A new polyketide synthase−nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp.

Differentiated surface fungal communities at point of harvest on apple fruits from rural and peri-urban orchards

“…A total of 10 genera were enriched in rural samples, whereas a total of 5 genera were enriched in peri-urban samples. Notably, the genera enriched in rural samples were reported as protective fungi, mainly Coniothyrium 85 , Paraphaeosphaeria 68 , 81 , Periconia 86 and Sclerostagonospora 87 . The genus Coniothyrium might have the ability to control fruit disease.…”

“…For example, the Coniothyrium minitans species has been widely reported as a bio-control agent against the plant-pathogenic fungus Sclerotinia sclerotiorum 88 . Genera of Paraphaeosphaeria 68 , Periconia 86 and Sclerostagonospora 87 have been reported to be endophytic fungi. Entyloma 56 and Phoma 60 (enriched rural samples) have been reported to show pathogenic features .…”

Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes

“…from the medicinal plant Annona muricata , and discovered it was cytotoxic to several human cancer cell lines. Bioassay-guided isolation of EtOAc extracts of the different fermentation media of this strain resulted in the isolation and identification of twelve novel PKS-NRPS hybrid cytochalasans [ 120 , 121 , 122 , 123 , 124 ]. Among them, periconiasins A and B ( 92 and 93 , Figure 16 ) with an unprecedented 9/6/5 tricyclic ring system exhibited significant cytotoxicity against human HCT-8 cancer cells with IC 50 values of 0.9 and 0.8 μM, respectively [ 123 ].…”

“…Periconiasin D ( 94 , Figure 16 ) has a 5/6/6/5 tetracyclic ring skeleton, while periconiasin G ( 95 , Figure 16 ) is the first cytotoxic cytochalasan with a 7/6/5 tricyclic ring system [ 120 ]. Pericoannosin A ( 96 , Figure 16 ) possesses an unusual hexahydro-1 H -isochromen-5-isobutylpyrrolidin-2-one skeleton and showed moderate anti-HIV activity (IC 50 of 69.6 μM) [ 122 , 124 ]. Compounds 92 – 96 were proposed to be biosynthesized from an unusual seven acetate/malonate polyketide chain attached to a leucine unit by a PKS-NRPS and a key Diels-Alder reaction should be occurred in the cyclization of cytochalasans [ 122 , 123 ].…”

Phenolic Compounds from Endophytic Pseudofusicoccum sp. Isolated from Annona muricata

“…A. muricata have been studied for the bioactive natural products produced by its endophytic fungal populations. [14][15][16][17][18][19][20][21][22][23] 14,15,17 and sesquiterpenes: periconianones C-K. 19 Secondary metabolites of endophytic fungi of A. muricata showed anticancer activities. 22,23 Periconiasins A and B showed significant cytotoxicity against human colon cancer cells (HCT-8).…”