A New Synthesis of Benzo[c]fluorene-Structures

Fies, M.; Strobel, Michael; Friedrich, K.

doi:10.1002/prac.199633801109

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1996

2022

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“…[9] Despite the high interest in their scaffolds, DHBFs are less studied than THBFs, possibly due to their assumed lower chemical stability. [10] Nevertheless, some synthetic strategies have been developed to conceive these types of heterocyclic compounds during the last decades.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Dihydro‐5H‐Benzo[c]‐Fluorenes, Dihydroindeno[c]‐Chromenes and Thiochromenes via Intramolecular Cyclization and their Effect on Human Leukemia Cells

et al. 2022

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In this work, we describe the construction of a series of 6,7-dihydro-5Hbenzo[c]fluorenes. Their synthesis is based on an intramolecular-cyclization of tricyclic substrates, which has an alcohol functional group in acidic conditions at ambient temperature. Certain reaction optimization conditions reveal that triflic acid was the most convenient reagent for this transformation, affording a broad range of fluorene derivatives in a 37 to 93% yield. We illustrate the robustness of this methodology through a gram-scale synthesis, and the preparation of dihydroindeno[c]-chromenes thiochromenes, and azulenes derivatives.

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Section: Introductionmentioning

confidence: 99%