A new spectrophotometric method for the determination of gabapentin using chromotropic acid

Adegbolagun, Olayemi Modupe; Thomas, Olusegun E.; Aiyenale, Elizabeth O.; Adegoke, Olajire A.

doi:10.23893/1307-2080.aps.05621

Cited by 7 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17,18 Furthermore, this reaction has been developed by using other different aromatic amines and coupling reagents for pharmaceutical analyses such as antiepileptic drugs (i.e. gabapentin), 19 anti-malarial drugs, 20 and cephalosporin antibiotics (e.g. ceftriaxone, cefixime, and ceftazidime).…”

Section: Introductionmentioning

confidence: 99%

“…Chromotropic acid was chosen in this work instead of a conventional coupling reagent such as N -(1-naphthyl) ethylenediamine (NED) for its low toxicity. 28 It has been used as a chromogenic reagent for the detection of formaldehyde, 29 metal ions, 30 gabapentin drug, 19 and nitrite. 17 With the positively charged surface, the generated azo product could be attached to the PEI-sponge and the color of the material changed from white to pink in the presence of ceftazidime.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Digital image colorimetric detection of ceftazidime based on azo compound formation on a polyethyleneimine-modified cotton sponge

Hongtanee¹,

Praphairaksit²,

Unob³

2023

Analyst

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Digital image colorimetric detection of ceftazidime based on azo compound formation on a polyethyleneimine-modified cotton sponge

Hongtanee¹,

Praphairaksit²,

Unob³

2023

Analyst

View full text Add to dashboard Cite

show abstract

“…Chromotropic azo derivative has also found usefulness in the determination of trace oxalic acid (Zhai, Zhang, & Liu, 2007). Very recently, chromotropic acid was used for the sensitive determination of gabapentin in dosage forms (Adegbolagun, Thomas, Aiyenale, & Adegoke, 2018).…”

Section: Introductionmentioning

confidence: 99%

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

Adegoke

Thomas

Amao

et al. 2019

Arab Journal of Basic and Applied Sciences

Self Cite

View full text Add to dashboard Cite

In Nigeria, paracetamol is readily available in several retail outlets where the conditions of storage can be poor leading to elevated levels of para-aminophenol (PAP), which is known to be nephrotoxic and hepatotoxic. However, the routine analysis of PAP is mostly by chromatographic separation which requires expensive instrumentation not often available in developing countries. The objective of this research was to develop a sensitive colorimetric method for the quantification of PAP in paracetamol. The method was based on the diazo coupling reaction between diazotised PAP and chromotropic acid. Various reaction parameters critical for optimal detector response were optimized. The validation of the new method was done following the determination of parameters including repeatability, reproducibility and selectivity using current ICH guidelines. The new method was also applied to the assay of PAP in 14 paracetamol tablet samples. The calibration was linear between 0.0297 and 0.2229 mg/mL at 470 nm with limits of detection and quantification of 0.0061 and 0.0185 mg/mL, respectively. The recovery was in the range of 95.96 and 102.21 while intra-and inter-day precisions at three different concentrations did not exceed 4.03%. The new method was successfully applied to quantify PAP in paracetamol with percent content varying from 0.14 to 0.21%w/w. A simple and reliable method for the quantification of PAP has been developed and successfully employed to report, for the first time, the presence of the degradation product at levels beyond the allowable limits in paracetamol dosage forms in Nigeria.

show abstract

“…Several spectroscopic methods were developed for GBP analysis in pure form and in pharmaceutical formulations either with spectrophotometric or spectrofluorimetric determination. Due to the absence of strong absorbing chromophore in GBP, its direct spectrophotometric analysis is problematic and mostly depends on the derivatization with chemical reagents (Adegbolagun et al, 2018;Adegoke et al, 2018;Ambala and Patel, 2011;Fonseca et al, 2017;Gouda and Malah, 2013;Gujral et al, 2009;Saleh et al, 2014;Siddiqui et al, 2010). The official methods for the identification and quantitation analysis of GBP are prescribed in BP and USP (BP, 2015;USP 32, 2009).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of spectrophotometric method for determination of gabapentin in bulk and pharmaceutical dosage forms based on Schiff base formation with salicylaldehyde

2019

J App Pharm Sci

View full text Add to dashboard Cite

A sensitive, simple, and economic spectrophotometric method was developed and validated for the determination of gabapentin in pure form and pharmaceutical preparations. The method is based on Schiff base condensation reaction of the primary amino group of gabapentin with salicylaldehyde reagent in the presence of acetate solution at 45°C for 20 minutes. The obtained yellow-colored derivative in methanolic medium showed absorption maxima at 403 nm. Under the optimum conditions, Beer's law was obeyed in the concentration range of 6 to 100 μg/ml with correlation coefficient value of 0.9961. Limit of detection and limit of quantification were found to be 1.16 and 3.48 μg/ml, respectively. The validity of the described method was assessed according to the International Conference on Harmonization guidelines. The mean percentage recoveries ± SD were 100.57 ± 1.5 by applying the standard addition technique. The method was repeatable and precise (RSD ≤ 0.61% and ≤ 1.34%, respectively) and was successfully applied for the determination of the investigated drug in its pharmaceutical dosage form without detectable interference from the additives, hence, can be suggested for routine analysis of the gabapentin.

show abstract

A new spectrophotometric method for the determination of gabapentin using chromotropic acid

Cited by 7 publications

References 19 publications

Digital image colorimetric detection of ceftazidime based on azo compound formation on a polyethyleneimine-modified cotton sponge

Digital image colorimetric detection of ceftazidime based on azo compound formation on a polyethyleneimine-modified cotton sponge

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

Development and validation of spectrophotometric method for determination of gabapentin in bulk and pharmaceutical dosage forms based on Schiff base formation with salicylaldehyde

Contact Info

Product

Resources

About