Comparative evaluation of some pharmacological properties and side effects of d-glucitol hexanicotinate (sorbinicate) and nicotinic acid correlated with the plasma concentration of nicotinic acid

Subissi, Alessandro; Schiantarelli, P; Biagi, Mark; Sardelli, G

doi:10.1016/0021-9150(80)90207-5

Cited by 9 publications

(2 citation statements)

References 36 publications

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“…Side effects of high levels of treatment, such as 300 mg of nicotinic acid/kg of BW/day for 3 weeks, have been observed in the normocholesterolemic rat. These include rebounds in plasma-free fatty acids and triglycerides, and triglyceride accumulation in liver (Subissi et al, 1980). Although the hypolipidemic effect of nicotinamide appears to be much less than that of nicotinic acid, studies in rats (Dalton et al, 1970) have shown that because of the much longer serum half-life of nicotinamide, its hypolipidemic effect is much longer.…”

Section: Hypervitaminosismentioning

confidence: 99%

Vitamin Tolerance of Animals

1987

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Section: Hypervitaminosismentioning

confidence: 99%

Vitamin Tolerance of Animals

1987

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“…Therefore, independent of any lipid-lowering activity, MDL 293 1 1 has only modest primary antiatherosclerotic activity. Regarding the triglyceride-raising activity of MDL 29311 in the modified Watanabe rabbit, it should be noted that two commonly used triglyceride-lowering agents in clinical practice, clofibrate and nicotinic acid, increase or have no effect on plasma triglycerides in rabbits (5,43).…”

Section: Introductionmentioning

confidence: 99%