A new nutraceutical resource from a rare native plant growing in Turkey and for its spectro-chemical and biological insights: Endemic Diplotaenia bingolensis (Apiaceae)

Geçibesler, İbrahim Halil; Erdoğan, Mehmet Kadir

doi:10.1016/j.saa.2019.117358

Cited by 10 publications

(2 citation statements)

References 48 publications

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“…Similarly, in this study, it was observed that P. oleracea methanol extract was exhibited a dosedependent effect on both cancer cell lines, but the antiproliferative activity was further increased especially at high concentrations. This difference may be due to the use of methanol, which has a different polarity, in extraction, and the different geography and climatic conditions where the plant samples were collected (Gecibesler and Erdogan, 2019). A previous study showed that the methanolic extract of P. oleracea was non-toxic in normal Chang liver cells and was safe for daily consumption (Payudara et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

The Chemosensitizing Effect of Portulaca oleracea Methanol Extract on Human Colorectal and Lung Cancer Cells Against Irinotecan

Erdoğan

2021

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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Cancer is a major health problem causing great damage in recent years worldwide. Serious side effects of chemotherapeutics used in cancer treatment make natural products valuable. Combined use of chemotherapy drugs and herbal products is an important approach in reducing side effects and revealing a more effective treatment. In this study, the effects of methanolic extract from Portulaca oleracea (POM) alone and in combination with irinotecan were investigated against human colorectal carcinoma cell line HCT116 and human lung adenocarcinoma cell line A549. The antiproliferative/anti-colony formation effects were determined using WST-1 assay and clonogenic assay. Cell death detection enzyme-linked immunosorbent assay (ELISA) was employed to exhibit the triggered apoptosis, and quantitative real time polimerase chain reaction (qRT-PCR) was performed to evaluate the mRNA expression of mTOR, Akt and PTEN genes, which are significant modulators of apoptotic and survival pathways. It was determined that 72 h treatment with increasing concentrations of POM (0-1000 µg mL -1 ) decreased the viability of HCT116 and A549 cells in a dose-dependent manner. Also, POM and irinotecan exhibited synergistic effects in both cell lines. The combination of POM and irinotecan suppressed the colony forming capacity of HCT116 and A549 cells by 84% and 79%, respectively. POM also altered mTOR, Akt and PTEN gene expressions in HCT116 and A549 carcinoma cells, both alone and in combination with irinotecan. This study indicates that the phytotherapeutic effect of P. oleracea needs to be studied more intensively.

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Section: Resultsmentioning

confidence: 99%

The Chemosensitizing Effect of Portulaca oleracea Methanol Extract on Human Colorectal and Lung Cancer Cells Against Irinotecan

Erdoğan

2021

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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“…Considering the lipophilic component variety of Bingöl propolis, it was quite remarkable that it was rich in unsaturated fatty acids such as oleic acid (omega 9), which provides significant benefits to human health in the daily diet, especially in EHI and EEI isolates. These unsaturated fatty acids, such as oleic acid, linoleic acid, and linolenic acid have been reported to show broadspectrum biological activity [35][36][37] . In addition, the many beneficial effects of α-amyrone and β-amyrin and sesquiterpenoids, which are dominant in EI isolate, have also been reported [38][39][40].…”

Section: Lipophilic Compoundsmentioning

confidence: 99%

Bingöl Propolis İzolatlarının Biyolojik Aktivitesinin, Lipofilik ve Uçucu Organik Bileşenlerinin Belierlenmesi

Uçar

Geçibesler

Sudağıdan

et al. 2020

Türk Doğa Ve Fen Dergisi

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In this study, the biological activity and chemical composition of Bingöl propolis were investigated. The isolates, including ethanol isolate (EI), hexane isolate (HI), and essential oil isolate (EOI), were prepared from raw propolis. The lipophilic and volatile organic compounds in isolates were analyzed by Gas Chromatography-Mass Spectrometry (GS-MS) measurements. Bingöl propolis isolates showed antimicrobial activity against reference pathogen bacterial strains, including Staphylococcus aureus (ATCC 25923), Bacillus cereus (NRRL-B-3711) Escherichia coli (ATCC 25922), Salmonella enterica subsp. enterica serovar Typhimurium (ATCC 14028), while B. cereus was observed to be the most susceptible bacteria to all tested propolis isolates. It was observed that EI showed the highest antimicrobial and antioxidant activity compared to other isolates. The presence of bioactive components in the lipophilic and essential oil isolates of Bingöl propolis may have contributed to the biological activity of propolis. Bingöl propolis isolates (EI and EOI) obtained in this study have the potential to be used as natural preservatives in food systems.

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Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE

Erdoğan

Geçibesler

Yapar

et al. 2021

Bioorganic Chemistry

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A new nutraceutical resource from a rare native plant growing in Turkey and for its spectro-chemical and biological insights: Endemic Diplotaenia bingolensis (Apiaceae)

Cited by 10 publications

References 48 publications

The Chemosensitizing Effect of Portulaca oleracea Methanol Extract on Human Colorectal and Lung Cancer Cells Against Irinotecan

The Chemosensitizing Effect of Portulaca oleracea Methanol Extract on Human Colorectal and Lung Cancer Cells Against Irinotecan

Bingöl Propolis İzolatlarının Biyolojik Aktivitesinin, Lipofilik ve Uçucu Organik Bileşenlerinin Belierlenmesi

Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE

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