A New System, the LipiFlow, for the Treatment of Meibomian Gland Dysfunction

Lane, Stephen S.; DuBiner, Harvey; Epstein, Randy J.; Ernest, Paul; Greiner, Jack V.; Hardten, David R.; Holland, Edward J.; Lemp, Michael A.; McDonald, James E.; Silbert, David I.; Blackie, Caroline A.; Stevens, Christy A.; Bedi, Raman

doi:10.1097/ico.0b013e318239aaea

Cited by 222 publications

(281 citation statements)

References 22 publications

(37 reference statements)

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“…In addition to eyelid masks, promising new eyelid warming technologies include steam [17,19,34,35], thermal [36][37][38][39] and chemically activated disposable sachets [40]. Aside from the effect on the meibum, warm compresses can also transiently degrade vision from the light pressure of the compress [41].…”

Section: Discussionmentioning

confidence: 99%

Ex vivo heat retention of different eyelid warming masks

Lacroix

Léger

Bitton

2015

Contact Lens and Anterior Eye

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Section: Discussionmentioning

confidence: 99%

Ex vivo heat retention of different eyelid warming masks

Lacroix

Léger

Bitton

2015

Contact Lens and Anterior Eye

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“…A device recently approved by the FDA, continuous controlled thermal compression (Lipiflow SystemÔ), liquefies the meibomian gland secretion and then expresses the material. 99,100 Although this treatment has been noted (observational studies only) to have an extended duration of effect in some cases, further evaluation and controlled comparative clinical trials will be needed to validate the efficacy and cost-effectiveness for such therapy. 101 When closure or partial closure of the eyelid is indicated for short periods of time, botulinum toxin injection has been used.…”

Section: H Management Of Eyelidsmentioning

confidence: 96%

Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease

et al. 2015

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“…The original prospective open-label randomized study, funded by the manufacturer, TearScience Ò , compared a 12-minute LipiFlow Ò treatment (in 69 patients) and control treatment (in 70 patients) with a commercially available iHeat warm compress system for 5 min. The authors concluded that the LipiFlow Ò treatment group had a statistically significantly improved MG secretion quality and tear break-up times from baseline to both 2 and 4 weeks [18]. One of the original authors later published a study following 18 patients over 12 months, which suggested that a single 12-minute LipiFlow Ò treatment offered an effective treatment for evaporative dry eye and MGD, even after 1 year [19].…”

Section: Manual and Mechanical Techniquesmentioning

confidence: 95%

Current and Emerging Therapeutic Strategies for the Treatment of Meibomian Gland Dysfunction (MGD)

Thode

Latkany

2015

Drugs

117

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Meibomian gland (MG) dysfunction (MGD) is a multifactorial, chronic condition of the eyelids, leading to eye irritation, inflammation and ocular surface disease. Initial conservative therapy often includes a combination of warm compresses in addition to baby shampoo or eyelid wipes. The practice of lid hygiene dates back to the 1950s, when selenium sulfide-based shampoo was first used to treat seborrhoeic dermatitis of the eyelids. Today, tear-free baby shampoo has replaced dandruff shampoo for MGD treatment and offers symptom relief in selected patients. However, many will not achieve significant improvement on this therapy alone; some may even develop an allergy to the added dyes and fragrances in these products. Other manual and mechanical techniques to treat MGD include MG expression and massage, MG probing and LipiFlow(®). While potentially effective in patients with moderate MGD, these procedures are more invasive and may be cost prohibitive. Pharmacological treatments are another course of action. Supplements rich in omega-3 fatty acids have been shown to improve both MGD and dry eye symptoms. Tea tree oil, specifically the terpenin-4-ol component, is especially effective in treating MGD associated with Demodex mites. Topical antibiotics, such as azithromycin, or systemic antibiotics, such as doxycycline or azithromycin, can improve MGD symptoms both by altering the ocular flora and through anti-inflammatory mechanisms. Addressing and treating concurrent ocular allergy is integral to symptom management. Topical N-acetylcysteine and topical cyclosporine can both be effective therapeutic adjuncts in patients with concurrent dry eye. A short course of topical steroid may be used in some severe cases, with monitoring for steroid-induced glaucoma and cataracts. While the standard method to treat MGD is simply warm compresses and baby shampoo, a more tailored approach to address the multiple aetiologies of the disease is suggested.

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A New System, the LipiFlow, for the Treatment of Meibomian Gland Dysfunction

Abstract: The LipiFlow System was significantly more effective than iHeat WC. These results support its safety and effectiveness in the treatment of MGD and dry eye symptoms.

Cited by 222 publications

References 22 publications

Ex vivo heat retention of different eyelid warming masks

Ex vivo heat retention of different eyelid warming masks

Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease

Current and Emerging Therapeutic Strategies for the Treatment of Meibomian Gland Dysfunction (MGD)

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