A new titanium based alloy Ti–27Nb–13Zr produced by powder metallurgy with biomimetic coating for use as a biomaterial

Mendes, Marcio W.D.; Ágreda, Carola Gomez; Bressiani, Ana Helena A.; Bressiani, José Carlos

doi:10.1016/j.msec.2016.03.052

Cited by 60 publications

(29 citation statements)

References 30 publications

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“…These values showed that the density of both modified materials was not dramatically increased. The slightly higher value of Ti-Nb was almost negligible compared to other full β-Ti alloys [7]. In the case of Ti-NbNH4Cl, the density value was also very similar to that of Ti, balancing the slightly increase caused by the nitride and niobium presence with the surface porosity as shown in Figure 2b.…”

Section: Accepted Manuscriptmentioning

confidence: 71%

“…However, the introduction of other biocompatible metallic ions such as Nb, Zr or Mo allows the modification of the microstructure decreasing the elastic modulus and thus, improving the integration with surrounding bone and avoiding the death of bone cell because of the stress shielding [5]. Currently, numerous studies are focused on the development of β-Ti alloys in order to match the mechanical requirements and to better distribute the compression force during loading [6], [7], [8], [9], [10]. Recently, the Ti-24Nb-4Zr-8Sn alloy has been reported as a potential candidate in early osseointegration with osteogenic marker expression [11], [12].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Cellular behaviour of bone marrow stromal cells on modified Ti-Nb surfaces

et al. 2018

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The cellular behaviour of bone marrow stromal cells on titanium surfaces modified by niobium diffusion is presented in order to test their osteogenic differentiation response after culturing for 21 days. The surface modification of Ti substrates produced by powder metallurgy was performed through niobium diffusion treatments. Ti-Nb exhibited a β-Ti surface together with a microstructural (β / α+β / α) and compositional (Ti-Nb) gradient which enhances hardness, wear resistance and lowers the elastic modulus making it more similar to the human bone. Furthermore, the Ti-NbNH4Cl by means of the activating agent achieved three times the hardness of Ti together with a porous surface. The in vitro osteogenic differentiation response of bone marrow stromal cells on both Ti-Nb surfaces indicated the positive cell-material interaction. The osteogenic differentiation of cells was successful after 21 days, considering the positive response in terms of increased cell viability, lactate dehydrogenase-(LDH) activity, alkaline phosphatase-(ALP) activity expression (osteogenic marker) and bone-like nodules deposition by ST-2 cells as a bone mineralization cue. Therefore, the positive effect of a low elastic modulus Ti-Nb surface and a porous nitride Ti-NbNH4Cl with suitable wettability and average roughness values on the osteogenic differentiation response of bone marrow stromal cells is demonstrated.

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Section: Accepted Manuscriptmentioning

confidence: 71%

Section: Accepted Manuscriptmentioning

confidence: 99%

Cellular behaviour of bone marrow stromal cells on modified Ti-Nb surfaces

et al. 2018

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“…The techniques associated with biomimetic coatings, which incorporates calcium (Ca), phosphorus (P), and hydroxyapatite, [12,13] have shown greater affinity for osteogenic cells [14][15][16]. Plasma electrolytic oxidation (PEO), also known as anodic spark deposition, is a new implant surface preparation, but it is still in the in vitro testing phase [1,2].…”

Section: Introductionmentioning

confidence: 99%

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

Momesso

Santos

et al. 2020

Materials

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Plasma electrolytic oxidation (PEO) has been a promising surface coating with better mechanical and antimicrobial parameters comparing to conventional treatment surfaces. This study evaluated the peri-implant bone repair using (PEO) surface coatings compared with sandblasted acid (SLA) treatment. For this purpose, 44 Wistar rats were ovariectomized (OVX-22 animals) or underwent simulated surgery (SS-22 animals) and received implants in the tibia with each of the surface coatings. The peri-implant bone subsequently underwent molecular, microstructural, bone turnover, and histometric analysis. Real-time PCR showed a higher expression of osteoprotegerin (OPG), receptor activator of nuclear kappa-B ligand (RANKL), and osteocalcin (OC) proteins in the SLA/OVX and PEO/SS groups (p < 0.05). Computed microtomography, confocal microscopy, and histometry showed similarity between the PEO and SLA surfaces, with a trend toward the superiority of PEO in OVX animals. Thus, PEO surfaces were shown to be promising for enhancing peri-implant bone repair in ovariectomized rats.

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“…Two phases are seen in scanning electron microscope images; one of them is β-phase which is seen as light grey and the other one is α-phase seen as dark grey. The similar phase images (light grey for βphase, and dark grey for α-phase) were determined in the microstructures of bulk TiZrNb alloys by different researchers [1,4,14]. The x-ray diffraction spectrum of the manufactured TiNbZr samples are showed, Figure 2.…”

Section: Resultsmentioning

confidence: 54%

A study on microstructure of porous TiNbZr alloy produced as biomaterial

Kaya¹,

Yakuphanoğlu

2019

Materialwissenschaft Werkst

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In the present study, titanium‐based biomaterial (Ti‐10Nb‐10Zr) with different porosity was fabricated by sintering at different temperatures. The porosity of fabricated samples is close to natural bone; also the compression strengths of the samples are higher than that of natural bone. The phases named α and β are seen in the microstructure of samples fabricated, but α phase partially converts into β phase with increasing sintering temperature. Porosity decreases with increasing sintering temperature, and compressive strength increases with decreasing porosity. Elastic modules of fabricated samples are close to natural bone, so these materials don't cause wear of bone.

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A new titanium based alloy Ti–27Nb–13Zr produced by powder metallurgy with biomimetic coating for use as a biomaterial

Cited by 60 publications

References 30 publications

Cellular behaviour of bone marrow stromal cells on modified Ti-Nb surfaces

Cellular behaviour of bone marrow stromal cells on modified Ti-Nb surfaces

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

A study on microstructure of porous TiNbZr alloy produced as biomaterial

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