2013
DOI: 10.1590/0074-0276130303
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A new survey of the serology of human Trypanosoma cruziinfection in the Rio Negro microregion, Brazilian Amazon: a critical analysis

Abstract: The serology of human Trypanosoma cruzi infection in the Rio Negro microregion is very complex because of the large numbers of false-positive cases that result from low antibody titres and cross-reactions with other infections. In the present study, we collected 4,880 blood samples on filter paper; of these, indirect immunofluorescence (IIF) was strongly reactive in 221 (4.5%), which were considered to be positive (IIF strongly reactive; high intensity of fluorescence) and weakly reactive in 302 (6.2%), which … Show more

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Cited by 8 publications
(6 citation statements)
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“…These studies showed that the prevalence of chagasic infection ranged from 1-13%, with low morbidity in the chronic phase. In Amazonas, studies have reported a prevalence varying from 3.5 to 1.4%, depending on the region (11) (39) (40) . Coura et al (40) reported prevalences in the urban area of Barcelos, State of Amazonas; upon encountering a markedly low prevalence, they recommended that studies conducted in Amazonia should use at least two tests [indirect immunofl uorescence antibody test) (IFI) + enzyme-linked immunosorbent assay(ELISA)] and be verifi ed by Western blot (17) (27) (38) (40) .…”
Section: Chagas Disease In the State Of Amazonasmentioning
confidence: 99%
“…These studies showed that the prevalence of chagasic infection ranged from 1-13%, with low morbidity in the chronic phase. In Amazonas, studies have reported a prevalence varying from 3.5 to 1.4%, depending on the region (11) (39) (40) . Coura et al (40) reported prevalences in the urban area of Barcelos, State of Amazonas; upon encountering a markedly low prevalence, they recommended that studies conducted in Amazonia should use at least two tests [indirect immunofl uorescence antibody test) (IFI) + enzyme-linked immunosorbent assay(ELISA)] and be verifi ed by Western blot (17) (27) (38) (40) .…”
Section: Chagas Disease In the State Of Amazonasmentioning
confidence: 99%
“…Thus, the patterns of serological diagnoses differ from those used in the classical endemic regions for Chagas disease in Brazil. Therefore, the recommendation is that serological evaluations of T. cruzi infection in the Amazon Region should be confirmed by at least two techniques with different principles, such as IIF on the serum, ELISAs and, when possible, Western blots ( Coura et al 2013 ).…”
Section: Discussionmentioning
confidence: 99%
“…More recently (2010/2011), a screening seroepidemiological study using IIF on blood collected in filter paper was performed with 4,480 residents in the study area. In this study, 221 were strongly reactive and were considered positive, while 302 were weakly reactive and were considered doubtful ( Coura et al 2013 ). Ferraroni et al (1977) were the first to serologically confirm chronic cases of Chagas infection among autochthonous patients in the municipality of Barcelos in the microregion of the Negro River, AM.…”
mentioning
confidence: 92%
“…AMCHA - Chagas disease in the Amazon Region can be characterised by the following patterns: (i) an enzooty exchanged by wild vectors, which may be transmitted to humans when either they invade the wild ecotope or when the vectors and wild animals, especially marsupials, invade human homes, a situation that characterises an anthropozoonosis ( Coura et al 1993 , 2002 , Coura & Junqueira 2012 ), (ii) an endemic disease through oral transmission of T. cruzi by means of consumption of juices and other uncooked foods and foods contaminated by the faeces and urine of wild triatomines or odoriferous secretion of marsupials, thereby causing acute outbreaks of the disease ( Valente et al 1999 , 2009 , Pinto et al 2003 , 2008 , Coura 2006 , Coura & Junqueira 2012 , Souza-Lima et al 2013 ) and (iii) a professional disease among people who work in plant extraction, especially piassava gatherers, who suffer attacks by wild triatomines ( Rhodnius brethesi ) ( Brum-Soares et al 2010 , Coura & Junqueira 2012 , Coura et al 2013 ). The AMCHA began officially in 2004, at a meeting held in Manaus, Brazil, after a preparatory meeting held in Palmari, on the border of Brazil and Colombia in 2002, promoted by European Community Latin America Triatominae ( Guhl & Schofield 2004 ).…”
mentioning
confidence: 99%