A New Self Microemulsifying Mouth Dissolving Film

Pattewar, Seema; Kasture, Sanjay; Pande, Vishal Vivek; Sharma, Swapnil

doi:10.5530/ijper.50.3.29

Cited by 9 publications

(4 citation statements)

References 11 publications

(11 reference statements)

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“…However, Pouton [ 13 , 14 , 15 , 16 ] only suggested utilizing SEDDSs in 1985 as the first concrete solution towards improving lipophilic drug delivery via the oral route of administration. Despite several decades devoted to SEDDS development for various routes of administration, namely: oral, rectal, vaginal, ocular and nasal; the dermal route has remained relatively untouched [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. The formidable barrier provided by the outermost skin layer can possibly be conquered by SEDDSs as these isotropic, thermodynamically stable mixtures, comprising oil, surface active agents and water, have the potential capacity to facilitate entry of drugs into underlying skin layers [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

2020

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A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and water-titration experiments identified spontaneous emulsification capacity of different excipient combinations and clofazimine. After identifying self-emulsification regions, check-point formulations were selected within the self-emulsification region by considering characteristics required to achieve optimized topical drug delivery. Check-point formulations, able to withstand phase separation after 24 h at an ambient temperature, were subjected to characterization studies. Experiments involved droplet size evaluation; size distribution; zeta-potential; self-emulsification time and efficacy; viscosity and pH measurement; cloud point assessment; and thermodynamic stability studies. SEDDSs with favorable properties, i.e., topical drug delivery, were subjected to dermal diffusion studies. Successful in vitro topical clofazimine delivery was observed. Olive oil facilitated the highest topical delivery of clofazimine probably due to increased oleic acid levels that enhanced stratum corneum lipid disruption, followed by improved dermal clofazimine delivery. Finally, isothermal microcalometric experiments studied the compatibility of excipients. Potential interactions were depicted between argan oil and clofazimine as well as between Span®60 and argan-, macadamia- and olive oil, respectively. However, despite some mundane incompatibilities, successful development of topical SEDDSs achieved enhanced topical clofazimine delivery.

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Section: Introductionmentioning

confidence: 99%

Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

2020

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“…SEDDSs were originally developed from emulsions in order to generate a more physically stable formulation that is easier to prepare and can be used for oral drug delivery, as exemplified by their development specifically for oral administration of the immunosuppressant cyclosporine [ 178 , 185 , 186 ]. More recent activities focus on developing SEDDSs for other drug delivery routes of administration such as via the ocular-, vaginal- and sublingual routes [ 186 , 187 , 188 , 189 , 190 ]. Additionally, use of SEDDSs for treatment of dermal pathologies have been described [ 191 , 192 ].…”

Section: The Prospect Of Self-double-emulsifying Drug Delivery System...mentioning

confidence: 99%

Adapting Clofazimine for Treatment of Cutaneous Tuberculosis by Using Self-Double-Emulsifying Drug Delivery Systems

2022

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Although chemotherapeutic treatment regimens are currently available, and considerable effort has been lavished on the development of new drugs for the treatment of tuberculosis (TB), the disease remains deeply intractable and widespread. This is due not only to the nature of the life cycle and extraordinarily disseminated habitat of the causative pathogen, principally Mycobacterium tuberculosis (Mtb), in humans and the multi-drug resistance of Mtb to current drugs, but especially also to the difficulty of enabling universal treatment of individuals, immunocompromised or otherwise, in widely differing socio-economic environments. For the purpose of globally eliminating TB by 2035, the World Health Organization (WHO) introduced the “End-TB” initiative by employing interventions focusing on high impact, integrated and patient-centered approaches, such as individualized therapy. However, the extraordinary shortfall in stipulated aims, for example in actual treatment and in TB preventative treatments during the period 2018–2022, latterly and greatly exacerbated by the COVID-19 pandemic, means that even greater pressure is now placed on enhancing our scientific understanding of the disease, repurposing or repositioning old drugs and developing new drugs as well as evolving innovative treatment methods. In the specific context of multidrug resistant Mtb, it is furthermore noted that the incidence of extra-pulmonary TB (EPTB) has significantly increased. This review focusses on the potential of utilizing self-double-emulsifying drug delivery systems (SDEDDSs) as topical drug delivery systems for the dermal route of administration to aid in treatment of cutaneous TB (CTB) and other mycobacterial infections as a prelude to evaluating related systems for more effective treatment of CTB and other mycobacterial infections at large. As a starting point, we consider here the possibility of adapting the highly lipophilic riminophenazine clofazimine, with its potential for treatment of multi-drug resistant TB, for this purpose. Additionally, recently reported synergism achieved by adding clofazimine to first-line TB regimens signifies the need to consider clofazimine. Thus, the biological effects and pharmacology of clofazimine are reviewed. The potential of plant-based oils acting as emulsifiers, skin penetration enhancers as well as these materials behaving as anti-microbial components for transporting the incorporated drug are also discussed.

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“…Flavors used for taste masking of different tastes are given in Table 6. Method of Preparation: [57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75] Different methods for preparation of oral films is shown in Fig. 1…”

Section: Flavoring Agentsmentioning

confidence: 99%

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2020

IJPSR

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In the development of a new drug molecule, there are many problems with respect to the dissolution, absorption, and bioavailability. Thus, formulation scientists are majorly focusing on the development of the formulation, which will increase the efficacy of the existing drugs. Oral dispersible films are one of such a novel approach. In given review article, the advantages of oral dispersible films over other oral dosage form and especially over oral dispersible tablets and their applications are discussed. In further part the major advantages regarding first-pass metabolism, disable patients, fast onset, etc., are covered. Furthermore, the overview of all the ingredients used in the formulation of fast dissolving films with the evaluation of these films is discussed in the given review article. Solvent casting, semisolid casting, hot-melt extrusion, solid dispersion extrusion, rolling are the methods which are employed, along with the evaluation parameters like thickness, tear resistance, dryness test of the prepared films are also explored in the article. This review article gives a complete overview of oral dispersible films and their novel approach in the formulation. INTRODUCTION: Among the delivery routes, the oral route is the most acceptable with respect to patient compliance. Many pharmaceutical firms have directed their research activity in reformulating existing drugs into new dosage forms. One such relatively new dosage form is the oral film, a thin film that is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity. Developing formulations for children has been a challenging task. Amongst other factors, the palatability of formulations of pediatric oral medications is one of the most significant factors influencing compliance with therapeutic regimens 1, 2 .

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A New Self Microemulsifying Mouth Dissolving Film

Cited by 9 publications

References 11 publications

Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

Adapting Clofazimine for Treatment of Cutaneous Tuberculosis by Using Self-Double-Emulsifying Drug Delivery Systems

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