A Nitric Oxide Synthesis Inhibitor Administered Into the Medial Preoptic Area Increases Seminal Emissions in an Ex Copula Reflex Test

Moses, Jason; Hull, Elaine M.

doi:10.1016/s0091-3057(98)00252-4

Cited by 26 publications

(11 citation statements)

References 21 publications

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“…These results suggest that NO generated in or near the AV3V may act to regulate the vasopressin release, arterial pressure and heart rate but it may not play an essential role in eliciting the responses of these variables to osmotic or prostaglandin E (2) stimuli as previously described by (Yamaguchi et al, 2000). Our findings are consistent with other hypothesis that NO is a tonic inhibitor of sympathetic nervous system tone, possibly in part through an influence on dopamine synthesis or release as has been demonstrated in the studies of (Moses and Hull, 1999). Ascending pathways from medial hypothalamus or LH to AV3V region were suggested by studies from our laboratory using cholinergic activation of these nuclei (Valadão et al, 1992).…”

Section: Discussionsupporting

confidence: 90%

Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats

et al. 2004

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Section: Discussionsupporting

confidence: 90%

Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats

et al. 2004

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“…increased mounting rate. In addition, Moses and Hull (1999) found that microinjection of L-NMMA into the MPOA significantly decreased the latency to the first erection or seminal emission and increased the number of seminal emissions in male rats. Both of those effects were hypothesized to result from enhanced sympathetic nervous system activity.…”

Section: Discussionmentioning

confidence: 95%

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Lagoda

Muschamp

Vigdorchik

et al. 2004

Behavioral Neuroscience

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Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation in sexually experienced males. In other naive rats, L-NAME or saline was microinjected into the MPOA before each of 7 daily exposures to a receptive female placed over their cage. In a drug-free test on Day 8, copulation by L-NAME-treated rats was similar to that of unexposed controls and was impaired relative to saline-treated males. Therefore, NO in the MPOA is important for copulation and stimulus sensitization in male rats.

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“…Interestingly, the THF-diols, but not the LTX-diols, block male sexual behavior (Mani et al 2005; Markaverich et al 2005). The mechanism of action of these compounds remains to be resolved, although we suspect their effects on estrous cyclicity and sexual behavior in male and female rats are mediated via the modulation of nitric oxide–dependent pathways controlling gonadotrophin-releasing hormone release (Hull et al 1994; Ishizaki et al 1995a, 1995b; Moses and Hull 1999). The present studies support a common mechanism of action.…”

Section: Discussionmentioning

confidence: 99%

Tetrahydrofurandiols (THF-diols), Leukotoxindiols (LTX-diols), and Endocrine Disruption in Rats

Markaverich

Alejandro²,

Thompson³

et al. 2007

Environ Health Perspect

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BackgroundGround corncob animal bedding and corn food products contain substances that disrupt endocrine function in rats. The disruptors were identified as isomeric mixtures of tetrahydrofurandiols (THF-diols; 9,12-oxy-10,13-dihydroxyoctadecanoic acid and 10,13-oxy-9,12-dihydroxyoctadecanoic acid) and leukotoxindiols (LTX-diols; 9,10-dihydroxy-12-octadecenoic acid and 12,13-dihydroxy-9-octadecenoic acid). The authentic compounds blocked sexual behavior in male rats and estrous cyclicity in female rats at oral doses of 2 ppm.ObjectivesTo define the lowest observed adverse effect level (LOAEL) for the THF-diols and LTX-diols in rats, we examined the nature of their interaction (additive or synergistic) and quantified the concentration of THF-diols in rat tissues.MethodsAdult male and female rats were provided drinking solutions containing various doses of THF-diols and/or LTX-diols, and we evaluated their effects on male sexual behavior and female estrous cyclicity. Tissues were collected for THF-diol determination by gas chromatography–mass spectrometry.ResultsThe LOAEL for THF-diols and LTX-diols for blocking estrous cyclicity was 0.5–1.0 ppm and 0.2–0.5 ppm, respectively. Higher concentrations (1–2 ppm) of THF-diols were required to block male sexual behavior. Combination studies with subthreshold doses of 0.05 ppm THF-diols plus 0.05 ppm LTX-diols revealed that their effects on estrous cyclicity were not synergistic. We were unable to detect THF-diols in tissues from rats treated with 10 ppm of the compounds, suggesting that metabolism may be involved.DiscussionTHF-diols, LTX-diols, and/or their metabolites likely act additively to disrupt endocrine function in male and female rats at concentrations (0.5–1 ppm) that are 200-fold lower than those of classical phytoestrogen endocrine disruptors.

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A Nitric Oxide Synthesis Inhibitor Administered Into the Medial Preoptic Area Increases Seminal Emissions in an Ex Copula Reflex Test

Cited by 26 publications

References 21 publications

Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats

Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Tetrahydrofurandiols (THF-diols), Leukotoxindiols (LTX-diols), and Endocrine Disruption in Rats

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