Ex vivo heat retention of different eyelid warming masks

Lacroix, Zoé; Léger, Stéphanie; Bitton, Etty

doi:10.1016/j.clae.2015.01.005

Cited by 25 publications

(34 citation statements)

References 27 publications

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“…Our participant cohort had normal baseline tear osmolarity (less than 308 mOsmol/L) 29.30 possibly because they were using and continued to use, warm compresses and topical lubricants at baseline and during the study. These conventional treatments have been demonstrated to lower tear osmolarity …”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the use of a wet warm face cloth versus an external lid warming device that may more consistently regulate the elevation of temperature to the external lid is a further limitation. Similarly, we acknowledge the lack of regulation in technique, pressure and duration of the home‐based ‘lid massage’ component of treatment compared with the use of an automated thermodynamic clinic‐based treatment .…”

Section: Discussionmentioning

confidence: 99%

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Randomised controlled trial of topical antibacterial Manuka (Leptospermum species) honey for evaporative dry eye due to meibomian gland dysfunction

Albietz

Schmid

2017

Clinical and Experimental Optometry

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Background:The aim was to evaluate the efficacy of standardised Manuka (Leptospermum species) antibacterial honey as adjunctive twice daily treatment to conventional therapy (warm compresses, lid massage and preservative-free lubricant), in participants with evaporative dry eye due to moderate to advanced meibomian gland dysfunction. Methods:This prospective, open-label study involved 114 participants. After two weeks of conventional therapy participants were randomised to one of three treatment groups: Optimel Antibacterial Manuka Eye Gel (98 per cent Leptospermum species honey) plus conventional therapy (n = 37), Optimel Manuka plus Lubricant Eye Drops (16 per cent Leptospermum species honey) plus conventional therapy (n = 37) and a control (conventional therapy) (n = 40). Clinical evaluations performed at baseline and Week 8 included: symptom scores (Ocular Surface Disease Index, Ocular Comfort Index), daily lubricant use, tear assessments (break-up time, secretion, osmolarity and InflammaDry), corneal sensation, ocular surface staining, meibomian gland secretion quality and expressibility, bulbar conjunctival, limbal and lid marginal redness and eyelid marginal bacterial cultures and colony counts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Randomised controlled trial of topical antibacterial Manuka (Leptospermum species) honey for evaporative dry eye due to meibomian gland dysfunction

Albietz

Schmid

2017

Clinical and Experimental Optometry

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“…4 Elevated eyelid temperature delivers more meibomian oil to the eyelid. 5 Numerous devices have been developed to warm the eyelid [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] and the warming relieves dry eye symptoms, 13,[15][16][17][18]21 improves meibum score, 11,15,16 increases tear breakup time, 11,[15][16][17] and tear lipid layer thickness 14 and ameliorates dry eye related morphological changes in the meibomian gland. 11,[16][17][18] One study found that heating did not improve their breakup time or lipid layer thickness.…”

Section: Introductionmentioning

confidence: 99%

The optimum temperature for the heat therapy for meibomian gland dysfunction

Borchman

2019

The Ocular Surface

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Purpose-Numerous devices have been developed to warm the eyelid as a therapy for Meibomian gland dysfunction. The optimum temperature for such therapy was determined. Methods-Meibum lipid disorder versus temperature was calculated from previously published phase transition parameters measured using infrared spectroscopy. Phase transitions parameters were calculated from meibum obtained from donors with Meibomian gland dysfunction (M MGD), donors who were susceptible to dry eye after hematopoietic stem cell transplantations (M HSCT) and meibum from donors without dry eye (Mn). Results-Heating Mn to 40 °C increases the lipid disorder by 20.4% to 90 %. Heating the meibum another 4 degrees increases the disorder to 95%. M MGD is 73.2 % disordered with no heating. Heating M MGD to 41.5 °C increases the disorder by 26.8 % to 90 % disordered. Heating M MGD another 5.1 °C increases the disorder to 95%. As meibum from donors who had hematopoietic stem cell transplantations, M HSCT , is much more ordered, 56.9 % disordered compared with M n and M MGD , a higher temperature above safety limits, 52 and 59 °C is need to disorder M HSCT to 90 and 95% disorder. Conclusions-Heating the eye lid above the phase transition temperature of meibum increases the disorder of meibum lipid which could ameliorate dry eye symptoms. The optimum temperature for disordering Mn and M MGD to 90% maximum disorder is 40 and 41.5 °C, respectively. Safety issues and discomfort should be considered in obtaining an optimal level of disorder, especially for severe cases of dry eye.

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“…Conventional advice to apply a warm, moist cloth over the eyelids has lost favour due to the potential for fast cooling of the cloth and concerns relating to contamination and inconvenience. Controlled and relatively more standardised methods for periocular heating to manage MGD include hydrating bead pouches and microwave‐heated seed bags; these appliances are applied to the closed eyelids for five to 10 minutes . Various products are available, including the MGDRx EyeBag (Figure ), a Food and Drug Administration Class 1 medical device that can improve both patient signs and symptoms of MGD, and has been shown to possess a heating profile superior to that of a portable heating mask that utilises chemical exothermic reaction as the source of heat …”

Section: Optimising Tear Film and Ocular Surface Health For Contact Lmentioning

confidence: 99%

Tear film evaluation and management in soft contact lens wear: a systematic approach

Downie

Craig

2017

Clinical and Experimental Optometry

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The human tear film is a highly ordered structure consisting of a thin layer of lipid on the surface and a thicker aqueous-mucin phase, which increases in mucin concentration toward the corneal epithelial cell layer. The health of the tear film and ocular surface influences the likelihood of being able to achieve successful contact lens wear. Contact lens discomfort and dryness are the most frequent reasons why contact lens wearers experience reduced wearing times, which can eventually lead to contact lens discontinuation. Comprehensive clinical assessment of tear film integrity and ocular surface health is therefore essential prior to commencing contact lens wear, to enable the ocular surface environment to be optimised to support lens wear. These parameters should also be evaluated over the course of contact lens wear, in order to identify any aspects requiring clinical management and ensure maintenance of optimal lens-wearing conditions. This review summarises current knowledge relating to the effects of soft contact lens wear on the tear film and ocular surface. It also provides a systematic approach to evaluating tear film and ocular surface integrity, in order to guide the clinical management of tear film anomalies with respect to contact lens wear.Key words: conjunctiva, contact lenses, cornea, dry eye, tearsThe tear film is a complex, precisely ordered fluid structure comprising a thin outer layer of lipid and a thicker underlying aqueous-mucin phase, with increasing mucin concentration toward the corneal epithelial cell layer. A thin layer of membrane-bound mucin, glycocalyx, imparts hydrophilicity to the hydrophobic corneal surface.1 In excess of 1,000 proteins or fractions of proteins have been identified within the human tear film.2,3 The tear fluid also contains a variety of regulated inflammatory mediators, including by-products of arachidonic acid metabolism, the complement cascade, cytokines and components derived from the ocular microbiome. 3,4The integrity of the tear film can strongly influence the likelihood of achieving successful contact lens wear. Contact lens discomfort and dryness are the most frequent reasons why contact lens wearers experience reduced wearing times, which can eventually lead to contact lens discontinuation. 5 Comprehensive clinical assessment of tear film quality and quantity, and ocular surface health are therefore essential both prior to commencing contact lens wear, to enable the ocular surface environment to be optimised to support lens wear, and over the course of lens wear, to identify any aspects requiring clinical attention to maintain optimal lens-wearing conditions. This review summarises current knowledge relating to the effects of soft contact lens wear on tear film composition, and outlines an approach to evaluating tear film and ocular surface integrity, to guide the clinical management of tear film anomalies with respect to contact lens wear. ASSESSING THE TEAR FILM AND OCULAR SURFACE IN CONTACT LENS WEAR: A SYSTEMATIC APPROACHUsing techniques such as in...

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Ex vivo heat retention of different eyelid warming masks

Cited by 25 publications

References 27 publications

Randomised controlled trial of topical antibacterial Manuka (Leptospermum species) honey for evaporative dry eye due to meibomian gland dysfunction

Randomised controlled trial of topical antibacterial Manuka (Leptospermum species) honey for evaporative dry eye due to meibomian gland dysfunction

The optimum temperature for the heat therapy for meibomian gland dysfunction

Tear film evaluation and management in soft contact lens wear: a systematic approach

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