A New Type of Renal Cancer—Tubulocystic Carcinoma of the Kidney

Abstract

In 2004, A new peculiar subtype of renal cell carcinoma, which later received the name of tubulocystic carcinoma (TCC-RC), was recognized. Though the tumor has distinct macroscopic, microscopic and immunohistochemical features, the tumor was previously considered to have some similarities to various other renal cancers. We did an extensive review of literature using PubMed and CrossRef, which yielded more than 80 cases reported from various parts of the world. We evaluated the epidemiology, tumor presentations, pathological characteristics, treatment, and outcome of TCC-RC.

Genome-wide methylation analysis of tubulocystic and papillary renal cell carcinomas

“…Mostly, such tumors are composed of tubules and cysts lined by a single layer of typical hobnail cells with large nuclei and prominent nucleoli. The literature describing biological behavior, immunohistochemical profiles, ultrastructural features and possible differential diagnostic features of TRCC is limited [2][3][4][5][6]. The oncogenesis of this neoplasm is unclear.…”

“…The oncogenesis of this neoplasm is unclear. Pathologic and cytogenetic findings seem to document the close relatedness between TRCC and papillary renal cell carcinomas (PRCC) [6]. The close relationship of TRCC to PRCC is supported not only by high frequency of both tumors coexistence but also by expression of proximal convoluted tubule markers (CD10 and AMACR) and by similar chromosomal abnormalities (chromosome 7 and 17 gains and Y chromosome losses) [1].…”

Tubulocystic Renal Cell Carcinoma: A Rare Renal Tumor

“…Only a few cases so far have been reported of metastases to lymph node, bone, pleura, and liver (11). Its relationship to collecting duct carcinoma is controversial, and recent studies have linked it with papillary RCC.…”

Tubulocystic Carcinoma of the Kidney

“…Th ese tumors rarely progress, recur, or metastasize (6). Rare cases have been reported of metastases to lymph node, bone, pleura, and liver (8). …”

“…Th e fi ndings suggest a strong genetic similarity between TCC and papillary renal cell carcinoma. TCC has been reported with other subtypes of renal cell carcinoma (8). Th ese tumors rarely progress, recur, or metastasize (6).…”