A New Pentacyclic Triterpene from Abutilon pakistanicum

Ahmed, Zaheer; Kazmi, Syed Najam-ul-Hussain; Malik, Abdul

doi:10.1021/np50071a032

Cited by 19 publications

(11 citation statements)

References 8 publications

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“…Previous phytochemical studies on species from Malvaceae, specially of the genus Sida have reported the presence of steroids, [5][6][7][8] phenols, 6,7,9 flavonoids, [6][7][8]10,11 triterpenes, 5,9 essential oils, 12 alkaloids, 13 sesquiterpene lactone, 14 fatty acids, 15 and phaeophorbide. 6 Aiming at contributing to the chemotaxonomic study of the family Malvaceae, subfamily Malvoideae, and considering the absence of data in literature concerning the chemical constitution of the genus Sidastrum, the species Sidastrum paniculatum was submitted to a phytochemical study to isolate and identify its chemical constituents, through usual chromatographic and spectroscopic methods, besides comparison with literature data.…”

Section: Introductionmentioning

confidence: 99%

Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

et al. 2010

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Recebido em 28/5/09; aceito em 17/11/09; publicado na web em 2/3/10Sidastrum paniculatum (L.) Fryxell belongs to the family Malvaceae and is popularly known as "malva roxa" or "malvavisco". The phytochemical study of the hexane, CHCl 3 and EtOAc phases from the crude ethanol extract of S. paniculatum led to the isolation of six compounds: a mixture of b-sitosterol and stigmasterol, 4-methoxy-3-hydroxybenzoic acid, 4-methoxy-3-hydroxybenzaldehyde, N-trans-feruloyltyramine and kaempferol-3-O-b-D-(6''-E-p-coumaroyl) glucoside. The structural identification of the compounds was made on the basis of spectroscopic methods such as IR, 1 H and 13 C NMR with the aid of including two-dimensional techniques, besides comparison with literature data. The b-sitosterol and stigmasterol mixture showed a significant anti-inflammatory activity.

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Section: Introductionmentioning

confidence: 99%

Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

et al. 2010

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“…Some of these uses include snakebites, 3 asthma, 4 diuretic, in treatment of rheumatism and gastrointestinal disorders, 5,6 among others. Chemical studies about the secondary metabolites from Malvaceae have described the occurrence of triterpenes, 7 flavonoids, 8,9 essential oils, 10 sesquiterpenelactones 11 and fatty acids. [12][13][14][15] The genus Herissantia is constituted by six species, found in the tropical America, particularly in Antilles, Mexico and South America.…”

Section: Introductionmentioning

confidence: 99%

First secondary metabolites from Herissantia crispa L (Brizicky) and the toxicity activity against Artemia salina Leach

Costa¹,

Matias²,

Lima³

et al. 2009

Quím. Nova

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First secondary metabolites From -β-D-glucopyranoside, 3,5,7,4'-tetrahydroxyflavone (kaempferol), 3,5,7,3',4'-pentahydroxyflavone (quercetin), unpublished in the genus Herissantia, besides β-sitosterol, kaempferol 3-O-β-D-(6''-Ep-coumaroil) (tiliroside) glucopyranoside and kaempferol 3,7-di-O-α-L-ramnopyranoside (lespedin), described for the first time in the species. The structural determination of the compounds was made by means of spectroscopy methods such as Infrared Spectroscopy, 1 H and 13 C Nuclear Magnetic Resonance, with the aid of two dimensional techniques, and by comparison with literature data. The toxicity activity of the MeOH extract and lespedin on Artemia salina Leach. was also carried out.

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“…Fraction A was applied to a silica gel CC eluted with a gradient of MeOH:H 2 O (15:100) to afford 30 subfraction (each 20 ml). Sub fraction [6][7][8][9][10][11][12][13][14] 3 :MeOH with increasing contents of methanol afforded compound 8 (45 mg) and 9 (32 mg). Fraction E was subjected to CC over silica gel using gradient elution with C 6 H 6 :EtOAc (10:0-3:7) afforded 24 subfraction (each 15 ml) possess mixture of compounds; subfraction [2][3][4][5][6][7][8][9] subjected to a preparative silica gel chromatography afforded compound 3 (27 mg), then subfractions [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] was re-purified on Sephadex LH-20 CC and eluted with MeOH:H 2 O (9.5:0.5) affording compound 10 (36 mg).…”

Section: Extraction and Isolationmentioning

confidence: 99%

“…The flowers and leaves of some Abutilon species are applied as antiseptic and anti-inflammatory for urethritis, boils, and ulcers [6]. Several Abutilon species have been reported to consist of several constituents such as triterpenes, sterols [7], sesquiterpene lactones [8], flavonoids [9], phenolic acids [10], and essential oil [11]. The leaf extract of Abutilon indicum has been reported for the hepatoprotective activity [12].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Bioactivity and Antioxidative Properties of Some Compounds Isolated From Abutilon Hirtum (Lam.)

Hamed¹,

Refahy²,

Abdel‐Aziz³

2017

Asian J Pharm Clin Res

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Objectives: The present study on the methanol extract of Abutilon hirtum (Lam.) [Malvaceae] afforded ten compounds. Findings from this assessment indicated that A. hirtum leaves possessed vast potential as medicinal product especially in liver cancer treatment.Methods: Dried-powdered leaves were boiled under reflux in 10 L of petroleum ether for 8 hrs. After filtration, the solvent was evaporated; afforded 15 g of petroleum ether extract followed by boiling with reflux for 8 hrs with chloroform, then filtration and the residue was evaporated to give 34 g chloroform extract. Ethyl acetate was added and refluxed for 8 hrs, then filtration and evaporation to give 31 g ethyl acetate extract. Finally the leaves were refluxed with 10 L of 85 % aqueous MeOH, after cooling, the solution was filtered and evaporated and the residue was 210 g methanol extract then the residue was dissolved in de-ionized water (250 ml), then the salt was removed by adding excess methanol solution (2.5 L), and finally filtered. The cytotoxicity of the isolated compounds was evaluated towards HepG2 liver-carcinoma cell line using MTT assay, the antimicrobial activity was tested using the Disc agar plate method and the total antioxidant capacity was determined according to phosphomolybdenum method. Results:The isolated compounds identified as methyl gallate, cuneataside E, bergapten, gallic acid, ellagic acid, epigallocatechin-3-O-gallate, kaempferol-3-O-α-L-rhamnoside, benzyl-1-O-β-D-glucopyranoside, 2(4-hydroxyphenyl)ethyl-O-β-D-glucopyranoside and β-sitosterol. All the isolated compounds are known; but they were isolated from Abutilon hirtum for the first time. Conclusion:This report may serve as a footprint concerning the biological and pharmacological activities of A. hirtum leaves.

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A New Pentacyclic Triterpene from Abutilon pakistanicum

Abstract: A new ursene type triterpene, pakistanol [1], was isolated from Abutilón pakistanicum. Its structure has been assigned as urs-12(13)-en-24|i-ol on the basis of chemical and spectral studies. Taraxasterol, ß-sitosterol, and a-amytin were also isolated.

Cited by 19 publications

References 8 publications

Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

First secondary metabolites from Herissantia crispa L (Brizicky) and the toxicity activity against Artemia salina Leach

Assessing the Bioactivity and Antioxidative Properties of Some Compounds Isolated From Abutilon Hirtum (Lam.)

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