A New Quantitative Index for Baseline Renal Transplant Scintigraphy With 99mTc-DTPA in Evaluation of Delayed Graft Function and Prediction of 1-Year Graft Function

Yazıcı, Bülent; Oral, Aylin; Gokalp, Cenk; Akgün, Ayşegül; Töz, Hüseyin; Hoşçoşkun, Cüneyt

doi:10.1097/rlu.0000000000001020

Cited by 16 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ 8 ] A more recent article by Yazici et al, described a high sensitivity and specificity (86.1% and 86.2%) for the identification of DGF by using the relatively new index graft index (GI) in 179 patients. [ 9 ] Since our study was focusing on Tc-99m MAG3 RS, we were again unable to apply this new Tc-99m DTPA RS curve index. However, the presence of DGF is generally detected by serum creatinine measurement and RS is only of additional value if it can provide information on the cause of DGF or the prognosis.…”

Section: Discussionmentioning

confidence: 99%

Can transplant renal scintigraphy predict the duration of delayed graft function? A dual center retrospective study

et al. 2018

View full text Add to dashboard Cite

IntroductionThis study focused on the value of quantitatively analyzed and qualitatively graded renal scintigraphy in relation to the expected duration of delayed graft function after kidney transplantation. A more reliable prediction of delayed graft function duration may result in a more tailored and patient-specific treatment regimen post-transplantation.MethodsFrom 2000 to 2014, patients with early transplant dysfunction and a Tc-99m MAG3 renal scintigraphy, within 3 days post-transplantation, were included in a dual center retrospective study. Time-activity curves of renal scintigraphy procedures were qualitatively graded and various quantitative indices (R20/3, TFS, cTER, MUC10) were combined with a new index (Average upslope). The delayed graft function duration was defined as the number of days of dialysis-based/functional delayed graft function.ResultsA total of 377 patients were included, with a mean age (± SD) of 52 ± 14 years, and 58% were male. A total of 274 (73%) patients experienced delayed graft function≥ 7 days. Qualitative grading for the prediction of delayed graft function≥ 7 days had a sensitivity and specificity of respectively 87% and 65%. The quantitative indices with the most optimal results were cTER (76% sensitivity, 72% specificity), and Average upslope (75% sensitivity, 73% specificity).ConclusionsQualitative renal scintigraphy grading and the quantitative indices cTER and Average upslope predict delayed graft function ≥ 7 days with a high sensitivity. This finding may help to support both clinicians and patients in managing early post-operative expectations. However, the specificity is limited and thus renal scintigraphy does not reliably help to identify patients in whom the course of delayed graft function is longer than anticipated.

show abstract

Section: Discussionmentioning

confidence: 99%

Can transplant renal scintigraphy predict the duration of delayed graft function? A dual center retrospective study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Each ROI was firstly drawn automatically and then manually corrected by the same technician, and in every case, the same nuclear medicine physician confirmed the ROIs. Once the ROIs were drawn, the software automatically calculated the glomerular filtration rate (GFR), the Hilson perfusion index [9] (100 × [area under arterial curve to peak] / [area under renal curve]), time (s) between the peaks of the iliac and graft perfusion curves (ΔP)[13], and time (s) for the declining counts on the renal perfusion curve to reach half of the peak value (T½ of graft washout; GW½) [5, 13] of renal perfusion.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have revealed good results with scintigraphy in transplanted kidneys. Most of these studies have relied on early scanning, which was performed within 4 days, and even at 1 day, post transplant [3, 4, 5, 6, 7, 8, 9, 10, 11], and a comparison of post transplant scans at 3 days and 7 days postoperatively in the same patient seemed to show that only the post transplant day-3 scan could predict the graft outcome [10]. However, for various reasons, early scanning is not always possible, as is the situation at our institution, where renal scans are not routinely performed until approximately 1 week after transplant.…”

Section: Introductionmentioning

confidence: 99%

“…Among the parameters from DTPA scan, Kirchner’s index, Hilson’s index, the kidney-to-aorta ratio, graft washout, time difference between peak renal perfusion count and peak arterial count, peak renal perfusion count/counts at plateau, peak renal perfusion/peak renal uptake, renal counts at 20 min/renal counts at 3 min, and others, may be evaluated to assess graft function [8]. One group has recently reported a new index for predicting graft function based on a formula using existing variables [5], but as yet, there has been no consensus about which indices are most useful [6, 12]. In addition, in routine clinical practice, the parameters mentioned above are not all easy to obtain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Using post transplant 1 week Tc-99m DTPA renal scan as another method for predicting renal graft failure

Chong

Choi

et al. 2019

Open Medicine

View full text Add to dashboard Cite

AbstractPurposeThe aims of this study were to determine whether post transplant renal scan performed at around 1 week can predict graft failure, and to identify the best predictive factors among easy-to-measure variables.Materials and methodsWe retrospectively evaluated patients who underwent Tc-99m DTPA renal scan at approximately 1 week after renal transplantation. They were separated into two categories at 3 months after the operation; graft failure and non-failure. Graft failure was confirmed by biopsy (rejection). Non-failure was confirmed either by biopsy or clinical follow-up with serum creatine (Cr). Scan parameters including glomerular filtration rate (GFR), Hilson perfusion index, peaks of the iliac and graft perfusion curves were analyzed. Clinical variables including age, sex, height, weight, systolic blood pressure, serum Cr, type of donated kidney, side of transplant, and immunosuppressant were also analyzed.ResultsAmong total 45 patients, graft failure was present in 11 cases. The serum Cr level was significantly higher in the failure group. Among scan variables, only the GFR was significantly different between groups. GFR of <44.48 mL/min was predictive of graft failure (sen 88.9%). Serum Cr level >2.13 mg/dL was also predictive (sen 72.7%).ConclusionGFR on renal scan at approximately 1 week after kidney transplant can predict graft failure.

show abstract

“…Tc-99m DTPA ile yapılan bazal TBS'den elde edilen GI'nın ise hem DGF hem de uzun dönemde greft disfonksiyonunu öngörmede diğer indekslerden daha iyi olduğu anlaşılmaktadır (15,16,17).…”

Section: Bazal Transplant Böbrek Sintigrafisinin Prognostik Değeriunclassified

Renal Transplant Scintigraphy

Yazıcı¹

2019

nts

View full text Add to dashboard Cite

A New Quantitative Index for Baseline Renal Transplant Scintigraphy With 99mTc-DTPA in Evaluation of Delayed Graft Function and Prediction of 1-Year Graft Function

Cited by 16 publications

References 28 publications

Can transplant renal scintigraphy predict the duration of delayed graft function? A dual center retrospective study

Can transplant renal scintigraphy predict the duration of delayed graft function? A dual center retrospective study

Using post transplant 1 week Tc-99m DTPA renal scan as another method for predicting renal graft failure

Renal Transplant Scintigraphy

Contact Info

Product

Resources

About