A nicotinic acid ester and experimental atherosclerosis No significant effect of treatment with niceritrol (pentaerythritoltetranicotinate) on cholesterol in aorta of rabbits previously fed with cholesterol-enriched diet

Stender, Steen; Astrup, Poul; Brattsand, Ralph

doi:10.1016/0021-9150(76)90010-1

Cited by 3 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enhance autophagy Stender et al (1976) 1412 D. WANG et al demonstrated that TXL could promote autophagy and protect CMECs against I/R induced apoptosis via the MEK/ERK pathway. Shuangshenningxin (SSNX) has shown beneficial effects in modulating the energy metabolism of the myocardium and also in vascular protection (Yu et al, 2007).…”

Section: Lc3-ii P62mentioning

confidence: 99%

Roles of Autophagy in Ischemic Heart Diseases and the Modulatory Effects of Chinese Herbal Medicine

et al. 2017

View full text Add to dashboard Cite

Autophagy is an evolutionarily conserved degradation process which eliminates dysfunctional proteins and cytoplasmic components to maintain homeostasis for cell survival. Increasing evidence has demonstrated the modulatory role of autophagy in ischemic heart diseases (IHDs). Traditionally, this process has been recognized as having protective functions, such as inhibiting atherosclerosis progression and reducing cell death during the ischemic phase. However, recent studies have suggested its dual roles in myocardial ischemia/reperfusion (MIR) injury. Excessive autophagy may play a deleterious role in cardiac function, due to overwhelming clearance of cellular constituents and proteins. Hence modulation of autophagy to increase cardiomyocyte survival and improve cardiac function is meaningful for the treatment of IHD. Chinese herbal medicine, including extractive compounds and patented drugs, has shown its potential role in treating IHD by addressing autophagy-related mechanisms. This review summarizes the updated knowledge on the molecular basis and modulatory role of autophagy in IHD and the recent progress of Chinese herbal medicine in its treatment.

show abstract

Section: Lc3-ii P62mentioning

confidence: 99%