A new sulfonylated flavonoid and other bioactive compounds isolated from the aerial parts of <i>Cotula anthemoides</i> L.

Tadrent, Wafa; Magid, Abdulmagid Alabdul; Kabouche, Ahmed; Harakat, Dominique; Voutquenne-Nazabadioko, Laurence; Kabouche, Zahia

doi:10.1080/14786419.2016.1261342

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…Tyrosinase activity inhibition was determined spectrophotometrically according to the method previously described by Tadrent et al [16]. Kojic acid was used as positive control agent.…”

Section: Tyrosinase Enzyme Assaymentioning

confidence: 99%

Antibacterial, antioxidant and cytotoxic activities of triterpenes and flavonoids from the aerial parts of Salvia barrelieri Etl.

Lehbili

Magid

Kabouche

et al. 2017

Natural Product Research

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From the aerial parts of Salvia barrelieri Etl. (Lamiaceae), 12 compounds including a new triterpene, 3β-acetoxy-olean-18-ene-2α-ol, were isolated. Their structures were established by the combination analyses of spectroscopy including 1D-, 2D-NMR and HRESIMS and in comparison with the reported data in the literature. The antibacterial activity of these compounds was evaluated by bioautography on Staphylococcus aureus followed by the determination of MIC values by serial dilution technique against five bacteria. Three compounds were active against Enterococcus faecalis, S. aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa (MIC 15.1 to 125 μg/mL). Two compounds showed moderate DPPH radical scavenging activity (IC 79.1 and 21.2 μg/mL). These compounds did not show significant tyrosinase inhibitory activities (IC 1.5 mg/mL). Their cytotoxic activity was evaluated against promyelocytic leukaemia (HL60), human erythromyeloblastoid leukaemia (K562) and fibrosarcoma (HT1080) cell lines and four compounds exhibited a moderate cytotoxic activity (IC 28.75 to 85.0 μM).

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“…Tyrosinase activity inhibition was determined spectrophotometrically according to the method previously described by Tadrent et al [16]. Kojic acid was used as positive control agent.…”

Section: Tyrosinase Enzyme Assaymentioning

confidence: 99%

Antibacterial, antioxidant and cytotoxic activities of triterpenes and flavonoids from the aerial parts of Salvia barrelieri Etl.

Lehbili

Magid

Kabouche

et al. 2017

Natural Product Research

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“…The genus Cotula is of the Asteraceae family and consists of about 80 species, mostly endemic to South Africa [ 11 ]. Cotula species are traditionally used as anti-inflammatory, antipyretic, antiprotozoal, analgesic, bacteriostatic, or antiseptic agents and in the treatment of digestive disorders [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anti-Inflammatory Activity of Cotula anthemoides Essential Oil and In Silico Molecular Docking of Its Bioactives

et al. 2022

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The genus Cotula (Asteraceae) comprises about 80 species, amongst them Cotula anthemoides L. It is a wild plant growing in Egypt that possesses many traditional uses as a headache, colic, and chest cold remedy. In our study, the chemical composition of C. anthemoides essential oils was analyzed using GC-MS spectroscopy. Sixteen components of leave and stem oils and thirteen components of flower oils were characterized. The main components in both essential oil parts were camphor (88.79% and 86.45%) and trans-thujone (5.14% and 10.40%) in the leaves and stems and the flowers, respectively. The anti-inflammatory activity of the oils in lipopolysaccharide-stimulated RAW 264.7 macrophage cells was evaluated. The flower oil showed its predominant effect in the amelioration of proinflammatory cytokines and tumor necrosis factor-α, as well as cyclooxygenase-2. The bornyl acetate showed the highest affinity for the cyclooxygenase-2 receptor, while compound cis-p-menth-2-ene-1-ol had the best affinity for the tumor necrosis factor receptor, according to the results of molecular docking. In addition, the molecule cis-β-farnesene showed promising dual affinity for both studied receptors. Our findings show that essential oils from C. anthemoides have anti-inflammatory properties through their control over the generation of inflammatory mediators. These findings suggest that C. anthemoides essential oils could lead to the discovery of novel sources of anti-inflammatory treatments.

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Chemical constituents of the roots of Scorzonera divaricata and their chemotaxonomic significance

Meng

Yang

Gong

et al. 2020

Biochemical Systematics and Ecology

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A new sulfonylated flavonoid and other bioactive compounds isolated from the aerial parts of Cotula anthemoides L.

Cited by 9 publications

References 35 publications

Antibacterial, antioxidant and cytotoxic activities of triterpenes and flavonoids from the aerial parts of Salvia barrelieri Etl.

Antibacterial, antioxidant and cytotoxic activities of triterpenes and flavonoids from the aerial parts of Salvia barrelieri Etl.

In Vitro Anti-Inflammatory Activity of Cotula anthemoides Essential Oil and In Silico Molecular Docking of Its Bioactives

Chemical constituents of the roots of Scorzonera divaricata and their chemotaxonomic significance

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