The current study was a prospective exploration of the specificity of early childhood adversities as predictors of anxiety and depressive disorders in adolescents. Participants were 816 adolescents (414 males, 402 females) with diagnostic information collected at age 15; information on early adversities had been collected from the mothers during pregnancy, at birth, age 6 months, and age 5 years for a related study. Adolescents with "pure" anxiety disorders were compared with adolescents with "pure" depressive disorders (major depressive disorder, dysthymia), and these groups were compared to never-ill controls. Analyses controlled for gender and maternal depression and anxiety disorders. Results indicated that adolescents with anxiety disorders were more likely than depressed youth to have been exposed to various early stressors, such as maternal prenatal stress, multiple maternal partner changes, and more total adversities, whereas few early childhood variables predicted depressive disorders. Even when current family stressors at age 15 were controlled, early adversity variables again significantly predicted anxiety disorders. Results suggest that anxiety disorders may be more strongly related to early stress exposure, while depressive disorders may be related to more proximal stressors or to early stressors not assessed in the current study.KEY WORDS: depression; anxiety; early adversity; longitudinal. Kessler and Magee (1993) investigated the power of retrospectively reported childhood adversities occurring through age 16 to predict depression in an epidemiological sample. Eight adversities were studied, and many were found to be associated with incidence and prevalence of major depressive disorder. Parental drinking, parental mental illness, violence in the family, parents' marital problems, death of mother or father, and absence of a close adult relationship in childhood were significantly associated with onset of depression by age 20. These results are consistent with psychological models of depression that commonly emphasize the influence of negative childhood experiences in the family affecting the qual-