A New Single Nucleotide Polymorphism in the IGF-I Gene and Its Association with Growth Traits in the Nanjiang Huang Goat

Zhang, Chunxiang; Zhang, Wei; Luo, Hailing; Yue, Wenbin; Ming-yu, Gao; Zhang, Jia

doi:10.5713/ajas.2008.70673

Cited by 44 publications

(45 citation statements)

References 35 publications

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“…It may be interesting to study more diverse breeds of the country to identify more SNPs in the region. 2 SNPs identified in exon 3 of IGF-1 gene and 1 new SNP at intron 4 of the IGF1 gene (Zhang et al 2008) but both of these fragments (exon 3 and intron 4) were monomorphic in our study. Therefore, further studies are needed to explore the existence of SNPs in exon 3 and intron 4 in other Indian goat breeds.…”

Section: Discussionmentioning

confidence: 82%

“…The 5′ UTR region of the IGF1 gene contains the G→A transition but no polymorphism was detected in this region by PCR-single-strand conformation polymorphism (SSCP) in 592 Nanjiang Huang goats (Zhang et al 2008). It may be interesting to study more diverse breeds of the country to identify more SNPs in the region.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have examined growth, skeletal, carcass, feeding, and immune function traits using candidate gene approach in goat, cattle, and chicken (Zhang et al 2008;Qiong et al 2011). …”

Section: Discussionmentioning

confidence: 99%

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Sequence characterization and genetic variability analysis of GHR, IGF1, and IGFBP-3 genes in nine Indian goat breeds

Sharma¹,

Dutt²,

Jayakumar³

et al. 2014

Journal of Applied Animal Research

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The genes that are part of the somatotropic axis play a crucial role in the regulation of growth and development of goat and other livestock animals. The identification of genetic polymorphisms in these genes will enable us to evaluate the biological relevance of such polymorphisms and to gain a better understanding of quantitative traits like growth. The present study was undertaken with the objective to analyze the caprine growth hormone receptor (GHR), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP-3) genes to gain insight into the polymorphisms in these genes across different indigenous goat breeds in a panel of 80 animals. The comparative gene sequence analysis in all Capra hircus breeds under study revealed 31 single nucleotide polymorphisms (SNPs) across different loci of GHR, IGF1, and IGFBP-3 genes. Out of 31 SNPs detected, 18, 8, and 5 SNPs were present in IGF-1, IGFBP-3, and GHR genes, respectively. All the mutations pointed out in the GHR and IGF1 genes were found to be synonymous and 6 of 8 SNPs in IGFBP-3 were found to be nonsynonymous. All the detected mutations were reported here for the first time. The frequencies of the SNPs were assessed in nine different goat breeds. Across breeds, the average frequency of the least frequent alleles ranged from 0.02 to 0.17.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sequence characterization and genetic variability analysis of GHR, IGF1, and IGFBP-3 genes in nine Indian goat breeds

Sharma¹,

Dutt²,

Jayakumar³

et al. 2014

Journal of Applied Animal Research

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“…Insulin-like growth factor (IGF)-I and -II play important roles in the regulation of skeletal muscle growth and act as mediators of growth hormone during muscle development and differentiation (Zhang et al, 2008;Wang et al, 2011). During postnatal skeletal muscle growth in vivo or in fully differentiated muscle cells, IGFs increase the rate of protein synthesis and decreases the rate of protein degradation, thereby enhancing myofiber hypertrophy (Le Grand and Rudnicki, 2007;Rhoads et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Association between DLK1 and IGF-I gene expression and meat quality in sheep

Su¹,

Sun²,

Li³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The aim of the present study was to detect delta-like 1 homolog (DLK1) and insulin-like growth factor-I (IGF-I) gene expression in the longissimus dorsi of Hu sheep at different growth stages and study the association between these genes and meat quality. The diameter and density of muscle fibers and tenderness of the longissimus dorsi were measured. Growth stage, but not sex, significantly affected DLK1 and IGF-I expression. DLK1 and IGF-I expression in the sheep longissimus dorsi gradually increased with growth, but also decreased during some periods. These results suggest that different growth stages significantly affect DLK1 and IGF-I gene expression in sheep muscle tissue. The expression of DLK1 and IGF-I genes were positively and significantly (P < 0.01) correlated with muscle fiber diameter and muscle fiber shear stress, and negatively and significantly (P < 0.01) correlated with muscle fiber density. Muscle fiber diameter was positively and significantly (P < 0.01) correlated with muscle fiber shear stress, and negatively and significantly (P < 0.01) correlated with muscle fiber density. In addition,

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“…Zhou et al (2005) found in the F2 generation of hybrids Leghorn×broiler Fayoum×broiler, a significant association (at 5% significance level) between IGF1-SNP and average daily gains. Some results of research on the IGF-1 gene polymorphism is associated with growth have been reported in chickens (Sco et al, 2001;Kita et al, 2005;Li et al, 2009), in sheep (Zhang et al, 2008) and in cattle (Curi et al, 2006;Siadkowska et al, 2006;Arman et al, 2012).…”

Section: Body Weight Gainmentioning

confidence: 99%

Association of Insulin-Like Growth Factor-1 Gene Polymorphism at 279 Position of the 5’UTR Region with Body Weight Traits in Broiler Chicken

Al-Hassani¹,

Al-Hassani²,

Abdul-Hass³

2015

Asian J. of Poultry Science

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Insulin-like Growth Factor 1 (IGF-1) gene has been described in several researches as a candidate gene for growth. The present study attempts to identify associations between body weight traits and polymorphism at 279 position of 5'UTR flanking region of IGF-1 gene in broiler chicken. Three hundred broiler chickens from two breeds (Cobb500 and Hubbard F-15) were used in this study. A Single Nucleotide Polymorphism (SNP) at 279 position of 5'UTR region of IGF-1 gene was identified in 20.6 and 60.3% of Cobb500 and Hubbard F-15, respectively, using PCR-RFLP technique. Allele frequencies were 83.87 and 42.80% for T allele and 16.13 and 57.20% for C allele in Cobb500 and Hubbard -15 breeds, respectively. Genotype frequencies were 79.35, 9.03 and 11.61% in Cobb500 and 39.73, 6.16 and 54.11% in Hubbard F-15 for TT, TC and CC genotypes, respectively. As related with mean body weight, different weekly results were noted between Cobb500 and Hubbard F-15 according to genotypes during a period from 3-7 weeks of age. Within all genotypes, the mean body weights were higher (p>0.05) in males than females at 5 and 7 weeks of age. As related with body weight gain, Hubbard F-15 broilers were more affected by IGF-1 genotypes than Cobb500 broilers in the last three weeks of age, also, male broilers were more affected by IGF-1 genotypes than female broilers. The results of this study demonstrated that IGF-1 gene, to some extent, could be a candidate gene that affects growth in broiler chickens.

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A New Single Nucleotide Polymorphism in the IGF-I Gene and Its Association with Growth Traits in the Nanjiang Huang Goat

Cited by 44 publications

References 35 publications

Sequence characterization and genetic variability analysis of GHR, IGF1, and IGFBP-3 genes in nine Indian goat breeds

Sequence characterization and genetic variability analysis of GHR, IGF1, and IGFBP-3 genes in nine Indian goat breeds

Association between DLK1 and IGF-I gene expression and meat quality in sheep

Association of Insulin-Like Growth Factor-1 Gene Polymorphism at 279 Position of the 5’UTR Region with Body Weight Traits in Broiler Chicken

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