A new uridine derivative and a new indole derivative from the coral-associated actinomycete <i>Pseudonocardia</i> sp. SCSIO 11457

Fang, Zhuangjie; Chen, Siqiang; Zhu, Yiguang; Li, Jie; Khan, Imran; Zhang, Qingbo

doi:10.1080/14786419.2019.1616729

Cited by 13 publications

(18 citation statements)

References 21 publications

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“…In addition, compounds 60 and 64 showed moderate activity against four cell lines (A549, BGC823, HCT116, HepG2) with the IC 50 values ranging from 5.33 µM to 19.7 µM, and also exhibited the most potent antitumor activity against U87MG cell line with IC 50 values of 0.50 µM and 2.42 µM, respectively. On comparing the structure and activity of analogs (60)(61)(62)(63)(64), it was found that the modification of the tetronolide skeleton affected the in vitro antitumor activity to some extent. Tetrocarcin F1 (S24) was inactive, indicating that the sugar moiety at C-9 position could play an important role in the antitumor activity.…”

Section: Alkaloidsmentioning

confidence: 99%

Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.

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Section: Alkaloidsmentioning

confidence: 99%

Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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“…Finally, uradine is interesting, as this metabolite may well be important to the coral holobiont but appears to be associated more with the corals' microbiome rather than the host itself. Fang et al (2019) showed that uradine has high antibacterial capabilities against pathogenic bacteria and is derived from a coral associated actinomycete (Fang et al, 2019). Increased amounts of uridine in thermally stressed corals could indicate a response of the coral holobiont to rising temperatures, acting as a line of defense in preparation for disease infection and is therefore worthy of further investigation in this regard.…”

Section: Discussionmentioning

confidence: 99%

Species-Specific Variations in the Metabolomic Profiles of Acropora hyacinthus and Acropora millepora Mask Acute Temperature Stress Effects in Adult Coral Colonies

et al. 2021

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Coral reefs are suffering unprecedented declines in health state on a global scale. Some have suggested that human assisted evolution or assisted gene flow may now be necessary to effectively restore reefs and pre-condition them for future climate change. An understanding of the key metabolic processes in corals, including under stressed conditions, would greatly facilitate the effective application of such interventions. To date, however, there has been little research on corals at this level, particularly regarding studies of the metabolome of Scleractinian corals. Here, the metabolomic profiles [measured using 1H nuclear magnetic resonance spectroscopy (1H NMR) and ultra-high-performance liquid chromatography-mass spectrometry (LC-MS)] of two dominant reef building corals, Acropora hyacinthus and A. millepora, from two distinct geographical locations (Australia and Singapore) were characterized. We assessed how an acute temperature stress (an increase of 3.25°C ± 0.28 from ambient control levels over 8 days), shifted the corals’ baseline metabolomic profiles. Regardless of the profiling method utilized, metabolomic signatures of coral colonies were significantly distinct between coral species, a result supporting previous work. However, this strong species-specific metabolomic signature appeared to mask any changes resulting from the acute heat stress. On closer examination, we were able to discriminate between control and temperature stressed groups using a partial least squares discriminant analysis classification model (PLSDA). However, in all cases “late” components needed to be selected (i.e., 7 and 8 instead of 1 and 2), suggesting any treatment effect was small, relative to other sources of variation. This highlights the importance of pre-characterizing the coral colony metabolomes, and of factoring that knowledge into any experimental design that seeks to understand the apparently subtle metabolic effects of acute heat stress on adult corals. Further research is therefore needed to decouple these apparent individual and species-level metabolomic responses to climate change in corals.

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“…SCSIO 11457, a CAB from the stony coral Galaxea fascicularis (Fang et al . 2019). All three compounds, termed nucleoside antibiotics, show low antibacterial activity against the human pathogens S. aureus , MRSA, and Acinetobacter baumannii , and the coral pathogen V. alginolyticus (Fang et al .…”

Section: Secondary Metabolites From Cabmentioning

confidence: 99%

“…All three compounds, termed nucleoside antibiotics, show low antibacterial activity against the human pathogens S. aureus , MRSA, and Acinetobacter baumannii , and the coral pathogen V. alginolyticus (Fang et al . 2019). The antibacterial activity of the three compounds increased in the presence of bacterial symbionts of G. fascicularis , showing how combined effects of bacteria can increase the resistance of corals to pathogens in a system (Fang et al .…”

Section: Secondary Metabolites From Cabmentioning

confidence: 99%

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Ecological and biotechnological importance of secondary metabolites produced by coral‐associated bacteria

et al. 2020

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Summary Symbiotic relationships between corals and their associated micro‐organisms are essential to maintain host homeostasis. Coral‐associated bacteria (CAB) can have different beneficial roles in the coral metaorganism, such as metabolizing essential nutrients for the coral host and protecting the coral from pathogens. Many CAB exert these functions via secondary metabolites, which include antibacterial, antifouling, antitumour, antiparasitic and antiviral compounds. This review describes how analysis of CAB has led to the discovery of secondary metabolites with potential biotechnological applications. The most commonly found types of secondary metabolites, antimicrobial and antibiofilm compounds, are emphasized and described. Recently developed methods that can be applied to enhance the culturing of CAB from shallow‐water reefs and the less‐studied deep‐sea coral reefs are also discussed. Last, we suggest how the combined use of meta‐omics and innovative growth‐diffusion techniques can vastly improve the discovery of novel compounds in coral environments.

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A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457

Cited by 13 publications

References 21 publications

Natural Products from Actinomycetes Associated with Marine Organisms

Natural Products from Actinomycetes Associated with Marine Organisms

Species-Specific Variations in the Metabolomic Profiles of Acropora hyacinthus and Acropora millepora Mask Acute Temperature Stress Effects in Adult Coral Colonies

Ecological and biotechnological importance of secondary metabolites produced by coral‐associated bacteria

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