A new spectrophotometric determination of famotidine from tablets

Abstract

A simple spectrophotometric method for determination of famotidine was described. The method was based on bromination of the drug with excess brominating mixture in acidic medium. The yellow colour developed was measured at 350 nm against distilled water blank. Beer's law was obeyed in the range of 40-200 µg/ml. 2-aminoiminomethyl)amino-]4 thiazolyl]methyl]thio]-N-(aminosulfonyl) propaninidamide, is used in the treatment of duodenal ulcer, gastric ulcer, stress ulcers and gastritis. Various methods have been reported for estimation of famotidine, which include spectrophotometric methods 1-3 , spectrophotometric and *For correspondence E-mail: ramireddy_m2000@yahoo.co.in spectrofluorimetric method 4 and flow-injection analysis 5 . Famotidine, chemically 3-[[[(In the present communication, a simple spectrophotometric method has been developed for the estimation of famotidine from pharmaceutical preparations. The proposed method was based on the bromination of the drug with excess brominating mixture in acidic medium. After bromination, the excess brominating mixture was treated with potassium iodide, which gave yellow colour. The maximum absorbance was measured at 350 nm. The

Instrumental analysis of some anti-ulcer drugs in different matrices

“…The method was based on the oxidation of the drug with alkaline potassium permanganate and measuring the rate of change of absorbance at λ max 610 nm. [42] Reddy et al, [43] described a bromination method for famotidine using excess bromine in acidic medium. The developed yellow color was measured spectrophotometrically at λ max 350 nm.…”

Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms

“…Since it is simple, cheap, quick, sensitive, selective, accurate, precise, widely available, and applicable for pharmaceutical analysis, visible spectrophotometry is widely used in quality control and clinical laboratories, hospitals, and pharmaceutical industries for the assay of various classes of drugs in pure form, pharmaceutical formulations, and biological samples To the best of our knowledge, only a handful of spectrophotometric approaches have been described for quantifying CQP in pharmaceutical dosage forms [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] (Table 1). NA: not available.…”

Spectrofluorimetric Determination of Some N. Containing Medicines Using Rhodamine 6G as a Chromogenic Reagent

“…It is an antiemetic drug used as an "anti-vomiting" drug for vomiting and nausea caused by diseases of the digestive tract, especially those that appear as side effects of other drug treatments, especially anti-cancer drugs or radiation therapy [5], and it is also used for anti-dopamine treatments for Parkinson's disease [6]. FAM, chemically named as 3-[({2-[(diaminomethylidene)amino]-1,3 -thiazol -4 -yl}methyl)sulfanyl] -N -sulfamoylpropanimidamid (III) is one of the medicines used to treat peptic ulcers, as it is considered a type II antihistamine (H 2 -receptor blockers) that inhibits the excessive secretion of stomach acid, eliminating heartburn especially in the stomach and esophagus, and speeding up the healing of ulcers [7][8][9]. PRO, chemically named as (RS)-1-(1-methylethylamino)-3-(1naphthyloxy)propan-2-ol (IV) known since 1965, was the first beta-blocker in common use (Fig.…”