A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity

Luyen, Bui Thi Thuy; Tài, Bùi Hữu; Thao, Nguyen Phuong; Yang, Seo Young; Cuong, Nguyen Manh; Kwon, Young-In; Jang, Hae‐Dong; Kim, Young Ho

doi:10.1016/j.bmcl.2014.07.057

Cited by 32 publications

(25 citation statements)

References 23 publications

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“…In this study, the total phenolic content of Piper retrofractum extract was approximately about 0.98 mg GAE/g. Piper retrofractum extracts also contain piperidine alkaloids [24], phenylpropanoids [29], and amides [25] that can act as capping agents in the formation of CuNPs. The illustration picture for the formation of CuNPs using Piper retrofractum fruit extract is given in Figure 2.…”

Section: Synthesis and Mechanism Of Cunps Formationmentioning

confidence: 99%

“…The phytochemical test of Piper retrofractum extract shows the presence of flavonoid, alkaloid, tannin, and steroid/terpenoid compound groups [28]. In addition, several studies have shown that the primary and secondary metabolite compounds in Piper retrofractum include piperidine alkaloids [24], phenylpropanoids [29], and amides [25]. So far, the previous study had shown 33 compounds successfully isolated from this plant [25].…”

Section: Introductionmentioning

confidence: 97%

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Green synthesis and characterization of copper nanoparticles using Piper retrofractum Vahl extract as bioreductor and capping agent

Amaliyah

Pangesti

Masruri

et al. 2020

Heliyon

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The copper nanoparticles (CuNPs) have attracted much attention due to their application in diverse fields. The applications of CuNPs depend on their physical and chemical properties. This study presents the first report for the use of medicinal fruit extract of Piper retrofractum Vahl as an eco-friendly reagent in the synthesis of CuNPs using copper sulfate as a starting material. Piper retrofractum Vahl extract was employed as a bioreductor as well as a capping agent in the formation of CuNPs. The reaction process was assisted by sonication and stirring. The influences of extract concentration, pH, temperature, and reaction time on the size of CuNPs were studied in detail. The morphology and structure of synthesized CuNPs were characterized by UV-Vis, FT-IR, SEM-EDS, TEM, and XRD. The UV-Vis measurement showed the surface plasmon resonance (SPR) peak at 234-255 nm, whereas FTIR characteristic peaks of metal-oxygen (Cu-O) were confirmed in the range 550-570 cm À1 and Cu-O-H bonds led to bending absorptions in the region 870-880 cm À1. The synthesized CuNPs possess the spherical shapes and high content of copper (70.3%) as confirmed by SEM-EDS. From the TEM micrograph, it can be seen that the particle size distribution of CuNPs has a high uniformity with a size of 2-10 nm under the optimum condition. The crystalline nature of CuNPs as confirmed by XRD showed the crystallinity phase of 26.4%. The synthesized CuNPs have relatively good stability and could inhibit Escherichia coli and Staphylococcus aureus. The results proved that Piper retrofractum Vahl fruit extract could be applied for a greener synthesis of CuNPs with high uniformity of particle sizes.

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Section: Synthesis and Mechanism Of Cunps Formationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Green synthesis and characterization of copper nanoparticles using Piper retrofractum Vahl extract as bioreductor and capping agent

Amaliyah

Pangesti

Masruri

et al. 2020

Heliyon

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“…Dried hihatsumodoki fruits are traditionally used as a seasoning, which has a unique pungent taste and aroma, and for various therapeutic purposes. The pepper fruits contain medicinal components, including the main pungent alkaloid piperine and other phenolic compounds (Luyen et al, ). These compounds exhibit anti‐obesity (Kim, Lee, Jo, & Hwang, ), hepatoprotective (Matsuda et al, ), and antioxidative effects (Chonpathompikunlert, Wattanathorn, & Muchimapura, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of solar‐ and oven‐drying on physicochemical and antioxidant characteristics of hihatsumodoki ( Piper retrofractum Vahl) fruit

Takahashi

Ohshiro

Ohno

et al. 2017

J Food Process Preserv

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The physicochemical and antioxidant properties of whole hihatsumodoki (Piper retrofractum Vahl) pepper fruits were evaluated before and after solar‐ and oven‐drying. Desirable dry matter (24% relative mass) and aw (0.50) values were obtained after solar‐drying for 18 hr, and oven‐drying for 24, 6, and 4 hr at 50, 70, and 90 °C, respectively. The color parameters (Hunter a* and b* values) of the fruits were affected by their drying conditions. Principal component analysis was used to determine suitable drying conditions to obtain dried pepper fruits with desirable food and color properties. The piperine contents of the dried pepper fruits were maintained under all of the drying conditions tested. However, solar‐drying for 18 hr and oven‐drying at 90 °C for 6 hr resulted in significant reductions in their total phenol contents and DPPH radical scavenging activities. The results of this study may be useful for optimizing the drying of whole hihatsumodoki fruits. Practical applications This work aimed to study the effects of solar‐ and oven‐drying processes on the physicochemical properties of an economically important species of pepper fruits, hihatsumodoki. A range of drying conditions was examined, and the optimal conditions were determined to maintain pungency and antioxidant activity while achieving a sufficiently low water activity to prevent microbial growth and spoilage. The present study serves as an important work in providing insights into how the thermal and UV stabilities of piperine and phenolic compounds in hihatsumodoki pepper fruits affect the physicochemical and antioxidant properties when the fruits are subjected to different drying conditions. The work described in this paper will be of use to a wide range of readers interested in optimizing drying processes based on experimental data, and may be applicable to a variety of Piperaceae.

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“…Except for M. siamensis , all medicinal plants have been recorded to possess notable antioxidant capacity. Previous studies demonstrated that piperoside isolated from P. retrofractum exhibited moderate peroxyl radical scavenging and reducing potential activity [ 32 ], while Terminalia citrina was found to display protective effects against oxidant-induced Heinz body formation [ 33 ], which contributes to anaemia. Reported active constituents, including total oligomeric flavonoid fractions, nootkatone, aristolone, solavetivone, and orientin obtained from Cyperus rotundus , have protective effects against lipid peroxidation, DNA damage, antihemolytic activity, and anticancer treatment for erythroleukaemia cells, which might be correlated with their high antioxidant activities [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant capacities and total phenolic contents of 20 polyherbal remedies used as tonics by folk healers in Phatthalung and Songkhla provinces, Thailand

Chanthasri

Puangkeaw

Kunworarath

et al. 2018

BMC Complement Altern Med

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BackgroundUses of polyherbal formulations have played a major role in traditional medicine. The present study is focused on the formulations used in traditional Thai folkloric medicine as tonics or bracers. Twenty documented polyherbal mixtures, used as nourishing tonics by the folk healers in Phatthalung and Songkhla provinces in southern Thailand, are targeted. Despite traditional health claims, there is no scientific evidence to support the utilization of polyherbal formulations.MethodsThe phenolic and flavonoid contents of the polyherbal formulations and a series of antioxidant tests were applied to measure their capability as preventive or chain-breaking antioxidants. In addition, the cytotoxic activity of effective formulations was assayed in Vero cells.ResultsNinety-eight plant species belonging to 45 families were used to prepare the tested formulation. The preliminary results revealed that water extracts of THP-R016 and THP-R019 contain a high level of total phenolic and flavonoid contents and exhibit remarkable antioxidant activities, as tested by DPPH, ABTS, and FRAP assays. The extract of THP-R019 also showed the strongest metal chelating activities, whereas THP-R016 extract possessed notable superoxide anion and peroxyl radical scavenging abilities.ConclusionsThe data provide evidence that the water extracts of folkloric polyherbal formulations, particularly THP-R016, are a potential source of natural antioxidants, which will be valuable in the pharmaceutical and nutraceutical industries. The free radical scavenging of THP-R016 may be due to the contribution of phenolic and flavonoid contents. Useful characteristics for the consumer, such as the phytochemical profiles of active ingredients, cellular based antioxidant properties and beneficial effects in vivo, are under further investigation.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2131-y) contains supplementary material, which is available to authorized users.

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A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity

Cited by 32 publications

References 23 publications

Green synthesis and characterization of copper nanoparticles using Piper retrofractum Vahl extract as bioreductor and capping agent

Green synthesis and characterization of copper nanoparticles using Piper retrofractum Vahl extract as bioreductor and capping agent

Effects of solar‐ and oven‐drying on physicochemical and antioxidant characteristics of hihatsumodoki ( Piper retrofractum Vahl) fruit

Antioxidant capacities and total phenolic contents of 20 polyherbal remedies used as tonics by folk healers in Phatthalung and Songkhla provinces, Thailand

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