A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes

Major, Terry C.; Olszewski, Bronia; Rosebury, Wendy S.; Okerberg, Carlin V.; Carlson, Tage; Ostroski, Robert; Schroeder, Richard L.; Kowala, Mark C.; Leadley, Robert J.

doi:10.1007/s10557-008-6131-x

Cited by 9 publications

(12 citation statements)

References 39 publications

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“…Similar changes were observed with the ACE inhibitors enalapril and captopril [86,88]. Likewise, LV hypertrophy and LV mass were significantly reduced in spontaneously hypertensive rats and double transgenic mice following treatment with a rat renin inhibitor or a nonpeptide piperidine renin inhibitor, respectively [70,89].…”

Section: Effects Of Direct Renin Inhibitors On Cardiac Hemodynamic Pasupporting

confidence: 61%

“…A nonpeptide piperidine renin inhibitor decreased GFR to normal levels in double transgenic mice expressing the human renin and angiotensinogen genes [70]. In a study in diabetic Munich-Wistar-Fromter rats, aliskiren reduced SNGFR and glomerular diameter compared with vehicle [71].…”

Section: Renoprotective Effects Of Direct Renin Inhibitorsmentioning

confidence: 99%

“…However, studies of a nonpeptide piperidine DRI and aliskiren in rats have suggested renal protective effects of DRIs (supplementary Table S1). UACR was significantly reduced following administration of a nonpeptide piperidine DRI (100 mg/kg per day) to transgenic mice expressing human renin [70]. Albuminuria was reduced and/or prevented in diabetic and nondiabetic rats treated with intraperitoneal or subcutaneous aliskiren at doses of 0.03-50 mg/kg per day [71,[73][74][75][76][77].…”

Section: Renoprotective Effects Of Direct Renin Inhibitorsmentioning

confidence: 99%

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Renal and cardio-protective effects of direct renin inhibition: a systematic literature review

Heerspink

Perkovic

Zeeuw

2009

Journal of Hypertension

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Section: Effects Of Direct Renin Inhibitors On Cardiac Hemodynamic Pasupporting

confidence: 61%

Section: Renoprotective Effects Of Direct Renin Inhibitorsmentioning

confidence: 99%

Section: Renoprotective Effects Of Direct Renin Inhibitorsmentioning

confidence: 99%

See 1 more Smart Citation

Renal and cardio-protective effects of direct renin inhibition: a systematic literature review

Heerspink

Perkovic

Zeeuw

2009

Journal of Hypertension

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“…Piperidine is known for its role as renin inhibitors providing cardiac protection. [64,65] Protein extracts from plants are the important raw material in food, pharmaceutical, and cosmetic industries. [66,67] Seed extracts of longan exhibited a marked abundance of amino acids, including L-Phenylalanine, L-Arginine, N-acetylglycine, known for their beneficial properties, i.e., wound healing, assisting in removing waste products from kidney, and muscle relaxant.…”

Section: Discussionmentioning

confidence: 99%

A comprehensive insight into the metabolic landscape of fruit pulp, peel, and seed in two longan (Dimocarpus longanLour.) varieties

Wang

Guo

Han

et al. 2020

International Journal of Food Properties

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Longan is an ancient and popular plant with highly nutritious fruit. The pulp is the main part of the fruit which is consumed. However, the potentials of other longan fruit parts such as the peel and the seed as reservoirs of important bioactive components have not yet fully been explored. This study aimed at exploring the diversity of primary and secondary metabolites in two commercial longan varieties, i.e., Shixia and Chuliang, concerning fruit, pulp, peel, and seed based on a widely targeted metabolomics approach. A total of 706 metabolites were identified grouped into eight diverse classes of metabolites, including flavonoids, amino acids and its derivatives, alkaloids, tannins, phenolic acids, organic acids, nucleotides and derivatives, lipids, and lignans. Chuliang peel showed a higher accumulation of metabolites viz. flavonoids, alkaloids, and tannins, while Shixia seeds showed abundance in amino acids, organic acid, nucleic acids and its derivatives. Chuliang pulp showed relatively higher accumulation of lipids when compared with other fruit parts. Differential metabolome profiling between fruit parts indicates the prevalence of key metabolites, i.e., O-Phosphocholine, betaine, piperidine, L-Arginine, and L-Phenylalanine, in seed and peel of the longan fruit. The findings in this research provide a new glance on the nutritional value and biochemical basis of longan fruit pharmaceutical value, with emphasis on valorization of longan peel and seed tissues for their pharmaceutical properties and nutritional values.

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“…The haemodynamic changes in this model have been well characterized previously 15 . Briefly, transgenic mice were prepared with in‐dwelling aortic catheters and radiotransmitters (Data Sciences International, St Paul, MN, USA).…”

Section: Methodsmentioning

confidence: 99%

Cellular Expression of Renal, Cardiac and Pulmonary Inducible Nitric Oxide Synthase in Double‐transgenic Mice Expressing Human Renin and Angiotensinogen Genes

Radi

Murad

2009

Clin Exp Pharma Physio

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1. Hypertensive mice expressing the human renin (REN) and angiotensinogen (AGT) genes are used as a model for human hypertension. 2. The aim of the present study was to investigate the cellular expression and distribution of inducible nitric oxide synthase (iNOS) using immunohistochemistry in lung, heart and kidney tissues from a model of human hypertension using male and female double-transgenic (h-Ang 204/1h-Ren6) mice and wild-type C57/BI6J mice as controls. 3. In the kidney, the pattern of iNOS expression in various renal microanatomical regions during hypertension was similar to that of age-matched controls, except in the medullary ascending limb (MAL). In hypertension, iNOS expression was downregulated in the MAL. No significant differences in iNOS expression were seen between control or hypertensive mice in various cardiac microanatomical locations. In the lungs of hypertensive mice, iNOS expression was upregulated in bronchial airway epithelium and bronchial and vascular smooth muscle cells, but downregulated in alveolar macrophages, alveolar septa and pulmonary vascular endothelial cells. Expression of iNOS was similar between male and female mice in the kidney, heart and lungs. 4. In conclusion, iNOS regulation in hypertension is complex and depends on the cell type in which it is expressed and the localization of the cell type in the cardiorenal and pulmonary systems.

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A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes

Cited by 9 publications

References 39 publications

Renal and cardio-protective effects of direct renin inhibition: a systematic literature review

Renal and cardio-protective effects of direct renin inhibition: a systematic literature review

A comprehensive insight into the metabolic landscape of fruit pulp, peel, and seed in two longan (Dimocarpus longanLour.) varieties

Cellular Expression of Renal, Cardiac and Pulmonary Inducible Nitric Oxide Synthase in Double‐transgenic Mice Expressing Human Renin and Angiotensinogen Genes

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