A nitric oxide responsive AIE probe for detecting the progression of osteoarthritis

Abstract

An AIE probe was established for reacting with NO and emitting fluorescence in arthritic joints/chondrocytes. This AIE probe is appropriate for detecting the progression of osteoarthritis.

Recent progress of organic fluorescent molecules for bioimaging applications: cancer-relevant biomarkers

“…It was derived from tetraphenylethylene (TPE) modified with a hydrophilic-group polyethylene glycol chain and anti-inflammatory drug diacerein to improve water solubility and poor fluorescence. 40,41 The o-phenylenediamine group was selec- Reproduced with permission. 38 Copyright 2019, Royal Society of Chemistry.…”

“…It was derived from tetraphenylethylene (TPE) modified with a hydrophilic-group polyethylene glycol chain and anti-inflammatory drug diacerein to improve water solubility and poor fluorescence. 40,41 The o -phenylenediamine group was selectively reacted with NO to form a benzotriazole group and produce a strong red fluorescence signal. The results showed that the NO-responsive AIE probe can monitor the progression of OA in vivo and in vitro during with fluorescence response change.…”

“…This work provided a new development direction for early clinical OA diagnosis and treatment using AIE fluorescence molecules. 40…”

“…The results showed that the NO-responsive AIE probe can monitor the progression of OA in vivo and in vitro during with fluorescence response change. This work provided a new development direction for early clinical OA diagnosis and treatment using AIE fluorescence molecules 40.…”

An “AIE + ESIPT” mechanism-based benzothiazole-derived fluorescent probe for the detection of Hg2+and its applications

“…The concept of aggregation-induced emission (AIE), as proposed by Tang's group, 20 refers to some luminescent molecules such as benzothiazole, 21,22 tetraphenylethene, [23][24][25][26] and triphenylamine [27][28][29] that could display intense fluorescent emission behavior in the aggregated state due to the restriction of intramolecular motions (RIM). On the other hand, excitedstate intramolecular proton transfer (ESIPT), first reported by Weller in the 1995, involves emission by fast intramolecular proton transfer via the extremely fast enol-keto tautomeric transformation between the ground state and excited state upon photoexcitation with the advantages of good photostability and large Stokes shifts, thereby avoiding the adverse effect of self-absorption and inner-filter.…”