A new strategy for highly sensitive immunoassay based on single-particle mode detection by inductively coupled plasma mass spectrometry

Hu, Shenghong; Liu, Rui; Zhang, Sichun; Huang, Zhihua; Xing, Zhi; Zhang, Xinrong

doi:10.1016/j.jasms.2009.02.005

Cited by 91 publications

(77 citation statements)

References 38 publications

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“…(b) Silver nanoparticle size distributions before and after wash cycle in all-purpose detergent. Adapted from Mitrano et al [134] Copyright (2015) American Chemical Society potential to be used in highly selective immunoassay, as NPs can be functionalized with a number of different biomarkers, and the sensitivity of spICP-MS can be exploited to detect these bioconjugated particles [138][139][140].…”

Section: Biological Uptake/medical Applicationsmentioning

confidence: 99%

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

et al. 2016

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From its early beginnings in characterizing aerosol particles to its recent applications for investigating natural waters and waste streams, single particle inductively coupled plasma-mass spectrometry (spICP-MS) has proven to be a powerful technique for the detection and characterization of aqueous dispersions of metal-containing nanomaterials. Combining the high-throughput of an ensemble technique with the specificity of a single particle counting technique and the elemental specificity of ICP-MS, spICP-MS is capable of rapidly providing researchers with information pertaining to size, size distribution, particle number concentration, and major elemental composition with minimal sample perturbation. Recently, advances in data acquisition, signal processing, and the implementation of alternative mass analyzers (e.g., time-of-flight) has resulted in a wider breadth of particle analyses and made significant progress toward overcoming many of the challenges in the quantitative analysis of nanoparticles. This review provides an overview of spICP-MS development from a niche technique to application for routine analysis, a discussion of the key issues for quantitative analysis, and examples of its further advancement for analysis of increasingly complex environmental and biological samples. Graphical Abstract Single particle ICP-MS workflow for the analysis of suspended nanoparticles.

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Section: Biological Uptake/medical Applicationsmentioning

confidence: 99%

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

et al. 2016

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“…Au NPs have been applied in ICPMS-based immunoassay since the pioneer works reported by Zhang et al [91] and later by Tanner goupe [92]. Those methods could achieve the detection limits of enzyme-linked immunosorbent assay (ELISA), and their sensitivity can be further enhanced by single particle mode detection [93,94]. Another approach often used to enhance sensitivity is signal amplification.…”

Section: Labeling and Amplificationmentioning

confidence: 99%

Exploration of nano-surface chemistry for spectral analysis

Liu

Lü

et al. 2013

Chin. Sci. Bull.

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The applications of nano-surface chemistry in the field of spectral analysis have attracted growing interest in recent years. In this article, we reviewed the applications of nanomaterials-based chemical reactions for spectral analysis, including the development in plasma-catalysis, surface-enhanced spectroscopy, separation and preconcentration, chemical vapor generation, labeling and signal amplification. Introduction of nano-surface chemistry to spectral analysis not only improves the sensitivity and selectivity, broadens the application range of spectral analysis, but also affords analytical community special characterization tools.surface chemistry, nanomaterial, plasma, separation, chemical vapor generation, opticle gas sensors, atomic spectrometry Citation:Li C H, Liu R, Lü Y, et al. Exploration of nano-surface chemistry for spectral analysis.

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“…A highly sensitive piezoelectric immunosensor has been proposed using AuNPs tag and applied to detect aflatoxin B 1 in contaminated milk [63], in which the indirect competitive immunoassay strategy is applied for the detection of the target using AuNPs as a "weight tag" to the secondary antibodies for amplifying the response. A highly sensitive immunoassay is proposed based on time-resolved inductively coupled plasma mass spectrometry with AuNPs (15 nm) as tags to antibodies [64]. The similar mass spectrometric immunoassay strategy has also been proposed to detect human IgG in immunomicroarray mode with a detection limit of 0.012 ng/mL [65].…”

Section: Nanomaterials For Immunosensing Of Proteinsmentioning

confidence: 99%

Sensitive biosensing strategy based on functional nanomaterials

2011

Sci. China Chem.

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The first decade of the 21st century has been labeled as "the sensing decade". The functional nanomaterials offer excellent platforms for fabrication of sensitive biosensing devices, including optical and electronic biosensors. A lot of works have focused on the biofunctionalization of different nanomaterials, such as metal nanoparticles, semiconductor nanoparticles and carbon nanostructures, by physical adsorption, electrostatic binding, specific recognition or covalent coupling. These biofunctionalized nanomaterials can be used as catalysts, electronic conductors, optical emitters, carriers or tracers to obtain the amplified detection signal and the stabilized recognition probes or biosensing interface. The designed signal amplification strategies have greatly promoted the development of stable, specific, selective and sensitive biosensors in different fields. This review introduces some novel principles and detection strategies in the area of biosensing, based on functional nanomaterials. The general methods for biofunctionalization of nanomaterials with biomolecules and their biosensing application in immunoassay of protein, DNA detection, carbohydrate analysis and cytosensing are also described.

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A new strategy for highly sensitive immunoassay based on single-particle mode detection by inductively coupled plasma mass spectrometry

Cited by 91 publications

References 38 publications

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

Exploration of nano-surface chemistry for spectral analysis

Sensitive biosensing strategy based on functional nanomaterials

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