Impact of melatonin on immunity: a review

Pohanka, Miroslav

doi:10.2478/s11536-013-0177-2

Cited by 24 publications

(25 citation statements)

References 70 publications

(78 reference statements)

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“…Experimental rheumatoid arthritis is a typical consequence of an uncontrolled infl ammation initiated by FCA (16). Infl ammation is in a tight link to oxidative stress as a causative process and to depletion of low molecular weight antioxidants as well (17,18). In the results part, we showed both induction of infl ammation because of the TNF α level increase and oxidative stress arising because of the signifi cant augmentation of TBARS value representing malondialdehyde in both the liver and muscle tissue.…”

Section: Discussionmentioning

confidence: 58%

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Pohanka¹,

Vobornikova²,

Fusek³

2016

BLL

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Freund´s complete adjuvant (FCA) is a mean used for improving immunization effi cacy in experiments and veterinary medicine. Despite high effi cacy, it is not used in human vaccination due to number of adverse effects. Arthritis can be an example of a typical adverse consequence. In this work, we decided to investigate the link between oxidative stress and infl ammation in animals exposed to FCA. BALB/c mice received either saline or FCA in doses 10-50 μl and were euthanized from one to three days after infection. Interleukins (IL) IL-2, IL-4 and tumor necrosis factor α (TNF-α) were determined in plasma. Ferric reducing antioxidant power (FRAP), malondialdehyde by thiobarbituric acid reactive substances assay (TBARS), reduced glutathione (GSH) and caspase-3 were measured in livers, muscles and other organs. We determined signifi cant effect of FCA on TBARS and GSH in the livers. Beside this, TBARS were altered in muscles as well. Infl ammation was confi rmed by increased level of TNF-α. Taking the results into account, we infer that the harmful effect of FCA is mediated not only by infl ammation but also by oxidative. This should be considered when pathological consequences of FCA are scored (Fig. 4, Ref. 21). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 58%

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Pohanka¹,

Vobornikova²,

Fusek³

2016

BLL

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“…The link between circulating melatonin and immune function is rarely highlighted in any species other than vertebrates, and how melatonin modulates immune response remains a subject of debate [72,73,90]. The fact that crickets maintained on the 0 mg ml 21 melatonin treatment had comparable haemocyte concentrations and lysozyme-like activity across the majority of their adult lifespan supports previous findings that adult Teleogryllus commodus maintained under intense constant illumination may have compromised immunity and be less able to respond to immune challenges (J Durrant, EB Michaelides, MP Green and TM Jones 2013, unpublished data; see §1).…”

Section: Discussionmentioning

confidence: 99%

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

Jones

Durrant

Michaelides

et al. 2015

Phil. Trans. R. Soc. B

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The mechanisms underpinning the ecological impacts of the presence of artificial night lighting remain elusive. One suspected underlying cause is that the presence of light at night (LAN) supresses nocturnal production of melatonin, a key driver of biological rhythm and a potent antioxidant with a proposed role in immune function. Here, we briefly review the evidence for melatonin as the link between LAN and changes in behaviour and physiology. We then present preliminary data supporting the potential for melatonin to act as a recovery agent mitigating the negative effects of LAN in an invertebrate. Adult crickets ( Teleogryllus commodus ), exposed to constant illumination, were provided with dietary melatonin (concentrations: 0, 10 or 100 µg ml −1 ) in their drinking water. We then compared survival, lifetime fecundity and, over a 4-week period, immune function (haemocyte concentration, lysozyme-like and phenoloxidase (PO) activity). Melatonin supplementation was able only partially to mitigate the detrimental effects of LAN: it did not improve survival or fecundity or PO activity, but it had a largely dose-dependent positive effect on haemocyte concentration and lysozyme-like activity. We discuss the implications of these relationships, as well as the usefulness of invertebrates as model species for future studies that explore the effects of LAN.

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“…Melatonin ( N ‐acetyl‐5‐methoxy tryptamine) is a hormone that influences circadian and seasonal rhythms; however, melatonin is also a powerful antioxidant, metal chelator, and anti‐inflammatory agent . Melatonin secretion modulates the production of the thyrotropin and tuberalin hormone and induces synthesis of triiodothyronine (T3).…”

Section: Neuro‐immuno‐endocrinological Approachmentioning

confidence: 99%

Biological hypotheses and biomarkers of bipolar disorder

Sigitova

Fišar

Hroudová

et al. 2017

Psychiatry Clin Neurosci

182

117

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The most common mood disorders are major depressive disorders and bipolar disorders (BD). The pathophysiology of BD is complex, multifactorial, and not fully understood. Creation of new hypotheses in the field gives impetus for studies and for finding new biomarkers for BD. Conversely, new biomarkers facilitate not only diagnosis of a disorder and monitoring of biological effects of treatment, but also formulation of new hypotheses about the causes and pathophysiology of the BD. BD is characterized by multiple associations between disturbed brain development, neuroplasticity, and chronobiology, caused by: genetic and environmental factors; defects in apoptotic, immune-inflammatory, neurotransmitter, neurotrophin, and calcium-signaling pathways; oxidative and nitrosative stress; cellular bioenergetics; and membrane or vesicular transport. Current biological hypotheses of BD are summarized, including related pathophysiological processes and key biomarkers, which have been associated with changes in genetics, systems of neurotransmitter and neurotrophic factors, neuroinflammation, autoimmunity, cytokines, stress axis activity, chronobiology, oxidative stress, and mitochondrial dysfunctions. Here we also discuss the therapeutic hypotheses and mechanisms of the switch between depressive and manic state.

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Impact of melatonin on immunity: a review

Cited by 24 publications

References 70 publications

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

Biological hypotheses and biomarkers of bipolar disorder

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