A new triazine based π-conjugated mesoporous 2D covalent organic framework: itsin vitroanticancer activities

Abstract

We report a new highly crystalline 2D π-conjugated hexagonal mesoporous covalent organic framework material, TrzCOF, through the solvothermal polycondensation of 1,3,5-tri(4-formylbiphenyl) benzene [Ph7(CHO)3, TFBPB] with 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and it displayed excellent anticancer activity for human colorectal carcinoma HCT-116 cells.

Imine‐Based Covalent Organic Frameworks as Photocatalysts for Metal Free Oxidation Processes under Visible Light Conditions

“…[32] In particular, imine-based COFs have attracted a good deal of attention and became, during the last few years, one of the most popular backbones in this field. [20,[36][37][38][39][40][41][42][43][44][45][46] Therefore, we wondered if imine-based COFs can be used to perform photo-activated synthetic transformations. [33][34][35] Despite the fact that some luminescent behavior has been reported for a simple iminebased layered COF, [36] the use of metal-free simple imine-based COFs, has not been studied in these sulfoxidation reactions.…”

“…[33][34][35] Despite the fact that some luminescent behavior has been reported for a simple iminebased layered COF, [36] the use of metal-free simple imine-based COFs, has not been studied in these sulfoxidation reactions. [20,[36][37][38][39][40][41][42][43][44][45][46] Therefore, we wondered if imine-based COFs can be used to perform photo-activated synthetic transformations. In addition, we studied how their molecular architecture, crystallinity and microstructure can affect the catalytic activity ( Figure 1).…”

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

“…This journal is © The Royal Society of Chemistry 2020 HepG2, and MIA PaCa-2 cells were 9.89 AE 1.16, 11.88 AE 1.82, 14.38 AE 2.01, and 14.30 AE 1.32 mg mL À1 , respectively. similar cytotoxicity 403. The IC 50 values of TrzCOF on B16F10, HepG2, HCT-116, and HEK293 cells were 10.47 AE 2.63, 9.55 AE 2.13, 8.31 AE 1.67, and 14.39 AE 2.25 mg mL À1 , respectively.…”

“…Here, we will introduce the different kinds of methods to make the bread: COF-based oncotherapy examples. Till now, COFs have been used as drug delivery carriers, 221,[396][397][398][399][400][401][402][403] phototherapy reagents, 163,216,223,261,[404][405][406][407][408][409][410] and combination therapy platforms 161,162,220,[411][412][413][414][415] for tumor therapeutics ( Table 5).…”

Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

“…Nanoscale COFs possess not only the good crystallization and porous characteristics of traditional COFs, but also the advantages of good dispersion, small volume, and high bioavailability. At the same time, their unique and tailorable nanostructures and properties make COFs ideal candidates for biomedical applications [27,28], endowing them with high drug loading [29][30][31][32][33], outstanding therapeutic outcome [34][35][36], and sensitive sensing performance [37][38][39]. Although recent years, researchers have seen explosive growth in research on COFs for biomedical applications (Fig.…”