A new perspective in Oral health: Potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity

Cutando, Antonio; Aneiros‐Fernández, José; López-Valverde, Antonio; Arias‐Santiago, Salvador; Aneiros-Cachaza, José; Reíter, Russel J.

doi:10.1016/j.archoralbio.2011.03.004

Cited by 63 publications

(45 citation statements)

References 97 publications

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“…Other actions, such as immunomodulatory and protective functions (Cutando et al 2003;Carrillo-Vico et al 2005;Konturek et al 2007), are regulated by its interaction with retinoid orphan receptors/retinoid Z receptors (RZR⁄ROR), a family of nuclear receptors (Cutando et al 2011). Most of the biological functions of melatonin are thought to be mediated by the membrane receptors, melatonin 1 (MT1) and 2 (MT2).…”

Section: Introductionmentioning

confidence: 99%

Subcellular distribution of melatonin receptors in human parotid glands

et al. 2013

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The hormone melatonin influences oral health through a variety of actions, such as anti-inflammatory, antioxidant, immunomodulatory and antitumour. Many of these melatonin functions are mediated by a family of membrane receptors expressed in the oral epithelium and salivary glands. Using immunoblotting and immunohistochemistry, recent studies have shown that the melatonin membrane receptors, MT1 and MT2, are present in rat and human salivary glands. To date, no investigation has dealt with the ultrastructural distribution of the melatonin receptors. This was the aim of the present study, using the immunogold method applied to the human parotid gland. Reactivity to MT1 and, with less intensity, to MT2 appeared in the secretory granules of acinar cells and in the cytoplasmic vesicles of both acinar and ductal cells. Plasma membranes were also stained, albeit slightly. The peculiar intracytoplasmic distribution of these receptors may indicate that there is an uptake/transport system for melatonin from the circulation into the saliva.

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Section: Introductionmentioning

confidence: 99%

Subcellular distribution of melatonin receptors in human parotid glands

et al. 2013

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“…Once synthesized, the majority of melatonin diffuses directly towards the cerebrospinal fluid of the brain's third ventricle, while another fraction is released into the blood stream where it is distributed to all tissues and body fluids (Cheung et al 2006). It is found in serum, saliva (Cutando et al 2011, Novakova et al 2011, cerebrospinal fluids (Rousseau et al 1999), and aqueous humor of the eye (Chiquet et al 2006), ovarian follicular fluid, hepatogastrointestinal tissues (Messner et al 2001). Melatonin in the milk of lactating mothers exhibits a marked daily rhythm, with high levels during the night and undetectable levels during the day (Illnerova et al 1993, Sanchez-Barcelo et al 2011.…”

Section: Synthesis Distribution and Metabolismmentioning

confidence: 99%

“…RZR/ROR family is expressed in a variety of organs. It presumably regulates the immune system and circadian cycles via the nuclear receptor and these also may be involved in its regulation of antioxidative enzymes (Cutando et al 2011). …”

Section: Synthesis Distribution and Metabolismmentioning

confidence: 99%

Melatonin for Protection Against Ionizing Radiation

El-Missiry¹,

Othman²,

Al-Abdan³

2012

Current Topics in Ionizing Radiation Research

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“…MT 1 and MT 2 are membrane, G protein coupled, receptors specific to melatonin, whereas MT 3 and retinoic acid receptor-related orphan receptor α (RORA) are cytosolic molecules with a wide specificity to agonists [18]. Initiation of MT 1 and MT 2 is necessary for sleep promotion; initiation of those receptors leads to inhibition of neuronal activity and phase shift circadian firing rhythms in the suprachiasmatic nucleus [19].…”

Section: Melatonin Interaction With Receptor Moleculesmentioning

confidence: 99%

Impact of melatonin on immunity: a review

Pohanka

2013

Open Medicine

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AbstractMelatonin is a hormone produced by the pineal gland. In addition to its hormonal effect, it has strong antioxidant properties. Melatonin is probably best known for its ability to control circadian rhythm; it is sold in many countries as a supplement or drug for improving of sleep quality. However, melatonin’s effect is not limited to control of circadian rhythm:. it is involved in other effects, including cell cycle control and regulation of several important enzymes, including inhibition of inducible nitric oxide synthase. Melatonin affects immunity as well. It can modulate the immune response on disparate levels with a significant effect on inflammation. The role of melatonin in body regulatory process is not well understood; only limited conclusions can be drawn from known data. The current review attempts to summarize both basic facts about melatonin’s effects and propose research on the lesser known issues in the future.

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A new perspective in Oral health: Potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity

Cited by 63 publications

References 97 publications

Subcellular distribution of melatonin receptors in human parotid glands

Subcellular distribution of melatonin receptors in human parotid glands

Melatonin for Protection Against Ionizing Radiation

Impact of melatonin on immunity: a review

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