2018
DOI: 10.1039/c7ra09459k
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A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

Abstract: Interests in inorganic applications of triazines is growing. In this report, metal complexes of copper(II), nickel(II), and zinc(II) and a novel class of chelates comprising a triazine ring substituted with a hydrazine group and pyralozone are evaluated using spectrophotometric methods, single crystal X-ray diffractometry, and electrochemistry. Complexes with copper(II) include a single chelate and two chloride atoms to satisfy a trigonal bipryamidal coordination sphere. The nickel(II) and zinc(II) complexes a… Show more

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Cited by 9 publications
(9 citation statements)
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“…The overproduction of ROS is hypothesized to lead to the development of neurodegenerative diseases. A good model for such redox cycling in the brain is the copper/ascorbate redox system (Scheme ). ,, The hydroxyl radicals generated by copper­(II) in the presence of ascorbate and oxygen stoichiometrically convert CCA to the fluorescent hydroxy-CCA species (Figure , inset). , Metal-ion redox chemistry is known to be modulated by coordination to strongly donating small molecules. , Therefore, this model system was used to evaluate the capacity of L4 to halt metal-ion redox cycling under these conditions. The results are compared to L2 to determine if the number of pyridol moieties may play a role in this reactivity as well.…”
Section: Resultsmentioning
confidence: 99%
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“…The overproduction of ROS is hypothesized to lead to the development of neurodegenerative diseases. A good model for such redox cycling in the brain is the copper/ascorbate redox system (Scheme ). ,, The hydroxyl radicals generated by copper­(II) in the presence of ascorbate and oxygen stoichiometrically convert CCA to the fluorescent hydroxy-CCA species (Figure , inset). , Metal-ion redox chemistry is known to be modulated by coordination to strongly donating small molecules. , Therefore, this model system was used to evaluate the capacity of L4 to halt metal-ion redox cycling under these conditions. The results are compared to L2 to determine if the number of pyridol moieties may play a role in this reactivity as well.…”
Section: Resultsmentioning
confidence: 99%
“…91−94 A good model for such redox cycling in the brain is the copper/ascorbate redox system (Scheme 2). 50,95,96 The hydroxyl radicals generated by copper(II) in the presence of ascorbate and oxygen stoichiometrically convert CCA to the fluorescent hydroxy-CCA species (Figure 5, inset). 95,96 Metalion redox chemistry is known to be modulated by coordination to strongly donating small molecules.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“… 2 Other derivatives that possess analgesic, 3 antimicrobial, 4 anti-inflammatory, 5 antioxidant, 6 and antiprion 7 activities have also been reported. Some pyrazolones have been used as fungicides and herbicides for crop protection, as dyes for cotton, wool, and silk, 3 as ligands for synthesis of metal complexes, 8 and as corrosion inhibitors. 9 …”
Section: Introductionmentioning
confidence: 99%
“…Morpholine is then added at room temperature to yield 6 or 7 . Microwave irradiation is employed to facilitate substitution with ethyl glycinate to yield intermediate 8 or 9 . Following saponification of each to 10 or 11 , EDC‐mediated couplings with 1‐amino‐3,3‐diethyoxypropane completes the syntheses.…”
Section: Resultsmentioning
confidence: 99%