A new outside stent – does it prevent vein graft intimal proliferation?

Abstract

The external vein graft support with mesh tubing reduces intimal and medial layer thickening and cell proliferation in composite vein grafts transplanted in the arterial position.

Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease

“…This step was followed by incubation with biotinylated secondary antibody, and final visualization was achieved by using the avidin-biotin complex peroxidase kit (Vector Laboratories, Burlingame, CA), freshly prepared 3,3Ј-diaminobenzidine tetrahydrochloride, and hydrogen peroxide according to the protocol provided by the manufacturer. Normal rabbit serum instead of anti-B2R or anti-B2R antibodies was used as a control (9,21).…”

Flow patterns in externally stented saphenous vein grafts and development of intimal hyperplasia

“…Mechanical external stents for SVGs have shown significant reductions of proliferative intimal hyperplasia, foam cells deposition, and other vascular disease markers in pre-clinical testing (10)(11)(12)(13). This protective effect of external stents is attributed to the reduction in SVG wall tension, the improvement of lumen uniformity and the formation of a "neo-adventitia" layer rich with micro vasculature (10)(11)(12)(13)(14).…”

“…This protective effect of external stents is attributed to the reduction in SVG wall tension, the improvement of lumen uniformity and the formation of a "neo-adventitia" layer rich with micro vasculature (10)(11)(12)(13)(14). The VEST (Vascular Graft Solutions Ltd, Tel Aviv, Israel) is a kink resistant cobalt-chromium braided mesh, applied externally to the vein graft during surgery.…”

Knitted nitinol represents a new generation of constrictive external vein graft meshes

“…13 Apart from mitigating neointimal tissue formation, they protected the vein grafts against compression and deformation. 14 Our own group used metal meshes to demonstrate that to achieve optimal suppression of diffuse IH, 7 the degree of overall constriction needs to aim at a diameter match of vein graft and host artery. 8 Furthermore, by introducing the superelastic shape memory alloy nitinol as a mesh material, persistent longitudinal pleating of braided meshes became possible, thereby allowing the extreme constriction of vein grafts without the occurrence of wall folding.…”