A new pyrene based highly sensitive fluorescence probe for copper(ii) and fluoride with living cell application

Goswami, Shyamaprosad; Chakraborty, Surajit; Paul, Sima; Halder, Sandipan; Panja, Sukanya; Mukhopadhyay, Subhra Kanti

doi:10.1039/c4ob00067f

Cited by 77 publications

(33 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondly, introduction of chelating groups like, -C=N and -C=O should encourage strong binding with specific metal ions [14].…”

Section: Synthesis and Photophysical Propertiesmentioning

confidence: 99%

“…In recent years, considerable efforts have been made to develop some good small synthetic organic molecular scaffolds/chemosensors to detect F -and Cu 2+ ions through the naked-eye sensitive colorimetric and fluorescence responses [13][14][15][16]. However, chemosensors which can display enhanced "turn-on" emission upon interaction with Cu 2+ and F -ions are limited in number [3,17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A coumarin-derived useful scaffold exhibiting Cu2+ induced fluorescence quenching and fluoride sensing (On–Off–On) via copper displacement approach

Razi

Srivastava

Ali

et al. 2015

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

“…Secondly, introduction of chelating groups like, -C=N and -C=O should encourage strong binding with specific metal ions [14].…”

Section: Synthesis and Photophysical Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A coumarin-derived useful scaffold exhibiting Cu2+ induced fluorescence quenching and fluoride sensing (On–Off–On) via copper displacement approach

Razi

Srivastava

Ali

et al. 2015

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

“…The metal binding properties of the receptors were assessed by the addition of the alkali and alkaline earth metal ions as well as transition metals. Goswami et al 127 reported a new pyrene based fluorescence probe 56 (Fig. However, in case of competition experiment with 100 eq.…”

Section: Pyrene Based Cu 2+ Sensormentioning

confidence: 99%

Optical sensor: a promising strategy for environmental and biomedical monitoring of ionic species

2015

View full text Add to dashboard Cite

There is fast growing research on designing and improving the metal recognition methodologies in the ecosystems and biological media. The fluorescent based techniques proved a mile stones for non-invasive metal sensation and quantification in the multichannel environment. Metals as the natural components of Earth's crust are generally present in trace concentrations in the environmental samples where the humic substances have complexation affinity toward them. Iron, zinc and copper are the 1 st , 2 nd and 3 rd adequate elements indispensable to the body in trace playing the crucial roles in many biological processes. However, the unregulated amounts either as excess or deficient may exacerbate deterioration to the vital organs and triggered the progression of complications. Beside these three essential elements, mercury is widely considered to be one of the most hazardous pollutants and highly dangerous elements due to its recognized accumulative and toxic characters in the environment and the ecosystem. In the current scenario, we have tried to summarize the maximum amount of recently developed fluorescent signaling materials for the Cu 2+ , Fe 2+ / Fe 3+ , Zn 2+ and Hg 2+ . The spectral shifting in the molecules on metal chelation, mode of complexation and stoichiometries of resulting adducts have been discussed in detail. Furthermore, the molecules which have been reported as intracellular metal detector via bioimaging are specifically highlighted that might be useful for the design and development of cell viable and membrane permeable molecular probes in the future perspective.

show abstract

“…Similarly, isoxazolidinyl polycyclic aromatic hydrocarbons showed moderate DNA intercalating activity and cytotoxicity . Novel pyrene‐based probes were designed and reported for the purpose of the selective sensor of Cu(II) and for live cell imaging . Our present work describes the pyrene‐linked pyrroles with extensive π‐conjugation act as chromophore and these molecules have been improved for their material application in particular toward bio‐imaging.…”

Section: Introductionmentioning

confidence: 99%

Live cell imaging of bacterial cells: Pyrenoylpyrrole‐based fluorescence labeling

Divakar

Shanmugam

2017

Chem Biol Drug Des

View full text Add to dashboard Cite

A novel substituted pyrenoylpyrroles was synthesized by the reaction of pyrenoyl chalcone, TosMIC and methyl iodide under mild condition. All the synthesized compounds were screened for their bioactivity, and the MIC was determined, among which few compounds showed moderate antibacterial activity toward Gram-positive as well as Gram-negative bacteria. Further, cytotoxicity assay ascertained that these compounds were non-toxic to mammalian cells as well. The pyrene chromophore in the synthesized compounds (3a-e) and (5a-e) is responsible for the good photophysical properties which have an absorbance at λ 340 nm and emission at λ 410 nm. Hence, two of the selected novel synthesized compounds with non-cytotoxic nature prospected for bio-imaging of bacterial cells using high-content screening analysis show that the molecule is suitable for microbial imaging in pathological diagnostic studies.

show abstract

A new pyrene based highly sensitive fluorescence probe for copper(ii) and fluoride with living cell application

Cited by 77 publications

References 47 publications

A coumarin-derived useful scaffold exhibiting Cu2+ induced fluorescence quenching and fluoride sensing (On–Off–On) via copper displacement approach

A coumarin-derived useful scaffold exhibiting Cu2+ induced fluorescence quenching and fluoride sensing (On–Off–On) via copper displacement approach

Optical sensor: a promising strategy for environmental and biomedical monitoring of ionic species

Live cell imaging of bacterial cells: Pyrenoylpyrrole‐based fluorescence labeling

Contact Info

Product

Resources

About