A concise summary of powder processing methodologies for flow enhancement

Shah, Devanshi S.; Moravkar, Kailas K.; Jha, Durgesh K.; Lonkar, Vijay; Amin, Purnima D.; Chalikwar, Shailesh S.

doi:10.1016/j.heliyon.2023.e16498

Cited by 7 publications

(3 citation statements)

References 88 publications

(146 reference statements)

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“…Though the formulations containing ASD-IBP prepared by MF and FD methods have identical dissolution behavior, the pre and postcompression characters differ between the drying approaches. The difference in pre and postcompression parameters between MF and FD might be due to the agglomeration of particles or collapse of the porous structure in the FD process, affecting the flowability and compressibility of the powder [ 52 ]. Hence, ASD prepared by MF, can produce particles with excellent uniformity and controlled particle size distribution, improving compressibility and tablet uniformity.…”

Section: Resultsmentioning

confidence: 99%

Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions

Uddin,

Halder,

Deb

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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This study aims to improve the biopharmaceutical, mechanical, and tableting properties of a poorly soluble drug, ibuprofen (IBP), by preparing amorphous solid dispersion (ASD) followed by a sustained-release tablet formulation. A suitable polymer to develop an ASD system was chosen by utilizing the apparent solubility of IBP in various polymer solutions. ASDs containing various ratios of IBP and selected polymer were prepared by the melt fusion (MF) method. ASD containing optimized drug-polymer ratio prepared by freeze-drying (FD) method was characterized and compared physicochemically. The solubility of IBP in water increased 28-fold and 35-fold when formulated as ASD by MF and FD, respectively. Precise formulations showed amorphization of IBP and increased surface area, improving solubility. The dissolution pattern of optimized ASD-IBP in pH 6.8 phosphate buffer after 60 min in MF and FD was enhanced 3-fold. In addition, direct compression tablets comprising optimized ASD granules from MF and FD were made and assessed using compendial and noncompendial methods. ASD-IBP/MF and ASD-IBP/FD formulations showed a similar drug release profile. In addition, 12 h of sustained IBP release from the ASD-IBP-containing tablets was obtained in a phosphate buffer with a pH of 6.8. From the dissolution kinetics analysis, the Weibull model fitted well. The drug release pattern indicated minimal variations between tablets formed using ASD-IBP prepared by both procedures; however, pre- and postcompression assessment parameters differed. From these findings, the application of ASD and sustained-release polymers in matrix formation might be beneficial in improving the solubility and absorption of poorly soluble drugs such as IBP.

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Section: Resultsmentioning

confidence: 99%

Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions

Uddin,

Halder,

Deb

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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“…Our methodology integrates a central composite experimental design to explore these parameters’ impact on flow properties systematically. This approach allows us to delineate each variable’s influence and interactions, as supported by significant empirical evidence [ 18 , 19 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…Our methodology integrates a central composite experimental design to explore these parameters' impact on flow properties systematically. This approach allows us to delineate each variable's influence and interactions, as supported by significant empirical evidence [18][19][20]. Pellets were produced using a 1000 mL laboratory high-shear mixer (Pro-C-epT 4M8 Granulator, Zelzate, Belgium) with a three-blade impeller and a chopper.…”

Section: Production Of Samplesmentioning

confidence: 99%

Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties

Farkas,

Nagy,

Dévay

et al. 2024

Pharmaceutics

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The flow properties of pellets or granules are crucial for further processing drug dosage forms. Optimal compression or filling of multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques have been developed to examine flowability, including static and dynamic methods applying empirical studies and up-to-date chaos theory; however, the newest methods seem only to be powerful with the supplementation of empirical principles. Our experiments try to refine both the technique of analysis and the methods, by finding new, alternative ways. Our approach to the flowability measurements was to set up a dynamic time-dependent model that combined empirical observations and chaos theory on a geometrical basis, thus finding new characteristics regarding the flow properties of pellets and granules that could be relevant for drug developers. Our findings indicate that sphericity and particle size are the most significant factors influencing the flowability of pharmaceutical multiparticular preparations. Furthermore, this study confirms that integrating chaos theory and empirical observations in a time-dependent dynamic model provides a comprehensive understanding of particle flow behavior, pivotal for optimizing manufacturing processes.

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Impact of two-step glidant mixing process on flow performance of coated curcumin - In vitro, in vivo investigation

Laddha,

Girase,

Bhairav

et al. 2024

European Journal of Medicinal Chemistry Reports

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A concise summary of powder processing methodologies for flow enhancement

Cited by 7 publications

References 88 publications

Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions

Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions

Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties

Impact of two-step glidant mixing process on flow performance of coated curcumin - In vitro, in vivo investigation

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