A New Xanthone O-Glycoside from the Mangrove Endophytic Fungus Phomopsis sp.

Zhong-jing, Huang; Yang, Jianxiang; Lei, Fuhou; She, Zhigang; Lin, Yongcheng

doi:10.1007/s10600-013-0497-0

Cited by 20 publications

(12 citation statements)

References 9 publications

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“…(ZH76) from the stems of the mangrove tree Excoecaria agallocha contained a new O -glycoside compound, 3- O -(6- O - α -L-arabinopyranosyl)- β -D-glucopyranosyl-1,4-dimethoxyxanthone ( 27 ). The IC 50 values of cytotoxicity for compound 27 on HEp-2 and HepG2 cells were 9 and 16 μmol/mL, respectively [ 30 ]. Phomoxanthone A ( 28 ), a dimeric tetrahydroxanthone, was extracted from P .…”

Section: Bioactive Secondary Metabolites From Phomopsis mentioning

confidence: 99%

Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019

Wang

et al. 2021

Microorganisms

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The genus Diaporthe and its anamorph Phomopsis are distributed worldwide in many ecosystems. They are regarded as potential sources for producing diverse bioactive metabolites. Most species are attributed to plant pathogens, non-pathogenic endophytes, or saprobes in terrestrial host plants. They colonize in the early parasitic tissue of plants, provide a variety of nutrients in the cycle of parasitism and saprophytism, and participate in the basic metabolic process of plants. In the past ten years, many studies have been focused on the discovery of new species and biological secondary metabolites from this genus. In this review, we summarize a total of 335 bioactive secondary metabolites isolated from 26 known species and various unidentified species of Diaporthe and Phomopsis during 2010–2019. Overall, there are 106 bioactive compounds derived from Diaporthe and 246 from Phomopsis, while 17 compounds are found in both of them. They are classified into polyketides, terpenoids, steroids, macrolides, ten-membered lactones, alkaloids, flavonoids, and fatty acids. Polyketides constitute the main chemical population, accounting for 64%. Meanwhile, their bioactivities mainly involve cytotoxic, antifungal, antibacterial, antiviral, antioxidant, anti-inflammatory, anti-algae, phytotoxic, and enzyme inhibitory activities. Diaporthe and Phomopsis exhibit their potent talents in the discovery of small molecules for drug candidates.

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Section: Bioactive Secondary Metabolites From Phomopsis mentioning

confidence: 99%

Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019

Wang

et al. 2021

Microorganisms

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“…Xanthone glycosides are mainly isolated from plants such as Gentianaceae and Guttiferae [32,33] but are rarely reported from fungi, except for Phomopsis sp. ZH76 [34], Paecilomyces cinnamomeus BCC 9616 [35], and Aschersonia coffeae Henn. Bcc 28712 [36].…”

Section: Discussionmentioning

confidence: 99%

A New Xanthone Glycoside from the Endolichenic Fungus Sporormiella irregularis

Yang

Chen

et al. 2016

Molecules

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Abstract:A new xanthone glycoside, sporormielloside (1), was isolated from an EtOAc extract of an endolichenic fungal strain Sporormiella irregularis (No. 71-11-4-1), along with two known xanthones (2, 3). Their structures were determined by detailed spectroscopic analysis (IR, MS, and 1D-and 2D-NMR), a chemical method, and a comparison of NMR data with closely related compounds previously reported. According to the structures of isolated compounds, their plausible biosynthetic pathway was deduced.

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“…Its chemical structure was determined on the basis of spectroscopic data. Compound (116) inhibited the growth of HEp-2 and HepG2 cells with the IC 50 values of 9 and 16 μM respectively (Huang et al, 2013 ). Mangrove fungus Aspergillus terreus (No.…”

Section: Compounds From Mangrove Endophytic Fungimentioning

confidence: 99%

Marine Fungi: A Source of Potential Anticancer Compounds

2018

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Metabolites from marine fungi have hogged the limelight in drug discovery because of their promise as therapeutic agents. A number of metabolites related to marine fungi have been discovered from various sources which are known to possess a range of activities as antibacterial, antiviral and anticancer agents. Although, over a thousand marine fungi based metabolites have already been reported, none of them have reached the market yet which could partly be related to non-comprehensive screening approaches and lack of sustained lead optimization. The origin of these marine fungal metabolites is varied as their habitats have been reported from various sources such as sponge, algae, mangrove derived fungi, and fungi from bottom sediments. The importance of these natural compounds is based on their cytotoxicity and related activities that emanate from the diversity in their chemical structures and functional groups present on them. This review covers the majority of anticancer compounds isolated from marine fungi during 2012-2016 against specific cancer cell lines.

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A New Xanthone O-Glycoside from the Mangrove Endophytic Fungus Phomopsis sp.

Cited by 20 publications

References 9 publications

Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019

Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019

A New Xanthone Glycoside from the Endolichenic Fungus Sporormiella irregularis

Marine Fungi: A Source of Potential Anticancer Compounds

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