A new steroid glycoside and furochromones from <b> <i>Cyperus rotundus</i> </b> L.

Sayed, Hanaa M.; Mohamed, Marghny H.; Farag, Sherif; Mohamed, Gamal A.; Proksch, Peter

doi:10.1080/14786410701193056

Cited by 68 publications

(45 citation statements)

References 38 publications

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“…2 Furthermore, the plant possesses different biological activities such as antioxidant, [3][4][5] cytotoxic, 3,5 anti-allergic, 6,7 antipyretic, anti-inflammatory, antiemetic, hypotensive, 8 anticonvulsant, 9 anti-malarial, antimicrobial, 10,11 anti-diarrhoeal, 12 anti-diabetic, 5,13,14 hepatoprotective, 14,15 and insecticide. 16,17 The previous phytochemical studies of C. rotundus L. led to the isolation of sesquiterpenes, 13,[18][19][20][21][22][23] flavonoids, 3,5,8,24,25 phenylpropanoids, 5,26,27 phenolic acids, 5,26 alkaloids, 28 and saponins. 29 In 2013 Zhou and Zhang reported the isolation of iridoid glycosides from C. rotundus rhizomes.…”

Section: Introductionmentioning

confidence: 99%

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Mohamed

2015

Bulletin of Faculty of Pharmacy, Cairo University

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On continuation of the phytochemical investigation of the MeOH extract of Cyperus rotundus L. Rhizomes, four compounds namely, methyl 3,4-dihydroxy benzoate (1), ipolamiide (2), 6b-hydroxyipolamiide (3), and rutin (4) were isolated. Their structures were established on the basis of 1D and 2D NMR spectroscopic analyses as well as ESIMS spectral data. Compounds 2 and 3 are reported here for the first time from the genus Cyperus and 1 for the first time from the plant. Co-treatment of CCl 4 hepatic injured rats with the total MeOH extract (TME) and EtOAc fraction significantly restored the hepatic marker enzymes and total bilirubin to near-normal values compared to silymarin (reference drug).ª 2015 Production and hosting by Elsevier B.V. on behalf

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Section: Introductionmentioning

confidence: 99%

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Mohamed

2015

Bulletin of Faculty of Pharmacy, Cairo University

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“…The strong antioxidant properties of C. rotundus have been shown to be due to its polyphenol, terpene and essential oil contents (Kilani et al, 2008;Priya-Rani & Padmakumari, 2012;. It has also been reported that C. rotundus showed cytotoxic and apoptosis-inducing effects against various tumor cells (Kilani et al, 2008;Kilani-Jaziri et al, 2009;Sayed et al, 2007). Jin et al (2011) reported that sesquiterpenes prepared from a 70% ethanol extract of the rhizomes of C. rotundus exerted significant anti-allergic activity in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Tran

Nguyen

et al. 2013

Pharmaceutical Biology

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Context: A methanol extract of Cyperus rotundus L. (Cyperaceae) rhizomes showed inhibitory activity against a-glucosidase and a-amylase, two enzymes involve in carbohydrate digestion. Objective: Identification of compounds from C. rotundus rhizomes responsible for the inhibition of a-glucosidase and a-amylase. Materials and methods: Compounds were identified by a phytochemical investigation using combined chromatographic and spectroscopic methods. a-glucosidase and a-amylase inhibitory activities were evaluated by in vitro enzyme inhibition assays.0 ,5,6,7,8-hexahydroxyflavane (1), together with three known stilbene dimers cassigarol E (2), scirpusin A (3) and B (4) were isolated. Compound 2 inhibited both a-glucosidase and a-amylase activities while the flavane 1 only showed effect on a-amylase, and compounds 3 and 4 were active on a-glucosidase. All four compounds showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Discussion: The inhibitory activities against a-amylase and a-glucosidase of the C. rotundus rhizomes were reported for the first time. Stilbene dimers are considered as potent inhibitors of a-glucosidase and promising antihyperglycemic agents. Conclusion: The isolated compounds may contribute to the antidiabetic property of C. rotundus.

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“…A creeping herb rooting at the joints with smooth upward stem. Previous phytochemical studies on C. rotundus Corresponding Author: *sadeekaLJ@gmail.com revealed the presence of alkaloids, flavonoids, tannins, starch, glycosides and furochromones, and many novel sesquiterpenoids (Xu et al, (2008); Sayed et al, (2007) and Jeong et al, (2000)). …”

Section: Introductionmentioning

confidence: 99%

ALLELOPATHIC EFFECTS OF Cyperus rotundus L. AND Cynodan dactylon L. ON GERMINATION AND GROWTH RESPONSES OF LETTUCE (Lactuca sativa)

Jayasinghe¹,

Weerawansha²

2016

International Conference on Fisheries and Aquaculture

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This study was conducted to investigate the allopathic effects of Cyperus rotundus and Cynodan dactylon (L.) extracts on seed germination and seedling growth characters of lettuce (Lactuca sativa). Four concentrations (5, 10, 15 and 20 %) of whole plant aqueous extracts of both weeds were tested for assessing their allelopathic effect on seed germination and seedling growth of Rapido 344 lettuce variety. This study was conducted at Biology Laboratory of Uva Wellassa University, Sri Lanka in 2014 and experimental units were petri dishes in depths and diameters of 2 and 5 cm, respectively. The shoot and root length, dry weight, germination percentage were measured. The experimental results revealed that all the concentrations of both the weed extracts had inhibition effect on germination percentage, shoot & root length and dry weight of lettuce. The inhibitory effect of the extracts was concentration dependent. However, at 5% of C. dactylon extract did not significantly affect on seed germination and growth of seedlings. The highest degree of growth inhibition was observed in 20 % of both weed extracts.

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A new steroid glycoside and furochromones from Cyperus rotundus L.

Cited by 68 publications

References 38 publications

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

ALLELOPATHIC EFFECTS OF Cyperus rotundus L. AND Cynodan dactylon L. ON GERMINATION AND GROWTH RESPONSES OF LETTUCE (Lactuca sativa)

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