Knitted nitinol represents a new generation of constrictive external vein graft meshes

Zilla, Peter; Moodley, Loven; Wolf, Michael; Bezuidenhout, Deon; Sirry, Mazin S.; Rafiee, Nasser; Lichtenberg, Wilhelm; Black, Melanie; Franz, Thomas

doi:10.1016/j.jvs.2011.05.023

Cited by 34 publications

(36 citation statements)

References 21 publications

(41 reference statements)

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“…Additionally, the authors demonstrated that only in the 50% constricted vein graft was endothelialization maintained (Zilla et al, 2008). Although the authors demonstrated some pulse compliance in a subsequent knitted nitinol wire mesh study, wire breakage and www.frontiersin.org a lower degree of surface endothelialization was observed (Zilla et al, 2011).…”

Section: Autologous Graftsmentioning

confidence: 97%

“…Despite the decreased intimal hyperplasia observed with the supported vein grafts, the wire mesh supports are not biodegradable and thus, introduce the risk of future complications (Vijayan et al, 2004) should the wire supports fray, break, or undergo radial narrowing from axial distension (Zilla et al, 2008(Zilla et al, , 2011. Vijayan et al examined a polyglactin biodegradable external sheath as support for porcine saphenous vein grafts to prevent future risks from permanent stents.…”

Section: Autologous Graftsmentioning

confidence: 99%

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Vascular Grafting Strategies in Coronary Intervention

2014

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With the growing need for coronary revascularizations globally, several strategies to restore blood flow to the heart have been explored. Bypassing the atherosclerotic coronary arteries with autologous grafts, synthetic prostheses, and tissue-engineered vascular grafts continue to be evaluated in search of a readily available vascular graft with clinically acceptable outcomes. The development of such a vascular graft including tissue engineering approaches both in situ and in vitro is herein reviewed, facilitating a detailed comparison on the role of seeded cells in vascular graft patency.

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Section: Autologous Graftsmentioning

confidence: 97%

Section: Autologous Graftsmentioning

confidence: 99%

Vascular Grafting Strategies in Coronary Intervention

2014

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“…[20][21][22][23] Recently, perivenous mesh was proposed as a promising structural design following extensive evaluations. [16][17][18]33,34 The optimal balance between ultrastructural porosity and mechanical resistance of meshes requires further investigation. A pioneer study by van der Merwe and colleagues 35 has provided a numerical approach to optimization of constrictive knitted meshes.…”

Section: Ultrastructure Of External Supporting Materialsmentioning

confidence: 99%

“…Type of external support Animal model Result Barra 12 Constrictive (low Qc) Dacron mesh Sheep carotid artery interposition graft Positive EI-Kurdi 15 Microfibrillar polymer Porcine carotid artery interposition graft Positive Zilla 16,18,34 Nitinol mesh Chasma baboon femoral artery interposition graft Positive Lardenoye 24 Polyethylene Transgenic mouse carotid artery interposition graft Positive Izzat 31 Constrictive (high Qc) Polypropylene Porcine: carotid artery interposition graft Negative Mehta 6 Loose-fitting (high Qc) Polyester Porcine carotid artery interposition graft Positive Vijavan 19 Polyglactin Porcine carotid artery interposition graft Positive George 20 Polyester and PTFE Porcine carotid artery interposition graft Positive Jeremy 21,22 Polyester and polyglactin Porcine carotid artery interposition graft Positive Izzat 31 Polypropylene Porcine carotid artery interposition graft Positive Angelini 23 Polyester Porcine carotid artery interposition graft Positive You 32 Polydioxan Rabbit carotid artery interposition graft Positive Qc: quotient of cross-sectional areas of the recipient arteries to in situ (pre-harvest) vein grafts.…”

Section: Authormentioning

confidence: 99%

External support in preventing vein graft failure

Wan

2012

Asian Cardiovasc Thorac Ann

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Saphenous vein remains a widely used conduit in coronary surgery. However, the long-term success of surgical myocardial revascularization is largely limited by the development of neointimal hyperplasia and superimposed atherosclerosis in vein grafts. Although strategies for preventing vein graft failure have been constantly explored, few therapeutic interventions to date have shown sustained benefits in the clinical setting. The application of external support has emerged as a promising strategy for modulating the overall biomechanical responses in venous wall. Nonetheless, clinical translation of this intervention has been formerly challenged, primarily due to several technique limitations. The purpose of the current review is to summarize the possible mechanisms involved in the external support strategy for preventing vein graft failure. Furthermore, several previously tested biomaterials and delivery techniques are also highlighted.

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“…Knit structures are flexible and highly porous and have an inherent ability to resist unraveling when cut. Due to the high level of conformability and porosity, knitted fabrics are ideal candidates for vascular implants 37 . Other applications include aortic valves, 38 tracheal cartilage reconstruction 39 and ligament reconstruction 40 .…”

Section: Introduction: Techniques For Preparation Of Porous Structurementioning

confidence: 99%

Highly porous drug-eluting structures

et al. 2012

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For many biomedical applications, there is need for porous implant materials. The current article focuses on a method for preparation of drug-eluting porous structures for various biomedical applications, based on freeze drying of inverted emulsions. This fabrication process enables the incorporation of any drug, to obtain an “active implant” that releases drugs to the surrounding tissue in a controlled desired manner. Examples for porous implants based on this technique are antibiotic-eluting mesh/matrix structures used for wound healing applications, antiproliferative drug-eluting composite fibers for stent applications and local cancer treatment, and protein-eluting films for tissue regeneration applications. In the current review we focus on these systems. We show that the release profiles of both types of drugs, water-soluble and water-insoluble, are affected by the emulsion's formulation parameters. The former's release profile is affected mainly through the emulsion stability and the resulting porous microstructure, whereas the latter's release mechanism occurs via water uptake and degradation of the host polymer. Hence, appropriate selection of the formulation parameters enables to obtain desired controllable release profile of any bioactive agent, water-soluble or water-insoluble, and also fit its physical properties to the application.

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Knitted nitinol represents a new generation of constrictive external vein graft meshes

Abstract: Combining the suppression of intimal hyperplasia with a more physiologic remodeling process of the media, manifold higher kink-resistance, and lower fraying than in braided meshes makes knitted nitinol an attractive concept in external vein graft protection.

Cited by 34 publications

References 21 publications

Vascular Grafting Strategies in Coronary Intervention

Vascular Grafting Strategies in Coronary Intervention

External support in preventing vein graft failure

Highly porous drug-eluting structures

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