A New Potent Antimicrobial Metalloporphyrin

Lu, Jiang; Chee, Pei Lin; Gao, Jian; Gan, C. R Raymond; Lakshminarayanan, Rajamani; Jiang, Shan; Hor, T. S. Andy; Loh, Xian Jun

doi:10.1002/asia.202100053

Cited by 4 publications

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pyrrole-containing secondary metabolites such as makaluvamine M, ryanodine, rhazinilam, lamellarin, prodigiosin, myrmicarin, and sceptrinare also exhibit potential biological activity [12][13][14][15][16][17][18][19]. Apart from this, pyrrole and pyrrolidine analogs have diverse therapeutic applications like fungicides, antibiotics, anti-inflammatory drugs, cholesterol-reducing drugs, anti-tubercular, and antitumor agents [20][21][22][23][24][25]. These are also known to inhibit reverse transcriptase in case of human immune deficiency virus type 1 (HIV-1) and cellular DNA polymerases protein kinases [26,27].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of pyrrole and pyrrolidine analogs: an update

Basha¹,

Basavarajaiah²,

Shyamsunder³

2022

Mol Divers

View full text Add to dashboard Cite

The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance . Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. Graphical Abstract

show abstract

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of pyrrole and pyrrolidine analogs: an update

Basha¹,

Basavarajaiah²,

Shyamsunder³

2022

Mol Divers

View full text Add to dashboard Cite

show abstract

Metal Complexes as Resistance Breakers or Metalloantibiotics for Combating Antimicrobial Resistance

Li¹,

Sun²

2022

Encyclopedia of Inorganic and Bioinorganic Chemistry

View full text Add to dashboard Cite

The rapid emergence and spread of antimicrobial resistant (AMR) bacterial strains post significant threats to public health globally. Owing to the complexity of AMR, different strategies have been proposed, among which metal‐based strategy has receiving growing attention. Metallodrugs/ metal‐based complexes often exert multi‐targeted mode of action, thus having less likelihood to evolve resistance. Moreover, metal complexes could also target resistant enzymes produced by bacteria, thus might serve as antibiotic adjuvants for rescuing currently used antibiotics. In this encyclopaedia, we summarize the metal‐based strategy for combating AMR including both as resistance breakers or metalloantibiotics. Their underlying mechanisms of actions are also included. We also discuss the future perspective, opportunity and challenges in the field.

show abstract