were explored. Results: The mean age of onset was 51 years, and most patients were descendants of a single, endogamous Indian community (Agarwal). Tremor was the most common initial presenting symptom (90%). Hand dystonia was present in 14 of 21 patients, and most patients in the cohort presented with gait disturbance. Neuropsychiatric manifestations were common coexisting features. The CAG repeat length was significantly correlated (r = À0.760; P = 0.0001) with early age of onset, but not with disease severity. Tremor affected the quality of life in 18 of 21 patients, because they had difficulty in handling liquids. Conclusions: Tremor was the most common, nonataxic symptom at initial presentation in patients with SCA12. Proximal upper limb tremor, typically with high amplitude and low frequency, can raise a strong diagnostic suspicion. Associated hand dystonia was a common coexisting motor feature. Various nonmotor features were also observed in several cases which require therapeutic attention.
“…We observed that the mean time to complete the task was significantly longer compared with age-matched and sex-matched normative data from healthy volunteers. 38 In previous studies, action tremor resulted in difficulties performing fine motor tasks (such as writing) and activities requiring gross motor coordination (such as attempting to hold and purposefully manipulate objects like a cup). 36 The name of this disease, as already known, cannot fully justify its anatomic origin.…”
Background: Spinocerebellar ataxia type 12 (SCA12) is a rare form of an autosomal-dominant ataxic disorder associated with an expansion of CAG repeat length. Here, we present a large case series of patients with SCA12 and describe a wide range of typical and rare symptoms. Methods: Twenty-one consecutive patients with genetically proven SCA12 underwent detailed neurological examination. We assessed clinical characteristics using validated rating scales for evaluating motor features in SCA. Nonmotor symptoms and quality of life were assessed using appropriate, validated scales. Correlations of CAG repeat length with both severity score and age of onset were explored. Results: The mean age of onset was 51 years, and most patients were descendants of a single, endogamous Indian community (Agarwal). Tremor was the most common initial presenting symptom (90%). Hand dystonia was present in 14 of 21 patients, and most patients in the cohort presented with gait disturbance. Neuropsychiatric manifestations were common coexisting features. The CAG repeat length was significantly correlated (r = À0.760; P = 0.0001) with early age of onset, but not with disease severity. Tremor affected the quality of life in 18 of 21 patients, because they had difficulty in handling liquids. Conclusions: Tremor was the most common, nonataxic symptom at initial presentation in patients with SCA12. Proximal upper limb tremor, typically with high amplitude and low frequency, can raise a strong diagnostic suspicion. Associated hand dystonia was a common coexisting motor feature. Various nonmotor features were also observed in several cases which require therapeutic attention.
“…The participants pick up the pegs to place them into the holes, then remove them from the holes with either left or right hand as fast as possible. The evaluator will record time to complete the assessment [60]. If the participants cann't place nine pegs into the holes within one minute, they will be asked not to continue the test [61].…”
Background An important reason for the difficulty in recovering sensorimotor dysfunction of the upper extremity in chronic stroke survivors, is the lack of sensory function, such as tactile and proprioception feedback. In clinical practice, single sensory training is only for the restoration of sensory function. Increasing evidence suggests that use of task-oriented training (TOT) is a useful approach to hand motor rehabilitation. However, neither approach is optimal since both methods are trained only for specific functional recovery. Our hypothesis is that multi-sensory feedback therapy (MSFT) combined with TOT has the potential to provide stimulating tasks to restore both sensory and motor functions. The objective of the trial is to investigate whether novel MSFT is more effective in improving arm sensorimotor function in chronic stroke phase than single TOT.Methods/Design: The study will be conducted as a multicenter, randomized, double blind controlled trial. Participants (n = 90) will be randomised into three groups to compare the effect of the multi-sensory feedback therapy group against task-oriented training group and conventional group. Participants will receive treatment at the same intensity (60 min, 5 days a week, 4 weeks, 20 hours total). Primary outcome measures for assessment of sensory function are the Semmes Weinstein monofilaments examination (SWME),two-point discrimination test (2PD) test. Secondary measures are the Action Research Arm Test (ARAT)༌Nine-Hole Peg Test (NHPT), Wolf Motor Function Test (WMFT), Box and Blocks Test (BBT), Modified Barthel Index (MBI), Instrumental activities of daily living (IADL) and Generalized Anxiety Disorder 7-Item Scale (GAD-7). Outcome mearsures will be evaluated at baseline, post treatment, and two months follow-up. All assessments will be conducted by trained assessors blinded to treatment allocation.Discussion This study will determine the acceptability and efficacy of the intervention on the hemiparetic upper limb, it may be promising tools for sensorimotor functional recovery after stroke.
“…Presenta una fiabilidad test/retest (ICC = 0,95 para mano derecha, ICC = 0,92 para mano izquierda). Fiabilidad interobservador para mano derecha (r=0,984) y para mano izquierda (r=0,993) (Lindstrom-Hazel et al, 2015).…”
Introducción: El envejecimiento es un proceso universal que conduce a un deterioro funcional y a la pérdida de la capacidad de adaptación de manera progresiva. En España hay actualmente casi nueve millones de personas mayores.
Objetivo: Determinar la relación existente entre el funcionamiento cognitivo, la función sensitiva de estereognosia y la destreza manipulativa en personas mayores en ausencia de deterioro cognitivo diagnosticado.
Diseño: Investigación básica, observacional, descriptiva, transversal, de corte prospectivo y de naturaleza cuantitativa.
Participantes: 28 participantes (n=28).
Intervenciones: Se llevó a cabo una única evaluación en un único momento. La recogida de muestra se realizó entre los meses de febrero y abril de 2019. El proceso de evaluación constó de tres pruebas que se administraron siguiendo un orden determinado: Dynamic Loewenstein Occupational Therapy Cognitive Assessment For Geriatric Use (DLOTCA-G) para evaluar funciones cognitivas, subprueba de estereognosia del Nottingham Sensory Assessment (NSA) y Nine Hole Peg Test (9HPT) para evaluar la destreza manipulativa.
Resultados: Se obtuvo como resultado que existe una relación entre el aumento de edad y el empeoramiento de la destreza manipulativa, hallándose una débil correlación entre la puntuación en pruebas que evalúan la memoria y el tiempo empleado en completar pruebas de destreza manipulativa y que existe una relación entre la edad y las puntuaciones de las pruebas cognitivas que requieren secuenciación y construcción en dos dimensiones.
Conclusión: Las personas mayores obtuvieron tiempos más altos y variables en las pruebas de estereognosia y tienen mayor probabilidad de no reconocer todos los objetos o la forma de los mismos.
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