A new sensitive approach for spectrofluorimetric assay of Milnacipran and Amisulpride in real plasma and pharmaceutical preparations via complexation with Eosin Y dye

Atia, Noha N.; Marzouq, Mostafa A.; Hassan, Ahmed I.; Eltoukhi, Walid E.

doi:10.1016/j.saa.2019.02.071

Cited by 12 publications

(9 citation statements)

References 14 publications

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“…Therefore, eosin Y was applied to determine several pharmaceutical compounds using spectrophotometric, [ 11,26,27 ] spectrofluorimetric, [ 28–30 ] or both spectrophotometric and spectrofluorimetric [ 31–33 ] methods by forming either binary or ternary complexes. Due to binary complex formation of eosin Y with CFX, a quenching effect was produced on the native fluorescence of eosin Y at λ ex.…”

Section: Resultsmentioning

confidence: 99%

Determination of cefixime in pure form, in pharmaceutical products and biological samples through fluorescence quenching of eosin Y

2020

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A simple, economic and validated spectrofluorimetric method was developed to assay cefixime (CFX). The technique relies on the quenching effect of CFX on the fluorescence intensity of eosin Y in the presence of acetate buffer pH 3.4 to produce an ion‐pair complex that is measured at 549 nm using an excitation wavelength of 300 nm. Reaction‐influencing factors were carefully investigated and optimized. The fluorescence quenching value was linear to the CFX concentration in the range 0.2–40 μg/ml with a correlation coefficient of 0.992. The calculated limit of detection and limit of quantification were found to be 0.00242 and 0.0080 μg ml−1, respectively. The selectivity of the method was confirmed by studying the effects of excipients and no interference was distinguished. The developed method was used to determine CFX in marketable products and in biological samples. To validate the method, directives of the International Conference on Harmonization were applied and per cent recoveries obtained ranged from 95.30 to 102.50% for pharmaceutical products and from 97.00 to 103.00% for biological fluids.

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Section: Resultsmentioning

confidence: 99%

Determination of cefixime in pure form, in pharmaceutical products and biological samples through fluorescence quenching of eosin Y

2020

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“…The chemical structure of milnacipran hydrochloride (MCN). Several analytical assays were described for the detection of MCN in dosage forms and in biological fluids such as spectrophotomety (4-14) (Table 1), spectrofluorimetry (15,16), high-performance liquid chromatography (HPLC) (17)(18)(19)(20)(21)(22)(23)(24), high-performance Thin layer chromatography (HPTLC) (25)(26)(27). Most of the reported procedures for the determination of MCN suffer from the use of complex instruments, the need high expertise in their use, in Utilization of ion-pair complexation reaction for the spectrophotometric determination of milnacipran HCl as anti-depression drug in pharmaceutical formulations addition the unavailability of these instruments in several quality control laboratories.…”

Section: Hclmentioning

confidence: 99%

Utilization of ion-pair complexation reaction for the spectrophotometric determination of milnacipran HCl as anti-depression drug in pharmaceutical formulations

Gouda

El-Sheikh

Fawzy

et al. 2023

Bulletin of Faculty of Science, Zagazig University

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The present part aims to develop and validate a simple, rapid, cost-effective, sensitive and extractive spectrophotometric methods for the determination of anti-depression drug; milnacipran HCl in pure form and pharmaceutical formulations. The developed methods are based on the formation of ion-pair complexes between milnacipran HCl with three dyes, namely, bromocresol purple (BCP), bromophenol blue (BPB), or methyl orange (MO) in acidic buffer solutions. Different factors affecting the reaction between milnacipran HCl and the dyes were studied and optimized. The formed complexes were extracted with methylene chloride and measured at 408, 413, and 423 nm using BCP, BPB and MO, respectively. The beer's law was obeyed in the ranges 1.0-14, 2.0-20 and 1.0-18 μg mL −1 using BCP, BPB and MO, respectively under the optimum conditions. The composition of the ion pairs was found 1:1. The molar absorptivity's, Sandell's sensitivity, the limits of detection and quantification were calculated. Other method validation parameters, such as accuracy, intra-day and inter-day (1.60 and 1.80%) as precision, robustness, ruggedness and selectivity, have been evaluated. The proposed methods have been applied successfully for the analysis of milnacipran HCl in pure form and pharmaceutical formulations. The reliability of the methods was further ascertained by performing recovery studies using the standard addition method. Statistical comparison of the results with the reported method was performed by applying student's t-and F-tests and no significant statistical differences were obtained.

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“…High concentration of dyeing wastewater discharge way has caused a series of problems such as soil saline–alkalization (Xia et al., 2018). Eosin Y has been widely used as a textile and art dye, and now it is very popular in detection field for many pharmaceutical preparations (Atia, Marzouq, Hassan, & Eltoukhi, 2019). Eosin Y enters the environment through human activities, and it is not only very toxic to aquatic organisms, but also threatens human health (Goswami & Das, 2019).…”

Section: Introductionmentioning

confidence: 99%

Adsorption of toxic dye Eosin Y from aqueous solution by clay/carbon composite derived from spent bleaching earth

Liu

Chen

Shi

et al. 2020

Water Environment Research

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The environmentally friendly clay/carbon composite (SBE/C) was prepared by onestep pyrolysis under N 2 atmosphere at 700°C of spent bleaching earth (SBE) from the industrial waste of the refined oil industry. SBE/C was tested to remove anionic dye Eosin Y from aqueous water. The results revealed that SBE/C had larger specific surface area than SBE, and the equilibrium adsorption capacity of SBE/C (11.15 mg/g) was about 3 times than that of SBE (4.04 mg/g). The adsorption process was found to be exothermic and spontaneous. The adsorption capacity of SBE/C was independent on pH (5-12), and exhibits satisfactorily recyclable performance. Combined with characterization analysis, the adsorption mechanism likely includes electrostatic interaction, hydrogen bonding, hydrophobic interaction, halogen bonding, and π-π interaction. Overall, this exploration of SBE/C might open a window to the design of an efficient and low-cost adsorbent for Eosin Y dye elimination from wastewater.

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A new sensitive approach for spectrofluorimetric assay of Milnacipran and Amisulpride in real plasma and pharmaceutical preparations via complexation with Eosin Y dye

Cited by 12 publications

References 14 publications

Determination of cefixime in pure form, in pharmaceutical products and biological samples through fluorescence quenching of eosin Y

Determination of cefixime in pure form, in pharmaceutical products and biological samples through fluorescence quenching of eosin Y

Utilization of ion-pair complexation reaction for the spectrophotometric determination of milnacipran HCl as anti-depression drug in pharmaceutical formulations

Adsorption of toxic dye Eosin Y from aqueous solution by clay/carbon composite derived from spent bleaching earth

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