Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats

Saad, Wilson Abrão; Guarda, Ismael Francisco Motta Siqueira; Camargo, Luiz Antônio de Arruda; Garcı́a, Gustavo; Gutierrez, Laura Izabel; Saad, William Abrão; Simões, Silvio Jorge Coelho; Guarda, Renata Saad

doi:10.1016/j.lfs.2004.01.018

Cited by 19 publications

(6 citation statements)

References 40 publications

(45 reference statements)

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“…In addition, these data show that angiotensinergic stimulation in rats pretreated with L-NAME had potentiated arterial blood pressure and water and sodium intake. Our findings are consistent with other studies, which also showed that central inhibition of NOS enhances ANG-II-induced thirst and sodium appetite [20,26]. …”

Section: Discussionsupporting

confidence: 94%

“…Several studies have shown that NO is synthesized tonically within the brain during conditions of normal water balance because water and sodium intake increases when endogenous production of NO is inhibited by injection of L-NAME into and around the structures surrounding third ventricle [20,26,35]. In this way, we found that icv injection of L-NAME induces an increase in water and sodium intake.…”

Section: Discussionsupporting

confidence: 52%

“…It was reported that L-arginine had an antidipsogenic effect when administered centrally to rats deprived of water or stimulated by ANG-II [21]. Other NO donors used in the literature also indicated that the nitrergic system exerts an inhibitory effect on ANG-II-induced VP and OT release and blood pressure [20,22,35]. Therefore, taken together, the present results suggest the inhibitory action of NO system on the effects of ANG-II on neuroendocrine responses, hydromineral balance and blood pressure maintenance.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the inhibition of endogenous NOS enhances drinking behavior and cardiovascular responses induced by the central administration of ANG II [4,19]. On the other hand, L-arginine, a precursor of NO, as well as NO donors, were able to reduce VP and OT release, water intake, blood pressure, diuretic and natriuretic effects of central angiotensinergic stimulation [4,20-22]. …”

Section: Introductionmentioning

confidence: 99%

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Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

Reis

Saad

Camargo

et al. 2010

Behavioral and Brain Functions

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BackgroundNitric oxide (NO) synthesis has been described in several circumventricular and hypothalamic structures in the central nervous system that are implicated in mediating central angiotensin-II (ANG-II) actions during water deprivation and hypovolemia. Neuroendocrine and cardiovascular responses, drinking behavior, and urinary excretions were examined following central angiotensinergic stimulation in awake freely-moving rats pretreated with intracerebroventricular injections of Nω-nitro-L-arginine methyl ester (L-NAME, 40 μg), an inhibitor of NO synthase, and L-arginine (20 ug), a precursor of NO.ResultsInjections of L-NAME or ANG-II produced an increase in plasma vasopressin (VP), oxytocin (OT) and atrial natriuretic peptide (ANP) levels, an increase in water and sodium intake, mean arterial blood pressure and sodium excretion, and a reduction of urinary volume. L-NAME pretreatment enhanced the ANG-II response, while L-arginine attenuated VP and OT release, thirst, appetite for sodium, antidiuresis, and natriuresis, as well as pressor responses induced by ANG-II.Discussion and conclusionThus, the central nitrergic system participates in the angiotensinergic responses evoked by water deprivation and hypovolemia to refrain neurohypophysial secretion, hydromineral balance, and blood pressure homeostasis.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

Reis

Saad

Camargo

et al. 2010

Behavioral and Brain Functions

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“…Second, older adults showed lower brain activation as compared to young adults in the lateral hypothalamus in response to salty and bitter tastes, and showed increased preference for salty but not bitter stimuli. This is in agreement with the finding that lesions in the lateral hypothalamus result in changes in salt preference (Abrão Saad et al, 2004;Da Silva et al, 1995). Based on our results, we consider that homeostatic mechanisms underlie taste quality specificity in age related differences in taste processing.…”

Section: Age and Taste Qualitysupporting

confidence: 93%

Neural processing of basic tastes in healthy young and older adults — an fMRI study

et al. 2015

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Ageing affects taste perception as shown in psychophysical studies, however, underlying structural and functional mechanisms of these changes are still largely unknown. To investigate the neurobiology of age-related differences associated with processing of basic tastes, we measured brain activation (i.e. fMRI-BOLD activity) during tasting of four increasing concentrations of sweet, sour, salty, and bitter tastes in young (average 23 years of age) and older (average 65 years of age) adults. The current study highlighted age-related differences in taste perception at the different higher order brain areas of the taste pathway. We found that the taste information delivered to the brain in young and older adults was not different, as illustrated by the absence of age effects in NTS and VPM activity. Our results indicate that multisensory integration changes with age; older adults showed less brain activation to integrate both taste and somatosensory information. Furthermore, older adults directed less attention to the taste stimulus; therefore attention had to be reallocated by the older individuals in order to perceive the tastes. In addition, we considered that the observed age-related differences in brain activation between taste concentrations in the amygdala reflect its involvement in processing both concentration and pleasantness of taste. Finally, we state the importance of homeostatic mechanisms in understanding the taste quality specificity in age related differences in taste perception.

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Nitric oxide pathway is an important modulator of heat loss in rats during exercise

Lacerda

Marubayashi

Coimbra

2005

Brain Research Bulletin

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Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats

Cited by 19 publications

References 40 publications

Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

Neural processing of basic tastes in healthy young and older adults — an fMRI study

Nitric oxide pathway is an important modulator of heat loss in rats during exercise

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