A new oleanane glycoside from the roots of <i>Astragalus caprinus</i>

Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Semmar, Nasredine; Jay, Maurice; Lacaille‐Dubois, Marie‐Aleth

doi:10.1002/mrc.1809

Cited by 16 publications

(19 citation statements)

References 9 publications

(8 reference statements)

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“…For 1D and 2D NMR spectra ( 1 H-1 H COSY, TOCSY, NOESY, HSQC, and HMBC), see Mitaine-Offer et al (2006). HRESIMS (positive-ion mode) was carried out on a Q-TOF 1-micromass spectrometer, and FABMS (negative-ion mode, glycerol matrix) on a JEOL SX 102 mass spectrometer.…”

Section: Generalmentioning

confidence: 99%

Acylated triterpene saponins from the roots of Securidaca longepedunculata

et al. 2010

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Section: Generalmentioning

confidence: 99%

Acylated triterpene saponins from the roots of Securidaca longepedunculata

et al. 2010

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“…1) have been previously reported in references [18][19][20][21][22] (see Supporting Information). Ursolic acid (6) was purchased from Sigma-Aldrich.…”

Section: Extraction Isolation and Characterizationmentioning

confidence: 83%

“…The harvest of P. arenaria and P. ruwenzoriensis from the Democratic Republic of Congo, Z. geslini from the Algerian Sahara, and A. caprinus from Monastir, Tunisia, is detailed in the references [18][19][20][21][22].…”

Section: Plant Materialsmentioning

confidence: 99%

“…1), were used for the first time to detect specific IgG and IgM antibodies in MS patientsʼ sera and NBD by ELISA: (4) from Polygala ruwenzor-iensis Chod. [20], and 3-O-β-D-xylopyranosyl-24-O-β-D-glucopyranosyl-20,25-epoxycycloartane-3β,6α,16β,24α-tetrol (5) from Astragalus caprinus Maire (Fabaceae) [21,22]. In parallel, we used the glycopeptide CSF114(Glc)-based ELISA to compare antibody titers.…”

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confidence: 99%

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Natural Triterpene Glycosides for Antibody Recognition

et al. 2016

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!Multiple sclerosis is an autoimmune disease that affects the central nervous system. The key role of the glycosylation in disease pathogenesis has been previously studied and the synthetic Nglucosylated peptide CSF114(Glc) proved its efficiency in autoantibody recognition in the sera of multiple sclerosis patients. Herein, pure natural triterpene glycosides containing different glycosyl moieties were isolated and tested in multiple sclerosis patientsʼ sera to better understand the role of glycosylation. They were selected taking into account the nature and complexity of their osidic part. Five triterpene glycosides were isolated from several plants with more than 95% purity. The interaction between these glycosides and autoantibodies was evaluated in an enzyme-linked immunosorbent assay measuring IgG and IgM levels in multiple sclerosis patients and healthy blood donors, and the results were compared with those of CSF114(Glc). For each antigen, Mann Whitney and receiver operating characteristic-based analysis were performed to evaluate any statistical significance of the results. The five natural triterpene glycosides showed good capacity to recognize IgMs (sensitivity up to 38 %) with a high specificity (88.9%) for multiple sclerosis patients.Key words multiple sclerosis · triterpene glycosides · autoimmune disease · biomarkers · autoantibody recognition Supporting information available online at http://www.thieme-connect.de/products Complex glycoconjugates, including glycolipids and glycoproteins, are commonly displayed on cell surfaces, where they play crucial roles as intermediaries in extracellular communication and signalling networks [1][2][3]. Therefore, studies on glycan modification patterns of glycoconjugates are a great challenge in medical diagnostic research, offering insight into cellular molecular mechanisms. Moreover, glycoconjugates can be proposed as molecular biomarkers for the disease activity [4,5]. In the field of autoimmunity, different approaches are used to investigate the structures and functions of complex naturally occurring glycoconjugates leading to the identification of autoantigens associated with different autoimmune diseases. In particular, in the context of multiple sclerosis (MS), the development of serum antibodies as biomarkers to be used for the diagnosis, monitoring, and prognosis of such a heterogeneous disease is a challenge because of the ambiguous identification of antigens (Ags) implicated in the disease. MS pathogenesis has not been yet elucidated but includes viral, immunological, and vascular hypotheses [6]. Most of the putative Ags belong to the myelin protein family (i.e., myelin basic protein, proteolipid lipoprotein, and myelin oligodendrocyte glycoprotein). Moreover, pathophysiological post-translational modifications of native Ags can trigger the immune system to generate autoantibodies escaping conventional diagnostic procedures [7]. Thus, autoantibodies against aberrant glycosylations have been hypothesized as diagnostic biomarkers in MS [8,9]. I...

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“…As the summarized results shown in Table 1, Table 2 and Table 3 and Figure 1, Figure 2, Figure 3 and Figure 4, 46 kinds of Astragalus species have been studied for their chemical constituents in recent years [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,…”

Section: Phytochemistrymentioning

confidence: 99%

A Review of Recent Research Progress on the Astragalus Genus

Li¹,

Qu²,

Dong³

et al. 2014

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Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) Bge. and its processed products are listed in the China Pharmacopeia for "qi deficiency" syndrome treatment. However, more and more researches on other species of Astragalus have been conducted recently. We summarize the recent researches of Astragalus species in phytochemistry and pharmacology. More than 200 constituents, including saponins and flavonoids, obtained from 46 species of Astragalus genus were collected for this article. In pharmacological studies, crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development. OPEN ACCESS

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A new oleanane glycoside from the roots of Astragalus caprinus

Cited by 16 publications

References 9 publications

Acylated triterpene saponins from the roots of Securidaca longepedunculata

Acylated triterpene saponins from the roots of Securidaca longepedunculata

Natural Triterpene Glycosides for Antibody Recognition

A Review of Recent Research Progress on the Astragalus Genus

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