A new synthetic resorcinolic lipid 3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one: Evaluation of toxicology and ability to potentiate the mutagenic and apoptotic effects of cyclophosphamide

Navarro, Stephanie Dynczuki; Beatriz, Adilson; Meza, Alisson; Pesarini, João Renato; Gomes, Roberto da Silva; Karaziack, Caroline Bilhar; Cunha-Laura, Andréa Luiza; Monreal, Antônio Carlos Duenhas; Romão, Wanderson; Júnior, Valdemar Lacerda; Mauro, Mariana de Oliveira; Oliveira, Rodrigo Juliano

doi:10.1016/j.ejmech.2014.01.057

Cited by 35 publications

(88 citation statements)

References 66 publications

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“…In addition, it can prevent and repair damage done to DNA (Stepanenko et al, 2004). A recent study indicated that a new resorcinolic lipid, 3-heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one (AMS35AA) alone produced neither genotoxic nor mutagenic effects in mice (Navarro et al, 2014). Otherwise, both cardanol and cardol exhibited antiproliferative properties with LC 50 ranging from 41.3 to 52.4 mg/ml and 43.8 to 53.5 µg/ml in cancer cell lines (Teerasripreecha et al, 2012).…”

Section: A Occidentale and Its Biological Rolesmentioning

confidence: 99%

Pharmacological properties of cashew (Anacardium occidentale)

Leite¹,

Islam²,

Junior³

et al. 2016

Afr. J. Biotechnol.

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Anacardium occidentale L. is a tree native to Brazil, which is rich in phenolic lipids. Nowadays, the cashew bark (Cashew Nut Shell Liquid) has received great attention in the pharmaceutical industry, due to its economy, abundance and important chemical compounds. Net of cashew nut shell is classified according to the method of production of: (1) net of the shell of natural cashew nut (60-65% anacardic acid; 15-20% cardol and 10% of cardanol) and (2) liquid from the technical cashew nut shell (60-65% of cardanol, 15-20% cardol and 10% of polymeric material). This work aims to report the pharmacological properties of liquids from cashew nut shells. Results suggest that both liquids have antifungal, antibacterial, antiparasitic, anti-tumor, antiulcerogenic, molluscicides, antimutagenic and antioxidant activities. Natural cashew nut liquid is non-genotoxic, whereas technical liquid is genotoxic in prokaryotes and eukaryotes, although there is no evidence of their mutagenic effects on eukaryotic cells. In conclusion, the excellent antioxidant and non-mutagenic activities of cashew nut shell liquid (CNSL) provide opportunities for CNSL in the cosmetic and/or pharmaceutical industries, but continuous study is needed to allow safe and efficacious preparations.

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Section: A Occidentale and Its Biological Rolesmentioning

confidence: 99%

Pharmacological properties of cashew (Anacardium occidentale)

Leite¹,

Islam²,

Junior³

et al. 2016

Afr. J. Biotechnol.

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“…A total of 100 cells per animal were analyzed. Apoptotic cells were identified by analyzing the resultant DNA fragmentation patterns (Navarro et al, 2014).…”

Section: Apoptosis Assaymentioning

confidence: 99%

“…The slides were examined using light-field microscopy at a 1000X magnification. A total of 100 cells were analyzed per animal and categorized as lymphocytes, neutrophils, monocytes, eosinophils, and basophils (Navarro et al, 2014). …”

Section: Differential Blood Countmentioning

confidence: 99%

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Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

Magosso¹,

Carvalho

Shneider³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Acrocomia aculeata is a plant rich in antioxidant compounds. Studies suggest that this plant has anti-inflammatory, antidiabetic, and diuretic potential. We assessed the antigenotoxic, antimutagenic, immunomodulation, and apoptotic potentials of A. aculeata alone and in combination with an antitumor agent, cyclophosphamide. Swiss male mice (N = 140) were used. The animals were divided into 14 experimental groups as follows: a negative group, a positive group (100 mg/kg cyclophosphamide), groups that only received the oil extracted from the almond (AO) and from the pulp (PO) of A. aculeata at doses of 3, 15, and 30 mg/kg, and the associated treatment groups (oils combined with cyclophosphamide) involving pretreatment, simultaneous, and post-treatment protocols. Data suggest that both oils were chemopreventive at all doses, based on the tested protocols. The highest damage reduction percentages, observed for AO and PO were 88.19 and 90.03%, respectively, for the comet assay and 69.73 and 70.93%, respectively, for the micronucleus assay. Both AO and PO demonstrated immunomodulatory activity. The oils reduced the capacity of cyclophosphamide to trigger apoptosis in the liver, spleen, and kidney cells. These results suggest that A. aculeate AO and PO can be classified as a functional food and also enrich other functional foods and nutraceuticals with chemopreventive features. However, they are not appropriate sources for chemotherapeutic adjuvants, in particular for those used in combination with cyclophosphamide.

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“…The slides were fixed in Carnoy's solution for 5 min and then subjected to a gradient of decreasing concentrations of ethanol (95-25%), washed with McIlvaine's buffer for 5 min, stained with 0.01% acridine orange for 5 min, and then washed again with buffer. A total of 100 cells per animal were assessed for apoptosis based on DNA fragmentation patterns described by Navarro et al (2014).…”

Section: Cell Death By Apoptosismentioning

confidence: 99%