A new SeDeM-SLA expert system for screening of solid carriers for the preparation of solidified liquids: A case of citronella oil

Shah, Devanshi S.; Jha, Durgesh K.; Gurram, Sharda; Suñé-Pou, Marc; García-Montoya, Encarnación; Amin, Purnima D.

doi:10.1016/j.powtec.2021.01.019

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…In the case of compressed chewing gums, additional parameters should be added to the SeDeM Expert System diagrams, in order to ensure successful formulation development, such as friability, indicating tablet mechanical properties, and chewability, as the critical quality attribute of compressed chewing gum (24). Shah et al (25) modified the SeDeM Expert System in order to obtain an expert system suitable for liquid carrier/adsorbent characterization, i.e. the SeDeM-SLA (Solid-Liquid Adsorption).…”

Section: Expert System For Drug Developmentmentioning

confidence: 99%

“…the ratio between oil and carrier amount in the mixture. It was found that the SeDeM-SLA Expert System represents a useful tool for carrier selection, superior to the conventional trialerror approach (25). Similarly, Mamidi et al (26) applied the SeDeM Expert System framework in order to identify the most suitable diluent for liquisolid formulation.…”

Section: Expert System For Drug Developmentmentioning

confidence: 99%

“…One of the major advantages of the SeDeM Expert System are simple and common characterization methods included, which are widely available in research and development laboratories. It is easy to implement additional parameters, depending on the powder and final dosage form properties, such as the Percent of oil released spontaneously, Adsorption capacity, Mean yield pressure and Compactibility parameter etc (25)(26). Some parameters included in the SeDeM Expert System are interdependent, e.g.…”

Section: Expert System For Drug Developmentmentioning

confidence: 99%

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Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

Vasiljević¹,

Turković²,

Aleksić³

et al. 2022

Arhiv za farmaciju

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An understanding of material properties and processing effects on solid dosage forms performance is required within the Quality-by-design approach to pharmaceutical development. Several research groups have developed mathematical approaches aiming to facilitate the selection of formulation composition and the manufacturing technology. These approaches are based on material particulate, bulk and compression-related properties. This paper provides theoretical assumptions and a critical review of different mathematical approaches for processability characterization of powders and multiparticulate units. Mathematical approaches have mainly been developed for directly compressible materials, but sometimes other manufacturing technologies, such as roller compaction and wet granulation, are also considered. The obtained compact tensile strength has been implemented in the majority of approaches, as an important characteristic describing compact mechanical properties. Flowability should be also evaluated, since it affects sample processability. Additionally, particle size and shape, material density and compressibility, compactibility and tabletability profiles have been also distinguished as relevant properties for solid dosage form development. The application of mathematical approaches may contribute to the mechanistic understanding of critical material attributes and facilitate dosage form development and optimization. However, it is essential to select the appropriate one, based on the intended dosage form characteristics, in order to ensure that all relevant powder/multiparticulate units characteristics are implemented and critically evaluated.

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Section: Expert System For Drug Developmentmentioning

confidence: 99%

Section: Expert System For Drug Developmentmentioning

confidence: 99%

Section: Expert System For Drug Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

Vasiljević¹,

Turković²,

Aleksić³

et al. 2022

Arhiv za farmaciju

View full text Add to dashboard Cite

show abstract

“…On the other hand, environmental factors such as temperature and humidity also affect the powder flow unless the powder is inert and non-hygroscopic [ 19 ]. The addition of formulation excipients, even in small quantities, affects the powder flow properties [ 20 ]. Table 1 summarizes powder flow parameters and their effect on powder properties.…”

Section: Introductionmentioning

confidence: 99%

A concise summary of powder processing methodologies for flow enhancement

Shah,

Moravkar,

Jha

et al. 2023

Heliyon

Self Cite

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“…There are various approaches that have been developed to reduce or eliminate surfactant use. These approaches are biopolymer conjugates and complexes [14][15][16][17], pickering stabilization with colloidal particles [18][19][20] and solidification of the oil phase [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

ERGİN¹,

Inal²,

BARAKAT³

2023

jrp

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Curcumin has been used in many diseases due to its high therapeutical potential in recent years. Although curcumin is a frequently used natural polyphenolic compound products, its low solubility and poor permeability limits the dermal efficacy of curcumin. Emulgels are a new generation of semi-solid formulations that combine the advantages of both emulsions and gels. The biggest limitation of emulsions is surfactant related irritation problems caused by the use of high amount of surfactants. In this study, it was aimed to increase the skin permeability of curcumin by developing surfactant-free emulgel formulations. In the study, emulgels were developed by Carbopol 940 gels as the aqueous phase, olive oil and curcumin methanol solution as the oil phase. No surfactant was used additionally to show the stabilizing effect of Carbopol in emulgels. The emulgel formulations were subjected to physicochemical characterization by means of organoleptic properties, pH, rheological and mechanical properties. Mechanical properties were carried out by texture profile analyzes to determine the structure related properties such as hardness, compressibility, adhesiveness, cohesiveness and elasticity. The spreadability of the formulations was also determined with Texture Analyzer. Obtained emulgels showed good rheological, mechanical and spreadability properties. The transdermal permeation of the chosen emulgel was studied ex vivo against hydrogel prepared with the same amount of Carbopol. The emulgel formulation significantly increased transdermal permeation compared to the hydrogel. This emulgel formulation successfully passed from stress tests. As a conclusion, the novel surfactant-free emulgel formulation was successfully developed to increase curcumin permeation through the rat skin.

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A new SeDeM-SLA expert system for screening of solid carriers for the preparation of solidified liquids: A case of citronella oil

Cited by 9 publications

References 38 publications

Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

A concise summary of powder processing methodologies for flow enhancement

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

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