A new Puumala hantavirus subtype in rodents associated with an outbreak of Nephropathia epidemica in South-East Germany in 2004

Eßbauer, Sandra; Schmidt, Jonas; Conraths, Franz J.; Friedrich, R; Koch, Judith; Hautmann, W; Pfeffer, Martin; Wölfel, Roman; Finke, Jorge; Dobler, Gerhard; Ulrich, Rainer G.

doi:10.1017/s0950268806006170

Cited by 67 publications

(98 citation statements)

References 37 publications

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“…In contrast, within these particular geographic areas, only slight sequence differences were found in longitudinal analysis over several years. This conclusion is supported by the novel human Waldkirchen sequence (H72), which is almost identical to the BF strains from 2004 (6,10) and the similarity of newly derived human sequences from Munsterland (H208, H303) to the Berkel strain from 1994 (7). The molecular characterization of the viral sequences of patient and rodent origin from the outbreak areas demonstrates that PUUV is the causative agent of the current outbreak.…”

Section: Lettersmentioning

confidence: 73%

Hantavirus Outbreak, Germany, 2007

Hofmann

Meisel

Klempa

et al. 2008

Emerg. Infect. Dis.

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Section: Lettersmentioning

confidence: 73%

Hantavirus Outbreak, Germany, 2007

Hofmann

Meisel

Klempa

et al. 2008

Emerg. Infect. Dis.

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“…18 Species identification of Apodemus flavicollis and Apodemus sylvaticus was confirmed by PCR (polymerase chain reaction) targeting the mitochondrial cytochrome b gene and sequencing of PCR products. 19,20 A total of 242 animals were collected, including 131 yellow-necked mouse (A. flavicollis), 53 striped field mouse (Apodemus agrarius), three wood mouse (A. sylvaticus), 43 bank voles (Myodes glareolus), six common shrews (Sorex araneus), four common voles (Microtus arvalis), one field vole (Microtus agrestis), and one common dormouse (Muscardinus avellanarius). Animal experimentation guidelines of the American Society of Mammologists was followed during all animal work.…”

Section: Methodsmentioning

confidence: 99%

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Croatia is a focus for many rodent-borne zoonosis. Here, we report a survey of 242 rodents and small mammals, including 43 Myodes glareolus, 131 Apodemus flavicollis, 53 Apodemus agrarius, three Apodemus sylvaticus, six Sorex araneus, four Microtus arvalis, one Microtus agrestis, and one Muscardinus avellanarius, collected at eight sites in Croatia over an 8-year period. Multiplex MassTag polymerase chain reaction (PCR) was used for detection of Borrelia, Rickettsia, Bartonella, Babesia, Ehrlichia, Anaplasma, Francisella tularensis, and Coxiella burnetii. Individual PCR assays were used for detection of Leptospira, lymphocytic choriomeningitis virus, orthopoxviruses, flaviviruses, hantaviruses, and Toxoplasma gondii. Of the rodents, 52 (21.5%) were infected with Leptospira, 9 (3.7%) with Borrelia miyamotoi, 5 (2%) with Borrelia afzelii, 29 (12.0%) with Bartonella, 8 (3.3%) with Babesia microti, 2 (0.8%) with Ehrlichia, 4 (1.7%) with Anaplasma, 2 (0.8%) with F. tularensis, 43 (17.8%) with hantaviruses, and 1 (0.4%) with an orthopoxvirus. Other agents were not detected. Multiple infections were found in 32 rodents (13.2%): dual infections in 26 rodents (10.7%), triple infections in four rodents (2.9%), and quadruple infections in two rodents (0.8%). Our findings indicate that rodents in Croatia harbor a wide range of bacteria and viruses that are pathogenic to humans.

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“…5/100 000 population [19]. However, some regions in South and West Germany are known to be endemic for PUUV [2,[20][21][22][23] To investigate this outbreak we started a survey and a case-control study in May 2007. The objective of the survey was to better describe the symptoms and disease burden of PUUV infections in humans.…”

Section: Introductionmentioning

confidence: 99%

Survey and case-control study during epidemics of Puumala virus infection

et al. 2009

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SUMMARYIn Baden-Wuerttemberg, a federal state in south-west Germany, a large outbreak of 1089 laboratory-confirmed human Puumala virus (PUUV) infections occurred in 2007. We conducted a survey to describe the disease burden and a case-control study to identify risk factors for acquiring PUUV. Case-patients were interviewed about clinical outcome and both case-patients and randomly recruited controls were interviewed about exposure. We calculated matched odds ratios (mOR) using a conditional logistic regression model. Multivariable analysis of 191 matched case-control pairs showed that case-patients were more likely than controls to have seen small rodents/their droppings (mOR 1 . 9, 95 % CI 1 . 2-3 . 0), cleaned utility rooms (mOR 1 . 8, 95 % CI 1 . 0-3 . 4) and visited forest shelters (mOR 3 . 9, 95% CI 1 . 1-14 . 3). Two thirds of case-patients required hospitalization. During PUUV epidemics rodent control measures and use of protective equipment should be considered in utility rooms and shelters.

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A new Puumala hantavirus subtype in rodents associated with an outbreak of Nephropathia epidemica in South-East Germany in 2004

Cited by 67 publications

References 37 publications

Hantavirus Outbreak, Germany, 2007

Hantavirus Outbreak, Germany, 2007

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Survey and case-control study during epidemics of Puumala virus infection

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